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Journal of Clinical Pathways

From the Journal

Original Research
12/15/2025
Gagandeep Kaur, DO; Havi Rosen, MD; Luke Shenton, MD; Terrence Sun, DO; Abigail Mackenzie, MD; Leah Puglisi, MS; Catherine Weir, DO; Marin Feldman Xavier, MD; Diana Vesselinovitch Maslov, MD
This retrospective study of patients treated with immune checkpoint inhibitors highlights cancer-specific patterns of end-of-life use, the risks and timing of immune-related adverse events, and the critical need for patient-centered...
This retrospective study of patients treated with immune checkpoint inhibitors highlights cancer-specific patterns of end-of-life use, the risks and timing of immune-related adverse events, and the critical need for patient-centered...
This retrospective study of...
12/15/2025
Journal of Clinical Pathways
Original Research
12/15/2025
Lisa Raff, PharmD; Rozanne Wilson, PhD; Richard Murphy, BA; Amal Jamaleddine, BA; Nicole Bariahtaris, BA; Meaghan Roach, MPH
A community-derived playbook from OneOncology outlines practical strategies for delivering teclistamab step-up dosing in outpatient settings, enabling safer, more convenient access for patients.
A community-derived playbook from OneOncology outlines practical strategies for delivering teclistamab step-up dosing in outpatient settings, enabling safer, more convenient access for patients.
A community-derived playbook...
12/15/2025
Journal of Clinical Pathways
Original Research
10/15/2025
Mehmet Asim Bilen, MD; Aleksandar Zafirovski, MBA; Robert A. Bailey, MD; Ibrahim Khilfeh, PharmD; Urmi Bapat, MD; Kyra Svoboda, BS; Michael Kramer, MD, MBA
This study presents the development of an evidence-informed care pathway and EHR-integrated tools to standardize tumor and germline testing workflows for patients with metastatic prostate cancer.
This study presents the development of an evidence-informed care pathway and EHR-integrated tools to standardize tumor and germline testing workflows for patients with metastatic prostate cancer.
This study presents the...
10/15/2025
Journal of Clinical Pathways
Original Research
10/15/2025
Jennifer Wheeley, MS, FNP-C; Nikita Chintapally, MD; Kanchan Kulkarni, MD; Gabriel Yohe, MS; Priya Kundra, MD; Jennifer Rosen, MD; Muhammad M. Shaikh, MD; Meeta Sharma, MD; Jason Wexler, MD; Kenneth D. Burman, MD; Leila Shobab, MD; Irina Veytsman, MD
In this study, targeted redifferentiation with BRAF and MEK inhibition restored radioactive iodine avidity in the majority of patients with refractory differentiated thyroid cancer, highlighting a promising therapeutic approach.
In this study, targeted redifferentiation with BRAF and MEK inhibition restored radioactive iodine avidity in the majority of patients with refractory differentiated thyroid cancer, highlighting a promising therapeutic approach.
In this study, targeted...
10/15/2025
Journal of Clinical Pathways
From the Field
08/15/2025
Anna Bolha, MPAS, PA; Rebecca Maniago, PharmD, BCOP; Nina Sardesh; Taylor Dias-Foundas; James Roose, MA; Colin Harvey; Marcello Ricottone; Eric Weber; Susan Sabo-Wagner, MSN, RN, OCN, NEA-BC; Brian Patrick Mulherin, MD; Andrew Hertler, MD, FACP; James Hamrick, MD, MPH
In this report, researchers discuss a real-world study of treatment selection patterns across American Oncology Network medical oncologists, which analyzed pathway adherence rates before and after a pilot project where Evolent level 1...
In this report, researchers discuss a real-world study of treatment selection patterns across American Oncology Network medical oncologists, which analyzed pathway adherence rates before and after a pilot project where Evolent level 1...
In this report, researchers...
08/15/2025
Journal of Clinical Pathways
From the Field
08/15/2025
Samyukta Mullangi, MD, MBA; Alphan Kirayoglu, MA; Amila Patel, PharmD; Robert J. Green, MD, MSCE; Keshav Goel, MS; James Gilmore, PharmD; Stephen Garrel Divers, MD
To curb the high cost of cancer care driven by flat-dose pricing of drugs like pembrolizumab, the American Oncology Network has implemented a suite of technological and workflow innovations that increased weight-based dosing, offering a...
To curb the high cost of cancer care driven by flat-dose pricing of drugs like pembrolizumab, the American Oncology Network has implemented a suite of technological and workflow innovations that increased weight-based dosing, offering a...
To curb the high cost of cancer...
08/15/2025
Journal of Clinical Pathways
Original Research
06/16/2025
John P. Geisler, MD, PharmD, MS; Nagadharshan Devendra, MD; Kelly J. Manahan, MD, MBA
This study evaluates how indication-specific pricing for bevacizumab in cervical and colon cancer could align with a $100 000 per quality adjusted life-year willingness-to-pay threshold.
This study evaluates how indication-specific pricing for bevacizumab in cervical and colon cancer could align with a $100 000 per quality adjusted life-year willingness-to-pay threshold.
This study evaluates how...
06/16/2025
Journal of Clinical Pathways
From the Field
04/15/2025
Sang Chau, PharmD, BCOP; Amy VanGalder, PharmD, BCOP; Garrick Wong, PharmD; Terra Wonsettler, PharmD, MBA; Emma Domico, MS; Andrew Hertler, MD, FACP
This study discusses how Evolent is tackling the rising costs of cancer treatment by actively reducing low-value oncology care through strategic interventions.
This study discusses how Evolent is tackling the rising costs of cancer treatment by actively reducing low-value oncology care through strategic interventions.
This study discusses how Evolent...
04/15/2025
Journal of Clinical Pathways
Perspectives
12/02/2024
Maggie Dietrick, MPH; Palak Patel, MHA; Tom Valuck, MD, JD
This article explores the use of artificial intelligence (AI) in health care quality measurement and tactics to mitigate bias in AI-enhanced measurement.
This article explores the use of artificial intelligence (AI) in health care quality measurement and tactics to mitigate bias in AI-enhanced measurement.
This article explores the use of...
12/02/2024
Journal of Clinical Pathways
From the Field
12/02/2024
Daniel Simmons, PharmD, MS; Rebecca Stone, MD; James Ryan, MSc; Jigna Bhalla, PharmD; Kimmie McLaurin, MS
This study models the clinical outcomes and costs associated with utilizing an HRD biomarker-guided (BMG) approach to first-line AOC maintenance compared with a non-biomarker-guided (NBMG) approach.
This study models the clinical outcomes and costs associated with utilizing an HRD biomarker-guided (BMG) approach to first-line AOC maintenance compared with a non-biomarker-guided (NBMG) approach.
This study models the clinical...
12/02/2024
Journal of Clinical Pathways

KOL Insights

Houda Hachad, PharmD
Videos
12/04/2025
Houda Hachad, PharmD
Houda Hachad, PharmD, discusses how emerging US Food and Drug Administration (FDA) actions and expanding pharmacogenomic insights may soon transform fluoropyrimidine safety and reshape precision oncology from diagnosis through survivorship.
Houda Hachad, PharmD, discusses how emerging US Food and Drug Administration (FDA) actions and expanding pharmacogenomic insights may soon transform fluoropyrimidine safety and reshape precision oncology from diagnosis through survivorship.
Houda Hachad, PharmD, discusses...
12/04/2025
Journal of Clinical Pathways
Houda Hachad, PharmD
Videos
12/04/2025
Houda Hachad, PharmD
Learn why mandatory DPYD testing may be just the beginning of a broader shift toward pharmacogenomics-driven safety in cancer treatment.
Learn why mandatory DPYD testing may be just the beginning of a broader shift toward pharmacogenomics-driven safety in cancer treatment.
Learn why mandatory DPYD testing...
12/04/2025
Journal of Clinical Pathways
BDHC thumbnail
Videos
11/26/2025
John Hennessy, MBA; Michael Kolodziej, MD
In this episode of Breaking Down Health Care, John Hennessy and Dr. Michael Kolodziej explore the crucial difference between cancer screening and true cancer prevention, highlighting how lifestyle changes, vaccines, and emerging therapies...
In this episode of Breaking Down Health Care, John Hennessy and Dr. Michael Kolodziej explore the crucial difference between cancer screening and true cancer prevention, highlighting how lifestyle changes, vaccines, and emerging therapies...
In this episode of Breaking Down...
11/26/2025
Cancer Care Business Exchange
Koulopoulos
Videos
10/31/2025
Thomas Koulopoulos
Futurist Thomas Koulopoulos explores how “gigatrends”—seismic global shifts like changing demographics and AI—are redefining health care, urging a balance between innovation and trust as the industry evolves toward more human-centered,...
Futurist Thomas Koulopoulos explores how “gigatrends”—seismic global shifts like changing demographics and AI—are redefining health care, urging a balance between innovation and trust as the industry evolves toward more human-centered,...
Futurist Thomas Koulopoulos...
10/31/2025
Journal of Clinical Pathways
CONFERENCE COVERAGE
10/22/2025
Lavi Kwiatkowsky
At CPC+CBEx 2025, Lavi Kwiatkowsky discussed how payer frameworks, accreditation requirements, and operational challenges are shaping access to CAR T-cell and bispecific therapies in community oncology—and how technology could bridge the gap...
At CPC+CBEx 2025, Lavi Kwiatkowsky discussed how payer frameworks, accreditation requirements, and operational challenges are shaping access to CAR T-cell and bispecific therapies in community oncology—and how technology could bridge the gap...
At CPC+CBEx 2025, Lavi...
10/22/2025
Journal of Clinical Pathways
BDHC thumbnail
Videos
10/15/2025
John Hennessy, MBA; Michael Kolodziej, MD
In this episode of Breaking Down Health Care, John Hennessy and Dr Michael Kolodziej explore the evolving landscape of cancer screening—from the advances in imaging and artificial intelligence to the promise and pitfalls of new DNA- and...
In this episode of Breaking Down Health Care, John Hennessy and Dr Michael Kolodziej explore the evolving landscape of cancer screening—from the advances in imaging and artificial intelligence to the promise and pitfalls of new DNA- and...
In this episode of Breaking Down...
10/15/2025
Cancer Care Business Exchange
Kuntz
Conference Coverage
10/10/2025
Gordon Kuntz
The Predictable Cost of Care (PCC) Working Group is expanding its economic models to include patient-centric metrics by developing a parallel track that measures patient time, healthcare interactions, and variability in coverage, aiming to...
The Predictable Cost of Care (PCC) Working Group is expanding its economic models to include patient-centric metrics by developing a parallel track that measures patient time, healthcare interactions, and variability in coverage, aiming to...
The Predictable Cost of Care...
10/10/2025
Journal of Clinical Pathways
Tremonti Headshot
Videos
10/08/2025
Carole Tremonti, RN, MBA
From expanding stakeholder collaboration to tackling data transparency and real-world model testing, the Predictable Cost of Care initiative is transforming how clinical pathways are developed and decisions are driven by data.
From expanding stakeholder collaboration to tackling data transparency and real-world model testing, the Predictable Cost of Care initiative is transforming how clinical pathways are developed and decisions are driven by data.
From expanding stakeholder...
10/08/2025
Journal of Clinical Pathways
Videos
10/02/2025
Lalan Wilfong, MD; Aimee Ginsburg, PharmD, BCPS
In this CPC+CBEx 2025 interview, experts Lalan Wilfong, MD, and Aimee Ginsburg Chesnick, PharmD, BCPS, explore how real-world evidence is shaping drug approvals, clinical decision-making, and future opportunities for stronger, more actionable...
In this CPC+CBEx 2025 interview, experts Lalan Wilfong, MD, and Aimee Ginsburg Chesnick, PharmD, BCPS, explore how real-world evidence is shaping drug approvals, clinical decision-making, and future opportunities for stronger, more actionable...
In this CPC+CBEx 2025 interview,...
10/02/2025
Journal of Clinical Pathways
BDHC thumbnail
Videos
09/16/2025
John Hennessy, MBA; Michael Kolodziej, MD
In this episode of Breaking Down Health Care, John Hennessy and Dr Michael Kolodziej explore the many dimensions of second opinions in oncology—ranging from in-practice consultations to academic referrals, payer-sponsored programs, and...
In this episode of Breaking Down Health Care, John Hennessy and Dr Michael Kolodziej explore the many dimensions of second opinions in oncology—ranging from in-practice consultations to academic referrals, payer-sponsored programs, and...
In this episode of Breaking Down...
09/16/2025
Cancer Care Business Exchange

In the News

Clinical Pathways NEXT, Free Webinar, CPC, Oncology Pathways
Press Release
02/03/2026
As oncology innovation accelerates and evidence evolves faster than traditional pathway update cycles, stakeholders need clearer insight into how clinical pathways adapt in real time. Clinical Pathways NEXT, a new, free quarterly virtual...
As oncology innovation accelerates and evidence evolves faster than traditional pathway update cycles, stakeholders need clearer insight into how clinical pathways adapt in real time. Clinical Pathways NEXT, a new, free quarterly virtual...
As oncology innovation...
02/03/2026
Journal of Clinical Pathways
News
01/23/2026
Hannah Musick
A comprehensive review highlights emerging adoptive cell therapy strategies aimed at overcoming immune suppression, antigen heterogeneity, and safety challenges in ovarian cancer.
A comprehensive review highlights emerging adoptive cell therapy strategies aimed at overcoming immune suppression, antigen heterogeneity, and safety challenges in ovarian cancer.
A comprehensive review...
01/23/2026
Journal of Clinical Pathways
News
01/22/2026
Lisa Kuhns, PhD, MD
Medicare Advantage (MA) enrollees with colorectal cancer (CRC) and advanced non–small cell lung cancer (NSCLC) were less likely than traditional Medicare (TM) beneficiaries to receive cancer-directed drugs and, when treated, were less likely...
Medicare Advantage (MA) enrollees with colorectal cancer (CRC) and advanced non–small cell lung cancer (NSCLC) were less likely than traditional Medicare (TM) beneficiaries to receive cancer-directed drugs and, when treated, were less likely...
Medicare Advantage (MA)...
01/22/2026
Journal of Clinical Pathways
News
01/19/2026
Grace Taylor, MS, MA
A national Medicare study found that patients enrolled in Medicare Advantage were significantly less likely than those in traditional Medicare to receive major cancer surgery at high-quality hospitals, highlighting potential network-related...
A national Medicare study found that patients enrolled in Medicare Advantage were significantly less likely than those in traditional Medicare to receive major cancer surgery at high-quality hospitals, highlighting potential network-related...
A national Medicare study found...
01/19/2026
Journal of Clinical Pathways
News
01/14/2026
Grace Taylor, MS, MA
McKesson’s Advancing Community Oncology Report 2025 reveals how community oncology practices across the US are navigating rapid advances in precision medicine, clinical trials, and technology as they care for the majority of cancer patients.
McKesson’s Advancing Community Oncology Report 2025 reveals how community oncology practices across the US are navigating rapid advances in precision medicine, clinical trials, and technology as they care for the majority of cancer patients.
McKesson’s Advancing Community...
01/14/2026
Journal of Clinical Pathways
News
01/12/2026
Hannah Musick
The American Cancer Society’s 2025 report reveals that education level and rural residence drive larger US cancer mortality disparities than race alone, underscoring the central role of socioeconomic and geographic inequities across the...
The American Cancer Society’s 2025 report reveals that education level and rural residence drive larger US cancer mortality disparities than race alone, underscoring the central role of socioeconomic and geographic inequities across the...
The American Cancer Society’s...
01/12/2026
Journal of Clinical Pathways
News
01/08/2026
Grace Taylor, MS, MA
Real-world data from 6 US cancer centers show no significant survival differences between atezolizumab/bevacizumab and durvalumab/tremelimumab as first-line therapy for unresectable hepatocellular carcinoma (uHCC), with liver function...
Real-world data from 6 US cancer centers show no significant survival differences between atezolizumab/bevacizumab and durvalumab/tremelimumab as first-line therapy for unresectable hepatocellular carcinoma (uHCC), with liver function...
Real-world data from 6 US cancer...
01/08/2026
Journal of Clinical Pathways
News
01/07/2026
Grace Taylor, MS, MA
Nearly half of patients referred for chimeric antigen receptor T-cell (CAR T) therapy at a major academic cancer center never received treatment, with disease progression, limited product availability, and potential racial disparities...
Nearly half of patients referred for chimeric antigen receptor T-cell (CAR T) therapy at a major academic cancer center never received treatment, with disease progression, limited product availability, and potential racial disparities...
Nearly half of patients referred...
01/07/2026
Journal of Clinical Pathways
News
12/19/2025
Grace Taylor, MS, MA
Pre-apheresis lenalidomide significantly improved T-cell fitness and pharmacodynamic activity of idecabtagene vicleucel (ide-cel) in newly diagnosed multiple myeloma (NDMM), according to a KarMMa-2 cross-cohort analysis.
Pre-apheresis lenalidomide significantly improved T-cell fitness and pharmacodynamic activity of idecabtagene vicleucel (ide-cel) in newly diagnosed multiple myeloma (NDMM), according to a KarMMa-2 cross-cohort analysis.
Pre-apheresis lenalidomide...
12/19/2025
Journal of Clinical Pathways
News
12/12/2025
Lisa Kuhns, PhD, MD
Structural racism, rather than biological differences or treatment patterns, appears to drive survival disparities in myelofibrosis (MF) among minority patients, according to a new multicenter analysis, according to study results published in...
Structural racism, rather than biological differences or treatment patterns, appears to drive survival disparities in myelofibrosis (MF) among minority patients, according to a new multicenter analysis, according to study results published in...
Structural racism, rather than...
12/12/2025
Journal of Clinical Pathways

Quality Outlook

Blog
08/27/2025
The 2025 Clinical Pathways Congress + Cancer Care Business Exchange (CPC+CBEx), to be held September 5-6 in Boston, will confront these challenges head-on through 13 powerful abstracts that demonstrate what it takes to translate evidence into...
The 2025 Clinical Pathways Congress + Cancer Care Business Exchange (CPC+CBEx), to be held September 5-6 in Boston, will confront these challenges head-on through 13 powerful abstracts that demonstrate what it takes to translate evidence into...
The 2025 Clinical Pathways...
08/27/2025
Journal of Clinical Pathways
Quality Outlook
03/05/2025
Bridget Doherty, MPH, MS; Silas Martin, MS; Tom Valuck, MD, JD
Johnson & Johnson’s research highlights the significant impact of the FDA’s Accelerated Approval Program, estimating that earlier access to cancer therapies has provided approximately 263 000 additional life years to patients, reinforcing the...
Johnson & Johnson’s research highlights the significant impact of the FDA’s Accelerated Approval Program, estimating that earlier access to cancer therapies has provided approximately 263 000 additional life years to patients, reinforcing the...
Johnson & Johnson’s research...
03/05/2025
Journal of Clinical Pathways
CPC + CBEx: Breaking down barriers and pushing boundaries of cancer care
Blog
08/07/2024
Winston Wong, PharmD
At CPC+CBEx, we bring together stakeholders invested throughout the entire patient journey.
At CPC+CBEx, we bring together stakeholders invested throughout the entire patient journey.
At CPC+CBEx, we bring together...
08/07/2024
Journal of Clinical Pathways
Editor in chief Winston Wong, PharmD.
Editor Insights
02/13/2024
Winston Wong, PharmD
Throughout 2023, feature articles in the Journal of Clinical Pathways offered valuable insights into the most important and compelling topics in oncology and other disease areas. This blog collects the top 5 most-read articles of the year.
Throughout 2023, feature articles in the Journal of Clinical Pathways offered valuable insights into the most important and compelling topics in oncology and other disease areas. This blog collects the top 5 most-read articles of the year.
Throughout 2023, feature...
02/13/2024
Journal of Clinical Pathways
Kendall Logan, MPH.
Quality Outlook
02/12/2024
Anne DiSalvo, MPH, MBA; Kendall Logan, MPH; Erik Muther; Tom Valuck, MD, JD
This blog post is the last in a three-part series exploring the disparities related to human papilloma virus (HPV) vaccination rates in the US.
This blog post is the last in a three-part series exploring the disparities related to human papilloma virus (HPV) vaccination rates in the US.
This blog post is the last in a...
02/12/2024
Journal of Clinical Pathways
Theresa Schmidt headshot.
Quality Outlook
02/02/2024
Tom Valuck, MD, JD; Erik Muther; Theresa Schmidt, MA, PMP, CSPO; Danny Bellet, MBA; Donna Dugan, PhD, MS; David Sloan, PhD
This past fall, leaders from the Real Chemistry Market Access team attended key quality-related events to understand trends and learn from other quality and value experts.
This past fall, leaders from the Real Chemistry Market Access team attended key quality-related events to understand trends and learn from other quality and value experts.
This past fall, leaders from the...
02/02/2024
Journal of Clinical Pathways
Anne Disalvo headshot
Quality Outlook
11/10/2023
Tom Valuck, MD, JD; Anne DiSalvo, MPH, MBA; Kendall Logan, MPH; Erik Muther
This is the second part of a 3-part blog series that explores issues related to HPV vaccination rates in the US. In this blog, the racial and ethnic disparities in HPV vaccination are explored.
This is the second part of a 3-part blog series that explores issues related to HPV vaccination rates in the US. In this blog, the racial and ethnic disparities in HPV vaccination are explored.
This is the second part of a...
11/10/2023
Journal of Clinical Pathways
Anne DiSalvo.
Quality Outlook
10/03/2023
Tom Valuck, MD, JD; Anne DiSalvo, MPH, MBA; Kendall Logan, MPH; Erik Muther
This is the first of a 3-part blog series that explores issues related to HPV vaccination rates in the US. In this blog, vaccination disparities are explored among the highest and lowest performing states.
This is the first of a 3-part blog series that explores issues related to HPV vaccination rates in the US. In this blog, vaccination disparities are explored among the highest and lowest performing states.
This is the first of a 3-part...
10/03/2023
Journal of Clinical Pathways
David Blaisdell, BA, Real Chemistry.
Quality Outlook
09/22/2023
David Blaisdell, BA; Tom Valuck, MD, JD
We previously wrote about lessons from the Oncology Care Model (OCM) that the Center for Medicare and Medicaid Innovation (CMMI) could apply to the Enhancing Oncology Model (EOM). Subsequently, CMMI recently released an evaluation report for...
We previously wrote about lessons from the Oncology Care Model (OCM) that the Center for Medicare and Medicaid Innovation (CMMI) could apply to the Enhancing Oncology Model (EOM). Subsequently, CMMI recently released an evaluation report for...
We previously wrote about...
09/22/2023
Journal of Clinical Pathways
Jacqlyn Riposo
Quality Outlook
06/08/2023
Tom Valuck, MD, JD; Jacqlyn Riposo, MBA
This blog discusses the Centers for Medicare and Medicaid Services new cell and Gene Therapy Access Model proposal and recommends different ways the Center for Medicare and Medicaid Innovation can apply quality measurement to cell and gene...
This blog discusses the Centers for Medicare and Medicaid Services new cell and Gene Therapy Access Model proposal and recommends different ways the Center for Medicare and Medicaid Innovation can apply quality measurement to cell and gene...
This blog discusses the Centers...
06/08/2023
Journal of Clinical Pathways