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11/18/2025
Thomas Hope, MD; Amir Iravani, MD, FRACP; Daneng Li, MD; Jonathan Strosberg, MD
Experts reflect on evolving roles of alpha and beta emitters, novel isotopes in development, and the balance between efficacy and toxicity that will define next-generation radioligand therapy.
Experts reflect on evolving roles of alpha and beta emitters, novel isotopes in development, and the balance between efficacy and toxicity that will define next-generation radioligand therapy.
Experts reflect on evolving...
11/18/2025
Radiopharmaceutical Education Institute
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Videos
11/18/2025
Thomas Hope, MD; Amir Iravani, MD, FRACP; Daneng Li, MD; Jonathan Strosberg, MD
Experts analyze early and long-term data from ALPHAMEDIX-02 and other alpha-emitter trials, including efficacy, toxicity patterns, and key differences between actinium- and lead-based compounds.
Experts analyze early and long-term data from ALPHAMEDIX-02 and other alpha-emitter trials, including efficacy, toxicity patterns, and key differences between actinium- and lead-based compounds.
Experts analyze early and...
11/18/2025
Radiopharmaceutical Education Institute
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Videos
11/18/2025
Thomas Hope, MD; Amir Iravani, MD, FRACP; Daneng Li, MD; Jonathan Strosberg, MD
The panel examines tumor receptor expression, use of molecular imaging, and ongoing studies exploring alpha-emitting radioligand therapies and sequencing strategies in advanced NETs.
The panel examines tumor receptor expression, use of molecular imaging, and ongoing studies exploring alpha-emitting radioligand therapies and sequencing strategies in advanced NETs.
The panel examines tumor...
11/18/2025
Radiopharmaceutical Education Institute
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Videos
11/18/2025
Thomas Hope, MD; Amir Iravani, MD, FRACP; Daneng Li, MD; Jonathan Strosberg, MD
Experts discuss data from pivotal trials that evaluated progression-free survival outcomes, treatment sequencing, and considerations for first-line PRRT use.
Experts discuss data from pivotal trials that evaluated progression-free survival outcomes, treatment sequencing, and considerations for first-line PRRT use.
Experts discuss data from...
11/18/2025
Radiopharmaceutical Education Institute
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Videos
11/18/2025
Thomas Hope, MD; Amir Iravani, MD, FRACP; Daneng Li, MD; Jonathan Strosberg, MD
Experts review the evolving treatment landscape for neuroendocrine tumors (NETs), highlighting approved systemic and liver-directed therapies and ongoing challenges in treatment sequencing.
Experts review the evolving treatment landscape for neuroendocrine tumors (NETs), highlighting approved systemic and liver-directed therapies and ongoing challenges in treatment sequencing.
Experts review the evolving...
11/18/2025
Radiopharmaceutical Education Institute
News
10/28/2025
Janelle Bradley
¹⁷⁷Lu-edotreotide significantly improved progression-free survival and objective response rates compared to everolimus in patients with advanced GEP-NETs, with consistent benefits across tumor grades, sites, and prior treatment settings,...
¹⁷⁷Lu-edotreotide significantly improved progression-free survival and objective response rates compared to everolimus in patients with advanced GEP-NETs, with consistent benefits across tumor grades, sites, and prior treatment settings,...
¹⁷⁷Lu-edotreotide significantly...
10/28/2025
Radiopharmaceutical Education Institute
News
10/28/2025
Janelle Bradley
Obrixtamig, a DLL3/CD3 bispecific T-cell engager, demonstrated a 40% objective response rate and durable, manageable activity in patients with DLL3-high extrapulmonary neuroendocrine carcinoma, according to a phase 1 trial.
Obrixtamig, a DLL3/CD3 bispecific T-cell engager, demonstrated a 40% objective response rate and durable, manageable activity in patients with DLL3-high extrapulmonary neuroendocrine carcinoma, according to a phase 1 trial.
Obrixtamig, a DLL3/CD3...
10/28/2025
Oncology
News
10/28/2025
Janelle Bradley
Findings from an international randomized trial show transarterial embolization (TAE) and conventional chemoembolization (cTACE) demonstrated comparable efficacy for liver-dominant neuroendocrine tumor metastases, though TAE was associated...
Findings from an international randomized trial show transarterial embolization (TAE) and conventional chemoembolization (cTACE) demonstrated comparable efficacy for liver-dominant neuroendocrine tumor metastases, though TAE was associated...
Findings from an international...
10/28/2025
Oncology
News
10/28/2025
Janelle Bradley
In the phase 2 ALPHAMEDIX 02 trial, 212Pb-DOTAMTATE achieved a 30.8% objective response rate and a 96% disease control rate with a manageable safety profile in patients with advanced SSTR-positive GEP-NETs who had progressed following prior...
In the phase 2 ALPHAMEDIX 02 trial, 212Pb-DOTAMTATE achieved a 30.8% objective response rate and a 96% disease control rate with a manageable safety profile in patients with advanced SSTR-positive GEP-NETs who had progressed following prior...
In the phase 2 ALPHAMEDIX 02...
10/28/2025
Radiopharmaceutical Education Institute
News
10/28/2025
Janelle Bradley
In the phase 2 ALPHAMEDIX 02 trial, 212Pb-DOTAMTATE produced a 57% objective response rate and durable disease control with a favorable safety profile in PRRT-naïve patients with advanced somatostatin receptor-positive GEP-NETs.
In the phase 2 ALPHAMEDIX 02 trial, 212Pb-DOTAMTATE produced a 57% objective response rate and durable disease control with a favorable safety profile in PRRT-naïve patients with advanced somatostatin receptor-positive GEP-NETs.
In the phase 2 ALPHAMEDIX 02...
10/28/2025
Radiopharmaceutical Education Institute