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Gastrointestinal Cancer Specialty Channel

Gastrointestinal Cancer
Specialty Channel
News
01/21/2026
Stephanie Holland
Results from a multicenter, phase 3 trial demonstrated that anbenitamab plus chemotherapy improved survival compared with placebo plus chemotherapy among previously treated patients with HER2-positive gastric or gastroesophageal junction...
Results from a multicenter, phase 3 trial demonstrated that anbenitamab plus chemotherapy improved survival compared with placebo plus chemotherapy among previously treated patients with HER2-positive gastric or gastroesophageal junction...
Results from a multicenter,...
01/21/2026
Oncology
Conference Coverage
01/13/2026
Stephanie Holland
Phase 2b results from the TERRIFIC study demonstrate that neoadjuvant tislelizumab plus chemoradiotherapy shows clinical promise for locally advanced gastric or gastroesophageal junction cancer.
Phase 2b results from the TERRIFIC study demonstrate that neoadjuvant tislelizumab plus chemoradiotherapy shows clinical promise for locally advanced gastric or gastroesophageal junction cancer.
Phase 2b results from the...
01/13/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
Zolbetuximab plus mFLOFOX and nivolumab demonstrated clinical promise among HER2-negative patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma with high CLDN18.2 expression, according...
Zolbetuximab plus mFLOFOX and nivolumab demonstrated clinical promise among HER2-negative patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma with high CLDN18.2 expression, according...
Zolbetuximab plus mFLOFOX and...
01/08/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
According to results from the phase 3 HERIZON-GEA-01 trial, zanidatamab-based treatment demonstrates a promising survival benefit among previously untreated patients with HER2-positive metastatic gastroesophageal adenocarcinoma.
According to results from the phase 3 HERIZON-GEA-01 trial, zanidatamab-based treatment demonstrates a promising survival benefit among previously untreated patients with HER2-positive metastatic gastroesophageal adenocarcinoma.
According to results from the...
01/08/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
According to results from a multicenter phase 2 trial, first-line capecitabine plus carboplatin improved outcomes among previously untreated patients with metastatic or unresectable HER2-negative esophagogastric adenocarcinoma.
According to results from a multicenter phase 2 trial, first-line capecitabine plus carboplatin improved outcomes among previously untreated patients with metastatic or unresectable HER2-negative esophagogastric adenocarcinoma.
According to results from a...
01/08/2026
Oncology
News
10/20/2025
Stephanie Holland
Results from the phase 3 FORTITUDE-101 trial show adding bemarituzumab to mFOLFOX6 significantly improved survival among patients with unresectable, locally advanced or metastatic FGFR2b expressing gastric or gastroesophageal junction (GEJ)...
Results from the phase 3 FORTITUDE-101 trial show adding bemarituzumab to mFOLFOX6 significantly improved survival among patients with unresectable, locally advanced or metastatic FGFR2b expressing gastric or gastroesophageal junction (GEJ)...
Results from the phase 3...
10/20/2025
Oncology
News
10/17/2025
Stephanie Holland
Second interim analysis results from the phase 3 LEAP-014 trial found that the addition of lenvatinib to pembrolizumab plus chemotherapy did not significantly improve survival among patients with previously untreated metastatic esophageal...
Second interim analysis results from the phase 3 LEAP-014 trial found that the addition of lenvatinib to pembrolizumab plus chemotherapy did not significantly improve survival among patients with previously untreated metastatic esophageal...
Second interim analysis results...
10/17/2025
Oncology
News
10/17/2025
Janelle Bradley
Anbenitamab plus chemotherapy significantly improved OS and PFS, with a threefold higher response rate vs chemotherapy alone, in patients with previously treated HER2-positive gastric or GEJ cancer.
Anbenitamab plus chemotherapy significantly improved OS and PFS, with a threefold higher response rate vs chemotherapy alone, in patients with previously treated HER2-positive gastric or GEJ cancer.
Anbenitamab plus chemotherapy...
10/17/2025
Oncology
News
10/17/2025
Janelle Bradley
The phase 3 MATTERHORN trial showed that adding durvalumab to perioperative FLOT significantly improved OS and EFS vs FLOT alone in resectable gastric and GEJ adenocarcinoma, with benefits observed regardless of PD-L1 status.
The phase 3 MATTERHORN trial showed that adding durvalumab to perioperative FLOT significantly improved OS and EFS vs FLOT alone in resectable gastric and GEJ adenocarcinoma, with benefits observed regardless of PD-L1 status.
The phase 3 MATTERHORN trial...
10/17/2025
Oncology
News
08/01/2025
Stephanie Holland
According to results from the phase 3 DESTINY-Gastric04 trial, trastuzumab deruxtecan in the second line significantly improved outcomes compared to ramucirumab plus paclitaxel among patients with HER2-positive unresectable or metastatic...
According to results from the phase 3 DESTINY-Gastric04 trial, trastuzumab deruxtecan in the second line significantly improved outcomes compared to ramucirumab plus paclitaxel among patients with HER2-positive unresectable or metastatic...
According to results from the...
08/01/2025
Oncology
Conference Coverage
07/03/2025
Allison Casey
According to the MATTERHORN study, durvalumab plus FLOT chemotherapy demonstrated a statistically significant improvement of event-free survival for patients with resectable gastric/gastroesophageal junction adenocarcinoma, compared with...
According to the MATTERHORN study, durvalumab plus FLOT chemotherapy demonstrated a statistically significant improvement of event-free survival for patients with resectable gastric/gastroesophageal junction adenocarcinoma, compared with...
According to the MATTERHORN...
07/03/2025
Oncology

News

News
01/21/2026
Stephanie Holland
Results from a multicenter, phase 3 trial demonstrated that anbenitamab plus chemotherapy improved survival compared with placebo plus chemotherapy among previously treated patients with HER2-positive gastric or gastroesophageal junction...
Results from a multicenter, phase 3 trial demonstrated that anbenitamab plus chemotherapy improved survival compared with placebo plus chemotherapy among previously treated patients with HER2-positive gastric or gastroesophageal junction...
Results from a multicenter,...
01/21/2026
Oncology
Conference Coverage
01/13/2026
Stephanie Holland
Phase 2b results from the TERRIFIC study demonstrate that neoadjuvant tislelizumab plus chemoradiotherapy shows clinical promise for locally advanced gastric or gastroesophageal junction cancer.
Phase 2b results from the TERRIFIC study demonstrate that neoadjuvant tislelizumab plus chemoradiotherapy shows clinical promise for locally advanced gastric or gastroesophageal junction cancer.
Phase 2b results from the...
01/13/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
Zolbetuximab plus mFLOFOX and nivolumab demonstrated clinical promise among HER2-negative patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma with high CLDN18.2 expression, according...
Zolbetuximab plus mFLOFOX and nivolumab demonstrated clinical promise among HER2-negative patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma with high CLDN18.2 expression, according...
Zolbetuximab plus mFLOFOX and...
01/08/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
According to results from the phase 3 HERIZON-GEA-01 trial, zanidatamab-based treatment demonstrates a promising survival benefit among previously untreated patients with HER2-positive metastatic gastroesophageal adenocarcinoma.
According to results from the phase 3 HERIZON-GEA-01 trial, zanidatamab-based treatment demonstrates a promising survival benefit among previously untreated patients with HER2-positive metastatic gastroesophageal adenocarcinoma.
According to results from the...
01/08/2026
Oncology
Conference Coverage
01/08/2026
Stephanie Holland
According to results from a multicenter phase 2 trial, first-line capecitabine plus carboplatin improved outcomes among previously untreated patients with metastatic or unresectable HER2-negative esophagogastric adenocarcinoma.
According to results from a multicenter phase 2 trial, first-line capecitabine plus carboplatin improved outcomes among previously untreated patients with metastatic or unresectable HER2-negative esophagogastric adenocarcinoma.
According to results from a...
01/08/2026
Oncology
News
10/20/2025
Stephanie Holland
Results from the phase 3 FORTITUDE-101 trial show adding bemarituzumab to mFOLFOX6 significantly improved survival among patients with unresectable, locally advanced or metastatic FGFR2b expressing gastric or gastroesophageal junction (GEJ)...
Results from the phase 3 FORTITUDE-101 trial show adding bemarituzumab to mFOLFOX6 significantly improved survival among patients with unresectable, locally advanced or metastatic FGFR2b expressing gastric or gastroesophageal junction (GEJ)...
Results from the phase 3...
10/20/2025
Oncology
News
10/17/2025
Stephanie Holland
Second interim analysis results from the phase 3 LEAP-014 trial found that the addition of lenvatinib to pembrolizumab plus chemotherapy did not significantly improve survival among patients with previously untreated metastatic esophageal...
Second interim analysis results from the phase 3 LEAP-014 trial found that the addition of lenvatinib to pembrolizumab plus chemotherapy did not significantly improve survival among patients with previously untreated metastatic esophageal...
Second interim analysis results...
10/17/2025
Oncology
News
10/17/2025
Janelle Bradley
Anbenitamab plus chemotherapy significantly improved OS and PFS, with a threefold higher response rate vs chemotherapy alone, in patients with previously treated HER2-positive gastric or GEJ cancer.
Anbenitamab plus chemotherapy significantly improved OS and PFS, with a threefold higher response rate vs chemotherapy alone, in patients with previously treated HER2-positive gastric or GEJ cancer.
Anbenitamab plus chemotherapy...
10/17/2025
Oncology
News
10/17/2025
Janelle Bradley
The phase 3 MATTERHORN trial showed that adding durvalumab to perioperative FLOT significantly improved OS and EFS vs FLOT alone in resectable gastric and GEJ adenocarcinoma, with benefits observed regardless of PD-L1 status.
The phase 3 MATTERHORN trial showed that adding durvalumab to perioperative FLOT significantly improved OS and EFS vs FLOT alone in resectable gastric and GEJ adenocarcinoma, with benefits observed regardless of PD-L1 status.
The phase 3 MATTERHORN trial...
10/17/2025
Oncology
News
08/01/2025
Stephanie Holland
According to results from the phase 3 DESTINY-Gastric04 trial, trastuzumab deruxtecan in the second line significantly improved outcomes compared to ramucirumab plus paclitaxel among patients with HER2-positive unresectable or metastatic...
According to results from the phase 3 DESTINY-Gastric04 trial, trastuzumab deruxtecan in the second line significantly improved outcomes compared to ramucirumab plus paclitaxel among patients with HER2-positive unresectable or metastatic...
According to results from the...
08/01/2025
Oncology

Interactive Features

Quiz
10/17/2022
Do you know which chemotherapy regimen was found to be the standard first-line option for patients with advanced neuroendocrine carcinomas of the digestive system?
Do you know which chemotherapy regimen was found to be the standard first-line option for patients with advanced neuroendocrine carcinomas of the digestive system?
Do you know which chemotherapy...
10/17/2022
Oncology
Test Your Knowledge
09/08/2021
Which of the following uncommon cancers are classified as biliary tract cancers?
Which of the following uncommon cancers are classified as biliary tract cancers?
Which of the following uncommon...
09/08/2021
Oncology
Quiz
08/09/2021
True or false: The combination of atorvastatin and metformin have been shown to reduce the progression of chronic active hepatitis and cirrhosis to hepatocellular carcinoma, as well as increase the power of sorafenib, and develops a direct...
True or false: The combination of atorvastatin and metformin have been shown to reduce the progression of chronic active hepatitis and cirrhosis to hepatocellular carcinoma, as well as increase the power of sorafenib, and develops a direct...
True or false: The combination...
08/09/2021
Oncology
Test Your Knowledge
01/28/2021
True or false: Anlotinib has shown benefit in Chinese patients with refractory metastatic RAS/KRAS/BRAF-wildtype colorectal cancer.
True or false: Anlotinib has shown benefit in Chinese patients with refractory metastatic RAS/KRAS/BRAF-wildtype colorectal cancer.
True or false: Anlotinib has...
01/28/2021
Oncology
Test Your Knowledge
08/28/2020
True or false: Infigratinib did not yield a survival benefit in patients with cholangiocarcinoma and FGFR2 fusions.
True or false: Infigratinib did not yield a survival benefit in patients with cholangiocarcinoma and FGFR2 fusions.
True or false: Infigratinib did...
08/28/2020
Oncology
Test Your Knowledge
08/21/2020
True or false: In patients with unresectable PDGFRA D842V-Mutant GIST, avapritinib did not demonstrate meaningful activity.
True or false: In patients with unresectable PDGFRA D842V-Mutant GIST, avapritinib did not demonstrate meaningful activity.
True or false: In patients with...
08/21/2020
Oncology
Test Your Knowledge
08/21/2020
True or false: Classifying and differentiating tumor tissue from pure fibrosis during surgery for CRC is possible.
True or false: Classifying and differentiating tumor tissue from pure fibrosis during surgery for CRC is possible.
True or false: Classifying and...
08/21/2020
Oncology
Test Your Knowledge
07/31/2020
True or false: Overall survival disparity exists between the use of oxaliplatin and mitomycin C during CRS-HIPEC for colorectal peritoneal metastases.
True or false: Overall survival disparity exists between the use of oxaliplatin and mitomycin C during CRS-HIPEC for colorectal peritoneal metastases.
True or false: Overall survival...
07/31/2020
Oncology
Test Your Knowledge
06/22/2020
True or False: MDMs in plasma show promise as a method for accurately detecting distant recurrent CRC.
True or False: MDMs in plasma show promise as a method for accurately detecting distant recurrent CRC.
True or False: MDMs in plasma...
06/22/2020
Oncology
Test Your Knowledge
06/04/2020
True or False: Pembrolizumab should be the new standard of care for MSI-H/dMMR metastatic colorectal cancer?
True or False: Pembrolizumab should be the new standard of care for MSI-H/dMMR metastatic colorectal cancer?
True or False: Pembrolizumab...
06/04/2020
Oncology