According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
The phase 3 INDIGO trial enrolled previously untreated patients with residual or recurrent grade 2 IDH-mutant glioma to receive either vorasidenib or placebo. Which of the following statements best summarizes the primary clinical outcome of...
The phase 3 INDIGO trial enrolled previously untreated patients with residual or recurrent grade 2 IDH-mutant glioma to receive either vorasidenib or placebo. Which of the following statements best summarizes the primary clinical outcome of...
Stephen Bagley, MD, discusses results from a phase 1 dose-exploration study which assessed intracerebroventricular delivery of CART-EGFR-IL13Rα2 among patients with recurrent glioblastoma.
Stephen Bagley, MD, discusses results from a phase 1 dose-exploration study which assessed intracerebroventricular delivery of CART-EGFR-IL13Rα2 among patients with recurrent glioblastoma.
True or False: Concurrent temozolomide and radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients with non-codeleted anaplastic glioma.
True or False: Concurrent temozolomide and radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients with non-codeleted anaplastic glioma.
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.
Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.
Combination treatment using tumor treating fields with temozolomide, bevacizumab, and irinotecan chemotherapy improves OS in patients with recurrent glioblastoma with manageable safety.
Combination treatment using tumor treating fields with temozolomide, bevacizumab, and irinotecan chemotherapy improves OS in patients with recurrent glioblastoma with manageable safety.
Findings from a phase 2 study show feasibility of border zone stereotactic radiosurgery with bevacizumab for the treatment of patients with recurrent or progressive glioblastoma following conventional upfront management.
Findings from a phase 2 study show feasibility of border zone stereotactic radiosurgery with bevacizumab for the treatment of patients with recurrent or progressive glioblastoma following conventional upfront management.
According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
Stephen Bagley, MD, discusses results from a phase 1 dose-exploration study which assessed intracerebroventricular delivery of CART-EGFR-IL13Rα2 among patients with recurrent glioblastoma.
Stephen Bagley, MD, discusses results from a phase 1 dose-exploration study which assessed intracerebroventricular delivery of CART-EGFR-IL13Rα2 among patients with recurrent glioblastoma.
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
Combination treatment using tumor treating fields with temozolomide, bevacizumab, and irinotecan chemotherapy improves OS in patients with recurrent glioblastoma with manageable safety.
Combination treatment using tumor treating fields with temozolomide, bevacizumab, and irinotecan chemotherapy improves OS in patients with recurrent glioblastoma with manageable safety.
Findings from a phase 2 study show feasibility of border zone stereotactic radiosurgery with bevacizumab for the treatment of patients with recurrent or progressive glioblastoma following conventional upfront management.
Findings from a phase 2 study show feasibility of border zone stereotactic radiosurgery with bevacizumab for the treatment of patients with recurrent or progressive glioblastoma following conventional upfront management.
Claire Harrison, MD, shares results from the phase 3 MANIFEST-2 evaluating the clinical efficacy of pelabresib combined with ruxolitinib compared with ruxolitinib alone for patients with myelofibrosis naĂŻve to JAK inhibitor therapy.
Claire Harrison, MD, shares results from the phase 3 MANIFEST-2 evaluating the clinical efficacy of pelabresib combined with ruxolitinib compared with ruxolitinib alone for patients with myelofibrosis naĂŻve to JAK inhibitor therapy.
The implementation of R-ICE combined with genotype-guided therapy for the treatment of relapsed/refractory diffuse large B-cell lymphoma demonstrated clinical efficacy and safety in a phase 2 trial.
The implementation of R-ICE combined with genotype-guided therapy for the treatment of relapsed/refractory diffuse large B-cell lymphoma demonstrated clinical efficacy and safety in a phase 2 trial.
Treatment of R/R diffuse large B-cell lymphoma with PD-1/PD-L1 inhibitors alone showed consistent safety but limited efficacy, while combination treatment with CAR T-cell therapy demonstrated potential improved outcomes.
Treatment of R/R diffuse large B-cell lymphoma with PD-1/PD-L1 inhibitors alone showed consistent safety but limited efficacy, while combination treatment with CAR T-cell therapy demonstrated potential improved outcomes.
Compared with traditional salvage therapies, polatuzumab vedotin and zanubrutinib combined with rituximab or obinutuzumab demonstrated encouraging clinical efficacy for patients with relapsed/refractory diffuse large B-cell lymphoma.
Compared with traditional salvage therapies, polatuzumab vedotin and zanubrutinib combined with rituximab or obinutuzumab demonstrated encouraging clinical efficacy for patients with relapsed/refractory diffuse large B-cell lymphoma.
Pexidartinib showed sustained clinical benefit among patients with tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to surgery.
Pexidartinib showed sustained clinical benefit among patients with tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to surgery.
For patients with relapsed/refractory multiple myeloma, the combination of clarithromycin, ixazomib, pomalidomide, and dexamethasone demonstrated promising clinical efficacy and a manageable safety profile.
For patients with relapsed/refractory multiple myeloma, the combination of clarithromycin, ixazomib, pomalidomide, and dexamethasone demonstrated promising clinical efficacy and a manageable safety profile.
Results from the phase 2/3 GENERATE study demonstrated that neither mFOLFIRINOX nor S-IROX improved survival results compared to nab-paclitaxel plus gemcitabine among patients with recurrent or metastatic pancreatic cancer in the first-line...
Results from the phase 2/3 GENERATE study demonstrated that neither mFOLFIRINOX nor S-IROX improved survival results compared to nab-paclitaxel plus gemcitabine among patients with recurrent or metastatic pancreatic cancer in the first-line...
The phase 3 INDIGO trial enrolled previously untreated patients with residual or recurrent grade 2 IDH-mutant glioma to receive either vorasidenib or placebo. Which of the following statements best summarizes the primary clinical outcome of...
The phase 3 INDIGO trial enrolled previously untreated patients with residual or recurrent grade 2 IDH-mutant glioma to receive either vorasidenib or placebo. Which of the following statements best summarizes the primary clinical outcome of...
True or False: Concurrent temozolomide and radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients with non-codeleted anaplastic glioma.
True or False: Concurrent temozolomide and radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients with non-codeleted anaplastic glioma.
True or False: The small-molecular BET inhibitor INCB057643 demonstrated promising clinical activity and tolerability both as a monotherapy and combined with ruxolitinib for patients with relapsed/refractory myelofibrosis.
True or False: The small-molecular BET inhibitor INCB057643 demonstrated promising clinical activity and tolerability both as a monotherapy and combined with ruxolitinib for patients with relapsed/refractory myelofibrosis.
True or False: According to results from the EPCORE NHL-2 clinical trial, the addition of epcoritamab to standard R-ICE therapy demonstrated high overall and complete response rates among patients with R/R DLBCL eligible for autologous stem...
True or False: According to results from the EPCORE NHL-2 clinical trial, the addition of epcoritamab to standard R-ICE therapy demonstrated high overall and complete response rates among patients with R/R DLBCL eligible for autologous stem...
True or False: According to a phase 2 trial, the combination of amulirafusp alfa and lenalidomide demonstrated encouraging early clinical activity and an acceptable safety profile among patients with R/R CD20-positive follicular lymphoma.
True or False: According to a phase 2 trial, the combination of amulirafusp alfa and lenalidomide demonstrated encouraging early clinical activity and an acceptable safety profile among patients with R/R CD20-positive follicular lymphoma.
In the phase 2 PATCO trial assessing the addition of tocilizumab to gemcitabine plus nab-paclitaxel among patients with advanced pancreatic cancer, which statement best reflects the implications for clinical practice?
In the phase 2 PATCO trial assessing the addition of tocilizumab to gemcitabine plus nab-paclitaxel among patients with advanced pancreatic cancer, which statement best reflects the implications for clinical practice?
True or False: For patients with first-relapsed multiple myeloma, the addition of pomalidomide to bortezomib and dexamethasone demonstrated a significantly worse progression-free survival and overall response rate compared with control...
True or False: For patients with first-relapsed multiple myeloma, the addition of pomalidomide to bortezomib and dexamethasone demonstrated a significantly worse progression-free survival and overall response rate compared with control...
Dr Fawzi Abu Rous discussed the treatment of a 54-year-old patient who was diagnosed with an atypical case of small cell lung cancer. Which of the following features made this case atypical?
Dr Fawzi Abu Rous discussed the treatment of a 54-year-old patient who was diagnosed with an atypical case of small cell lung cancer. Which of the following features made this case atypical?
True or False: According to results from the ADORE clinical trial, ruxolitinib combined with siremadlin treatment demonstrated the least promising safety and efficacy for patients with myelofibrosis, compared with other novel agents in...
True or False: According to results from the ADORE clinical trial, ruxolitinib combined with siremadlin treatment demonstrated the least promising safety and efficacy for patients with myelofibrosis, compared with other novel agents in...
True or False: For patients with high-risk or R/R chronic lymphocytic leukemia, including those previously treated with pathway inhibitors, allogeneic hematopoietic stem cell transplantation demonstrated improved outcomes.
True or False: For patients with high-risk or R/R chronic lymphocytic leukemia, including those previously treated with pathway inhibitors, allogeneic hematopoietic stem cell transplantation demonstrated improved outcomes.
According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
According to results from a phase 2 trial, radiotherapy in addition to dual immune checkpoint blockade with ipilmumab and nivolumab failed to improve outcomes compared to radiotherapy plus single-agent temozolomide among newly diagnosed adult...
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 INDIGO trial, vorasidenib demonstrated clinical promise among patients with residual or recurrent grade 2 IDH-mutant glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from the phase 3 CATNON trial, concurrent temozolomide plus radiotherapy did not improve survival results compared to adjuvant temozolomide plus radiotherapy among patients without 1p/19p codeletion anaplastic glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
According to results from a phase 1/2 study, dordaviprone demonstrated clinical promise and safety among adult and pediatric patients with recurrent H3 K27M-mutated diffuse glioma.
The implementation of R-ICE combined with genotype-guided therapy for the treatment of relapsed/refractory diffuse large B-cell lymphoma demonstrated clinical efficacy and safety in a phase 2 trial.
The implementation of R-ICE combined with genotype-guided therapy for the treatment of relapsed/refractory diffuse large B-cell lymphoma demonstrated clinical efficacy and safety in a phase 2 trial.
Treatment of R/R diffuse large B-cell lymphoma with PD-1/PD-L1 inhibitors alone showed consistent safety but limited efficacy, while combination treatment with CAR T-cell therapy demonstrated potential improved outcomes.
Treatment of R/R diffuse large B-cell lymphoma with PD-1/PD-L1 inhibitors alone showed consistent safety but limited efficacy, while combination treatment with CAR T-cell therapy demonstrated potential improved outcomes.
Compared with traditional salvage therapies, polatuzumab vedotin and zanubrutinib combined with rituximab or obinutuzumab demonstrated encouraging clinical efficacy for patients with relapsed/refractory diffuse large B-cell lymphoma.
Compared with traditional salvage therapies, polatuzumab vedotin and zanubrutinib combined with rituximab or obinutuzumab demonstrated encouraging clinical efficacy for patients with relapsed/refractory diffuse large B-cell lymphoma.
Pexidartinib showed sustained clinical benefit among patients with tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to surgery.
Pexidartinib showed sustained clinical benefit among patients with tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to surgery.
For patients with relapsed/refractory multiple myeloma, the combination of clarithromycin, ixazomib, pomalidomide, and dexamethasone demonstrated promising clinical efficacy and a manageable safety profile.
For patients with relapsed/refractory multiple myeloma, the combination of clarithromycin, ixazomib, pomalidomide, and dexamethasone demonstrated promising clinical efficacy and a manageable safety profile.
Results from the phase 2/3 GENERATE study demonstrated that neither mFOLFIRINOX nor S-IROX improved survival results compared to nab-paclitaxel plus gemcitabine among patients with recurrent or metastatic pancreatic cancer in the first-line...
Results from the phase 2/3 GENERATE study demonstrated that neither mFOLFIRINOX nor S-IROX improved survival results compared to nab-paclitaxel plus gemcitabine among patients with recurrent or metastatic pancreatic cancer in the first-line...
According to a phase 2a trial, the novel anti-CSF1 receptor monoclonal antibody, AMB-05X, was found to have favorable pharmacokinetics, pharmacodynamics, efficacy, and safety among patients with tenosynovial giant cell tumors.
According to a phase 2a trial, the novel anti-CSF1 receptor monoclonal antibody, AMB-05X, was found to have favorable pharmacokinetics, pharmacodynamics, efficacy, and safety among patients with tenosynovial giant cell tumors.
According to an analysis of the FDA Adverse Events Reporting System (FAERS) database, the overall safety profile of pexidartinib was generally consistent with the clinical trial findings.
According to an analysis of the FDA Adverse Events Reporting System (FAERS) database, the overall safety profile of pexidartinib was generally consistent with the clinical trial findings.
According to results from the phase 2 E-BiTS study, intrapatient escalation of biweekly trifluridine/tipiracil plus bevacizumab demonstrated promising efficacy and safety among patients with advanced or unresectable metastatic colorectal...
According to results from the phase 2 E-BiTS study, intrapatient escalation of biweekly trifluridine/tipiracil plus bevacizumab demonstrated promising efficacy and safety among patients with advanced or unresectable metastatic colorectal...
