PV Guidelines Question 5
Transcript
The correct answer is ropeginterferon had more treatment-related adverse events than phlebotomy alone, but grades 3 and 4 adverse event rates were similar overall between groups. The rationale is as follows: In the low PV study, ropeginterferon exposure was associated with more treatment-related adverse events and some discontinuations versus phlebotomy only, but grade 3 and 4 event rates were similar between treatment groups overall. Notable events included neutropenia, elevated liver enzymes, and flu-like symptoms.
References
- Tremblay D, Kremyanskaya M, Mascarenhas J, Hoffman R. Diagnosis and treatment of polycythemia vera: a review. JAMA. 2025;333(2):153-160. doi:10.1001/jama.2024.20377
- Benevolo G, Vassallo F, Urbino I, Giai V. Polycythemia vera (PV): update on emerging treatment options. Ther Clin Risk Manag. 2021;17:209-221. doi:10.2147/TCRM.S213020
- Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Myeloproliferative Neoplasms V.1.2026. © National Comprehensive Cancer Network, Inc. 2026. All rights reserved. Accessed March 10, 2026. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
- Barbui T, Vannucchi AM, De Stefano V, et al. Ropeginterferon versus standard therapy for low-risk patients with polycythemia vera. NEJM Evid. 2023;2(6):EVIDoa2200335. doi:10.1056/EVIDoa2200335
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Dr Michael Grunwald is board-certified in internal medicine, hematology, and medical oncology, specializing in the treatment of hematologic malignancies. His clinical focus includes acute and chronic leukemias, myelodysplastic syndromes, and myeloproliferative neoplasms, as well as transplantation and cellular therapy. Dr Grunwald is actively involved in clinical trials focused on leukemia and allogeneic stem cell transplantation. He serves as chief of the Leukemia Section at Atrium Health Levine Cancer, Charlotte, NC, where he is also director of the Transplantation and Cellular Therapy Program. He is a professor of cancer medicine at Wake Forest University School of Medicine.
