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Taletrectinib for ROS1-Positive Non-Small Cell Lung Cancer

Geoffrey Liu, MD
11/05/2025


Geoffrey Liu, MD, Princess Margaret Cancer Centre, Toronto, Canada, discusses results from the phase 2 TRUST-2 trial evaluating taletrectinib in patients with ROS1-positive non-small cell lung cancer previously treated with entrectinib.

The study showed that taletrectinib produced durable response and strong intracranial activity with a manageable safety profile in this patient population. 

These findings were presented at the 2025 European Society for Medical Oncology (ESMO) Congress.

Source: 

Liu G. Safety and efficacy of IBTROZI™ (taletrectinib) as a treatment for patients with ROS1-positive (ROS1+) non-small cell lung cancer (NSCLC), including patients previously treated with entrectinib. Presented at the 2025 ESMO Congress. October 17-21, 2025; Berlin, Germany. 1986P

© 2025 HMP Global. All Rights Reserved.
Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Oncology Learning Network or HMP Global, their employees, and affiliates. 

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