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Zanzalintinib Plus Atezolizumab Extends Survival in Metastatic Colorectal Cancer

Anwaar Saeed, MD
11/05/2025


Anwaar Saeed, MD, University of Pittsburgh, Pittsburgh, Pennsylvania, discusses results from the phase 3 STELLAR-303 trial evaluating zanzalintinib plus atezolizumab versus regorafenib in patients with chemorefractory metastatic colorectal cancer who are not MSI-high or mismatch repair deficient.

Results demonstrate that the combination significantly improves overall survival compared with standard therapy, with consistent benefit across key subgroups and a favorable safety profile.

These results were presented at the 2025 European Society for Medical Oncology (ESMO) Congress in Berlin, Germany.

Source: 

Saeed A, Park SY, Tabernero J, et al. Zanzalintinib plus atezolizumab (zanza + atezo) vs regorafenib (rego) in patients (pts) with previously treated metastatic colorectal cancer (mCRC): Primary overall survival (OS) analysis from the randomized, open-label, phase 3 STELLAR-303 study. Presented at the 2025 ESMO Congress. October 17-21, 2025; Berlin, Germany. LBA30

© 2025 HMP Global. All Rights Reserved.
Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Oncology Learning Network or HMP Global, their employees, and affiliates. 

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