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Clinical Differences Among Oral SERDs in HR-Positive, HER2-Negative Breast Cancer

03/20/2026

 

At Great Debates Solid Tumors in Miami, Florida, Sarah Premji, MD, from Sarah Cannon Research Institute, Nashville, Tennessee, discusses whether emerging oral selective estrogen receptor degraders (SERDs) differ in HR-positive, HER2-negative breast cancer. 

Dr Premji highlights differences in molecular structure, pharmacologic activity, toxicity profiles, and clinical development pathways across agents, while emphasizing the importance of biomarker-driven strategies and combination approaches to optimize endocrine therapy sequencing.

 

Source:

Premji S. Oral SERDs in breast cancer: They’re all the same: Yes vs no. Presented at Great Debates - Solid Tumors; Miami, Florida. March 14-15, 2026. 

© 2026 HMP Global. All Rights Reserved.
Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of LL&M, Oncology Learning Network or HMP Global, their employees, and affiliates.

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