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Definitive Liver Radiotherapy for Intrahepatic Cholangiocarcinoma With Extrahepatic Metastases

11/27/2023

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Lirafugratinib Demonstrates Efficacy, Safety for Previously Treated Patients With FGFR2 Fusion-Positive Cholangiocarcinoma
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Results from the phase 1/2 ReFocus study show that lirafugratinib demonstrates promising efficacy and safety among FGFR inhibitor-naive patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusions or rearrangements.
Results from the phase 1/2 ReFocus study show that lirafugratinib demonstrates promising efficacy and safety among FGFR inhibitor-naive patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusions or rearrangements.
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Zenocutuzumab Demonstrates Durable Efficacy for Patients With NRG1-Positive Cholangiocarcinoma
12/02/2025
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According to updated results from the ongoing, phase 2 eNRGy trial, zenocutuzumab demonstrated durable efficacy and safety among patients with NRG1-positive cholangiocarcinoma.
According to updated results from the ongoing, phase 2 eNRGy trial, zenocutuzumab demonstrated durable efficacy and safety among patients with NRG1-positive cholangiocarcinoma.
According to updated results...
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Quiz
Zenocutuzumab for Advanced NRG1-Mutated Cholangiocarcinoma
11/17/2025
Based on results from the phase 2 eNRGy trial, the FDA granted Breakthrough Therapy designation to zenocutuzumab for patients with advanced NRG1-mutated cholangiocarcinoma. Which of the following statements best summarizes the eNRGy trial...
Based on results from the phase 2 eNRGy trial, the FDA granted Breakthrough Therapy designation to zenocutuzumab for patients with advanced NRG1-mutated cholangiocarcinoma. Which of the following statements best summarizes the eNRGy trial...
Based on results from the phase...
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Videos
Zenocutuzumab Demonstrates Durable Responses in NRG1 Fusion-Positive Cholangiocarcinoma
11/05/2025
Alison Schram, MD
Alison Schram, MD, discusses results from the phase 2 eNRGy trial evaluating zenocutuzumab in patients with advanced NRG1 fusion–positive cholangiocarcinoma.
Alison Schram, MD, discusses results from the phase 2 eNRGy trial evaluating zenocutuzumab in patients with advanced NRG1 fusion–positive cholangiocarcinoma.
Alison Schram, MD, discusses...
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Incidence of Cutaneous Squamous Cell Carcinoma and Carcinoma in Situ Continues to Rise
01/29/2026
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Results from a real-world analysis have demonstrated that the incidence of cutaneous squamous cell carcinoma and cutaneous squamous cell carcinoma in situ has steadily increased over the past 2 decades, emphasizing the need for monitoring...
Results from a real-world analysis have demonstrated that the incidence of cutaneous squamous cell carcinoma and cutaneous squamous cell carcinoma in situ has steadily increased over the past 2 decades, emphasizing the need for monitoring...
Results from a real-world...
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Elenagen Plus Gemcitabine Improves Overall Survival for Patients With Platinum-Resistant Ovarian Cancer
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The addition of elenagen to gemcitabine therapy significantly prolonged overall survival among patients with platinum-resistant ovarian cancer without increasing toxicity, according to results from a phase 2 trial.
The addition of elenagen to gemcitabine therapy significantly prolonged overall survival among patients with platinum-resistant ovarian cancer without increasing toxicity, according to results from a phase 2 trial.
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Axicabtagene Ciloleucel Plus Atezolizumab Demonstrates Promise in Relapsed/Refractory Large B-Cell Lymphoma
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Results from the phase 1/2 ZUMA-6 trial showed that the addition of atezolizumab to axicabtagene ciloleucel showed promising clinical activity among patients with relapsed or refractory large B-cell lymphoma.
Results from the phase 1/2 ZUMA-6 trial showed that the addition of atezolizumab to axicabtagene ciloleucel showed promising clinical activity among patients with relapsed or refractory large B-cell lymphoma.
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Tucatinib plus trastuzumab provided durable responses and a favorable safety profile among patients with chemotherapy-refractory, HER2positive metastatic colorectal cancer, based on results from the phase 2 MOUNTAINEER trial.
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TOMOX-Bevacizumab Combination Shows Feasibility as Second-Line Therapy in mCRC
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A TOMOX-bevacizumab combination demonstrated an acceptable safety profile as a second-line treatment for patients with metastatic colorectal cancer progressing after irinotecan-based chemotherapy, according to a phase 2 study.
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A translational study identified ISL1 as a potential predictive biomarker in small cell lung cancer, defining a subtype with enhanced sensitivity to lurbinectedin and supporting biomarker-driven patient selection in future trials.
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Systemic CSF-1R inhibition provides an effective option for unresectable or recurrent tenosynovial giant cell tumor, with safety and tolerability favoring newer agents and potentially shifting first-line treatment paradigms.
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Systemic CSF-1R inhibition...
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Sacituzumab Govitecan Plus Pembrolizumab Significantly Prolongs PFS in PD-L1-Positive Triple-Negative Breast Cancer
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Anbenitamab Plus Chemotherapy After Trastuzumab Failure in HER2-Positive G/GEJ Cancer
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Results from a multicenter, phase 3 trial demonstrated that anbenitamab plus chemotherapy improved survival compared with placebo plus chemotherapy among previously treated patients with HER2-positive gastric or gastroesophageal junction...
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