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Conference Coverage

OLYMPIA-3 Trial: Odronextamab With CHOP Demonstrates Strong Efficacy and Manageable Safety for Patients With Newly Diagnosed DLBCL

Jean-Marie Michot, MD
12/07/2025

 

According to results from the phase 3 OLYMPIA-3 trial presented by Jean-Marie Michot, MD, Gustave Roussy, Villejuif, France, at the 2025 American Society of Hematology (ASH) Annual Meeting & Exposition in Orlando, Florida, the combination of bispecific antibody odronextamab with cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone (CHOP) chemotherapy achieved high response rates and manageable toxicity among patients with previously untreated diffuse large B-cell lymphoma (DLBCL).

The OLYMPIA-3 study consists of part 1A (dose escalation) and part 1B (dose optimization). Here, Dr Michot comments on the results from part 1A. 

 

Source:

Michot JM, Yagci M, Kargus K, et al. Odronextamab plus chemotherapy in patients with previously untreated diffuse large B-cell lymphoma (DLBCL): First Results from part 1 of the Phase 3 Olympia-3 study. Dec 6-9, 2025; Orlando, FL. Abstract: 65

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Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of LL&M, Oncology Learning Network or HMP Global, their employees, and affiliates.

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