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Crohn's Disease

Featured Content

Research Highlights
Guselkumab Dose Escalation Shows Sustained Benefit in Crohn’s Disease
05/13/2026
Rebecca Mashaw
GALAXI 2 and 3 extension data suggest that escalating guselkumab maintenance dosing may safely improve clinical and endoscopic outcomes in Crohn’s disease patients with inadequate response.
GALAXI 2 and 3 extension data suggest that escalating guselkumab maintenance dosing may safely improve clinical and endoscopic outcomes in Crohn’s disease patients with inadequate response.
GALAXI 2 and 3 extension data...
05/13/2026
Advances in Inflammatory Bowel Disease Network
Research Highlights
PROFILE Study Confirms Early “Top-Down” Therapy Reduces Long-Term Complications in Crohn’s Disease
05/13/2026
Jessica Garlewicz
Disease progression was more common in the cohort on step-up therapy, with higher rates of stricturing and penetrating complications and hospitalizations.
Disease progression was more common in the cohort on step-up therapy, with higher rates of stricturing and penetrating complications and hospitalizations.
Disease progression was more...
05/13/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Subcutaneous Infliximab Effective Across Ileal and Colonic Crohn’s Disease
05/01/2026
Jessica Garlewicz
Post-hoc analysis shows that endoscopic responses to subcutaneous infliximab were observed across all intestinal segments, including the terminal ileum.
Post-hoc analysis shows that endoscopic responses to subcutaneous infliximab were observed across all intestinal segments, including the terminal ileum.
Post-hoc analysis shows that...
05/01/2026
AIBD NP/PA Institute
From AIBD NP/PA Institute
Research Highlights
Infliximab and Ustekinumab Show Comparable Effectiveness in Biologic-Naïve Crohn’s Disease
01/14/2026
Jessica Garlewicz
Endoscopic response, transmural remission, and transmural response rates showed no significant differences between treatment groups at either assessment window.
Endoscopic response, transmural remission, and transmural response rates showed no significant differences between treatment groups at either assessment window.
Endoscopic response, transmural...
01/14/2026
Advances in Inflammatory Bowel Disease Network
Research Highlights
Upadacitinib Improves Outcomes in Fistulizing Crohn’s Disease
09/04/2025
Rebecca Mashaw
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing...
09/04/2025
Advances in Inflammatory Bowel Disease Network
News
Validation of a Simple Ultrasound Score for Crohn’s Disease
08/28/2025
Rebecca Mashaw
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the...
08/28/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Real-World Effectiveness and Safety of Risankizumab in Crohn’s Disease
08/21/2025
Rebecca Mashaw
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates...
08/21/2025
Advances in Inflammatory Bowel Disease Network
News
Terminal Ileum Resection in Crohn’s Disease Linked to Increased Colorectal Cancer Risk
07/29/2025
Jessica Garlewicz
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to...
07/29/2025
Gastroenterology
From Gastroenterology
Research Highlights
Advanced Therapies Show Greater Efficacy in Colonic vs Ileal Crohn’s Disease
07/24/2025
Rebecca Mashaw
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Guselkumab Induction and SC Maintenance Shows Efficacy and Safety in Crohn’s Disease
07/24/2025
Rebecca Mashaw
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Stricture-Related Resections Rising in Crohn’s Disease Despite Overall Decline in Surgical Rates
05/29/2025
Jessica Garlewicz
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess...
05/29/2025
Advances in Inflammatory Bowel Disease Network

News

Research Highlights
Upadacitinib Improves Outcomes in Fistulizing Crohn’s Disease
09/04/2025
Rebecca Mashaw
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing...
09/04/2025
Advances in Inflammatory Bowel Disease Network
News
Validation of a Simple Ultrasound Score for Crohn’s Disease
08/28/2025
Rebecca Mashaw
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the...
08/28/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Real-World Effectiveness and Safety of Risankizumab in Crohn’s Disease
08/21/2025
Rebecca Mashaw
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates...
08/21/2025
Advances in Inflammatory Bowel Disease Network
News
Terminal Ileum Resection in Crohn’s Disease Linked to Increased Colorectal Cancer Risk
07/29/2025
Jessica Garlewicz
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to...
07/29/2025
Gastroenterology
Research Highlights
Advanced Therapies Show Greater Efficacy in Colonic vs Ileal Crohn’s Disease
07/24/2025
Rebecca Mashaw
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Guselkumab Induction and SC Maintenance Shows Efficacy and Safety in Crohn’s Disease
07/24/2025
Rebecca Mashaw
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Stricture-Related Resections Rising in Crohn’s Disease Despite Overall Decline in Surgical Rates
05/29/2025
Jessica Garlewicz
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess...
05/29/2025
Advances in Inflammatory Bowel Disease Network
News
Early Response to Upadacitinib Predicts Long-Term Improvements in Crohn’s Disease
04/03/2025
Jessica Garlewicz
Patients with early response achieved higher rates of clinical remission and reductions in fatigue and impairment.
Patients with early response achieved higher rates of clinical remission and reductions in fatigue and impairment.
Patients with early response...
04/03/2025
Advances in Inflammatory Bowel Disease Network
News
MASLD Linked to Worse Clinical Outcomes in Hospitalized Crohn’s Disease Patients
04/03/2025
Jessica Garlewicz
A new study examined 792,409 hospitalizations for Crohn's disease, of which 26,229 (3.3%) involved patients with coexisting metabolic dysfunction-associated steatotic liver disease.
A new study examined 792,409 hospitalizations for Crohn's disease, of which 26,229 (3.3%) involved patients with coexisting metabolic dysfunction-associated steatotic liver disease.
A new study examined 792,409...
04/03/2025
Gastroenterology
News
VCE-Guided Treat-to-Target Strategy Reduces Flares in Crohn’s Disease Remission
04/01/2025
Jessica Garlewicz
The study highlights the utility of mucosal assessment in driving treatment optimization, even in asymptomatic patients.
The study highlights the utility of mucosal assessment in driving treatment optimization, even in asymptomatic patients.
The study highlights the utility...
04/01/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Combined Ultrasound and Calprotectin at 3 Months Predict Postoperative Recurrence in Crohn’s Disease
05/07/2026
Jessica Garlewicz
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive...
05/07/2026
Advances in Inflammatory Bowel Disease Network
News
Oral Icotrokinra Demonstrates Efficacy in Ulcerative Colitis Regardless of Prior Advanced Therapy Exposure
05/05/2026
Jessica Garlewicz
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Early “Top-Down” Therapy Reduces Long-Term Complications in Crohn’s Disease
05/05/2026
Jessica Garlewicz
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Upper GI Crohn’s Disease Remains Underrecognized, Lacks Standardized Guidance
04/02/2026
Jessica Garlewicz
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of...
04/02/2026
Advances in Inflammatory Bowel Disease Network
Research Summary
Advanced Therapy May Reduce Antibiotic Dependence in Chronic Pouchitis After IPAA
03/18/2026
Jessica Garlewicz
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support...
03/18/2026
Advances in Inflammatory Bowel Disease Network
Research Review
New Meta-Analysis Highlights Burden of MASLD Among IBD Patients
02/03/2026
Rebecca Mashaw
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from...
02/03/2026
Gastroenterology
News
Medicare Will Cover GLP-1s for Obesity Under Deal with Pharma
11/06/2025
Rebecca Mashaw
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said...
11/06/2025
Advances in Inflammatory Bowel Disease Network
FDA alert
FDA Alert
FDA Approves Updated Indication for Upadacitinib in IBD
10/14/2025
Rebecca Mashaw
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for...
10/14/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Concomitant Medications Do Not Alter Efficacy of Advanced Therapies in Ulcerative Colitis, Study Finds
09/18/2025
Jessica Garlewicz
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that...
09/18/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Persistent Prothrombotic State Observed in Patients With ASUC
09/04/2025
Rebecca Mashaw
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with...
09/04/2025
Advances in Inflammatory Bowel Disease Network

Interactive Features

Quiz
Risk Factors for Surgery in Crohn’s Disease
02/26/2025
Rebecca Mashaw
Estimates vary but indicate that half or more of patients with Crohn's disease will require surgery at some point in their disease course. Do you know which factors place your patients at high risk for surgery? Take our quiz to find out!
Estimates vary but indicate that half or more of patients with Crohn's disease will require surgery at some point in their disease course. Do you know which factors place your patients at high risk for surgery? Take our quiz to find out!
Estimates vary but indicate that...
02/26/2025
Advances in Inflammatory Bowel Disease Network
medical quiz
Quiz
Surgical Outcomes for Crohn's Disease vs Ulcerative Colitis
07/14/2023
Priyam Vora
Are surgical outcomes the same for patients with Crohn's disease as they are for patients with ulcerative colitis? Find out with a quick quiz.
Are surgical outcomes the same for patients with Crohn's disease as they are for patients with ulcerative colitis? Find out with a quick quiz.
Are surgical outcomes the same...
07/14/2023
Advances in Inflammatory Bowel Disease Network
doc writing notes
Quiz
SIBO and Crohn's Disease
04/28/2023
Rebecca Mashaw
Is there any link between small intestinal bacterial overgrowth and clinical relapse in patients with quiescent Crohn disease? Take the test to find out!
Is there any link between small intestinal bacterial overgrowth and clinical relapse in patients with quiescent Crohn disease? Take the test to find out!
Is there any link between small...
04/28/2023
Advances in Inflammatory Bowel Disease Network
Quiz
Terminal Ileal Resection and CRC Risk
08/07/2025
Rebecca Mashaw
Is terminal ileum resection in patients with Crohn’s disease associated with colorectal cancer risk? See what recent research found by taking our quiz.
Is terminal ileum resection in patients with Crohn’s disease associated with colorectal cancer risk? See what recent research found by taking our quiz.
Is terminal ileum resection in...
08/07/2025
Gastroenterology
Quiz
Does Hormone Replacement Therapy Affect IBD?
07/18/2025
Can hormone replacement therapy help or harm disease activity among women with IBD? Our quiz will show the answer!
Can hormone replacement therapy help or harm disease activity among women with IBD? Our quiz will show the answer!
Can hormone replacement therapy...
07/18/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Can Perspiration Reveal IBD Biomarkers?
07/18/2025
Can a wearable sensor help monitor disease activity in IBD--via sweat? Take our quiz to get the answer.
Can a wearable sensor help monitor disease activity in IBD--via sweat? Take our quiz to get the answer.
Can a wearable sensor help...
07/18/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Making EHRs Work
07/01/2025
Rebecca Mashaw
Which of the following factors did clinicians say in a recent study is particularly important for EHR functionality in the context of IBD?
Which of the following factors did clinicians say in a recent study is particularly important for EHR functionality in the context of IBD?
Which of the following factors...
07/01/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Do EHRs Help or Hinder in IBD Care?
07/01/2025
Rebecca Mashaw
According to a recent survey of clinicians who care for patients with inflammatory bowel disease, what percentage reported that their EHR system does not enhance patient care in IBD?
According to a recent survey of clinicians who care for patients with inflammatory bowel disease, what percentage reported that their EHR system does not enhance patient care in IBD?
According to a recent survey of...
07/01/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Advanced Combination Treatment for Refractory IBD
07/01/2025
Rebecca Mashaw
A multicenter Canadian study to evaluate advanced combination treatment (ACT) in patients with refractory inflammatory bowel disease (IBD) arrived at which of the following conclusions?
A multicenter Canadian study to evaluate advanced combination treatment (ACT) in patients with refractory inflammatory bowel disease (IBD) arrived at which of the following conclusions?
A multicenter Canadian study to...
07/01/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Biomarkers in Perspiration
07/01/2025
A recent study evaluated the use of a wearable sensor to measure inflammatory biomarkers in perspiration as a noninvasive method for monitoring IBD activity. What did it show? Take our quiz to see if you know the answer!
A recent study evaluated the use of a wearable sensor to measure inflammatory biomarkers in perspiration as a noninvasive method for monitoring IBD activity. What did it show? Take our quiz to see if you know the answer!
A recent study evaluated the use...
07/01/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Hormone Replacement Impact on IBD
05/22/2025
Rebecca Mashaw
Does hormone replacement therapy have any effect on treatment for IBD among postmenopausal women? Take our quiz to find out!
Does hormone replacement therapy have any effect on treatment for IBD among postmenopausal women? Take our quiz to find out!
Does hormone replacement therapy...
05/22/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Upper GI Crohn's Disease
03/18/2025
Rebecca Mashaw
How much do you know about upper GI Crohn's disease? Take our quiz to check your knowledge!
How much do you know about upper GI Crohn's disease? Take our quiz to check your knowledge!
How much do you know about upper...
03/18/2025
Advances in Inflammatory Bowel Disease Network
Quiz
Preoperative Nutrition for Crohn’s Disease Patients
03/18/2025
Rebecca Mashaw
What is one benefit of preoperative exclusive enteral nutrition for Crohn’s disease patients? Take our quiz to find out if you know the answer!
What is one benefit of preoperative exclusive enteral nutrition for Crohn’s disease patients? Take our quiz to find out if you know the answer!
What is one benefit of...
03/18/2025
Advances in Inflammatory Bowel Disease Network

Insights

Miguel Regueiro MD
Conference coverage
Miguel Regueiro, MD, on Updates in Treatment of Perianal Crohn's Disease
05/12/2025
Miguel D. Regueiro, MD
Dr Regueiro reviews his presentation of the Patricia and Ralph Gianella lecture from DDW 2025 on the updates to the treatment algorithm for perianal Crohn's disease.
Dr Regueiro reviews his presentation of the Patricia and Ralph Gianella lecture from DDW 2025 on the updates to the treatment algorithm for perianal Crohn's disease.
Dr Regueiro reviews his...
05/12/2025
Advances in Inflammatory Bowel Disease Network
Ed Barnes
Conference coverage
Edward Barnes, MD, on Penetrating and Stricturing Crohn's Disease
05/09/2025
Edward L. Barnes
Dr Barnes reviews the key points of his presentation from the AIBD regional meeting on managing penetrating and stricturing complications of Crohn's disease.
Dr Barnes reviews the key points of his presentation from the AIBD regional meeting on managing penetrating and stricturing complications of Crohn's disease.
Dr Barnes reviews the key points...
05/09/2025
Advances in Inflammatory Bowel Disease Network
Marla Dubinsky
Conference coverage
Marla Dubinsky, MD, on Risk Stratification in Crohn's Disease
01/16/2025
Dr Dubinsky opened the 2024 Advances in Inflammatory Bowel Disease conference with a firm statement that virtually all patients with Crohn's disease should be treated quickly after diagnosis with approved and effective therapies to help...
Dr Dubinsky opened the 2024 Advances in Inflammatory Bowel Disease conference with a firm statement that virtually all patients with Crohn's disease should be treated quickly after diagnosis with approved and effective therapies to help...
Dr Dubinsky opened the 2024...
01/16/2025
Advances in Inflammatory Bowel Disease Network
Anthony de Buck
Conference coverage
Anthony de Buck, MD, on Positioning Surgery for Crohn's Disease
12/10/2024
Dr de Buck explains how early surgery may be an excellent option in Crohn's disease, when to provide adjuvant medical therapy, monitoring patients after procedures, and that the type of surgery is less important than the timing.
Dr de Buck explains how early surgery may be an excellent option in Crohn's disease, when to provide adjuvant medical therapy, monitoring patients after procedures, and that the type of surgery is less important than the timing.
Dr de Buck explains how early...
12/10/2024
Advances in Inflammatory Bowel Disease Network
Jim Lewis
Videos
James Lewis, MD, on Diet and Nutrition in Crohn's Disease
12/09/2024
James D. Lewis
Dr James Lewis, from the University of Pennsylvania, recaps his presentation on using diet as an adjunct to medical therapy for Crohn's disease, and its potential to induce remission and even prevent IBD among those at high risk.
Dr James Lewis, from the University of Pennsylvania, recaps his presentation on using diet as an adjunct to medical therapy for Crohn's disease, and its potential to induce remission and even prevent IBD among those at high risk.
Dr James Lewis, from the...
12/09/2024
Advances in Inflammatory Bowel Disease Network
Video
Remo Panaccione, MD, on the GRAVITI Trials of Guselkumab in Crohn's Disease
12/02/2024
Dr Panaccione reviews the latest trial results for guselkumab in treating Crohn's disease, showing that both IV and subcutaneous induction are superior to placebo.
Dr Panaccione reviews the latest trial results for guselkumab in treating Crohn's disease, showing that both IV and subcutaneous induction are superior to placebo.
Dr Panaccione reviews the latest...
12/02/2024
Advances in Inflammatory Bowel Disease Network
Phillip Gu
Video
Phillip Gu, MD, on Preventing Postoperative Crohn's Disease Recurrence
09/11/2024
Dr Gu reviews his address at the AIBD regional meeting on the recurrence of postoperative Crohn's disease, including how to assess risks and steps that can help to prevent it.
Dr Gu reviews his address at the AIBD regional meeting on the recurrence of postoperative Crohn's disease, including how to assess risks and steps that can help to prevent it.
Dr Gu reviews his address at the...
09/11/2024
Advances in Inflammatory Bowel Disease Network
Florian Rieder
Video
Florian Rieder, MD, on Optimizing Outcomes in Crohn's Disease
08/21/2024
Dr Rieder reviews the options for treatment of Crohn's disease in terms of safety, treatment of comorbidities, and efficacy for moderate to severe disease.
Dr Rieder reviews the options for treatment of Crohn's disease in terms of safety, treatment of comorbidities, and efficacy for moderate to severe disease.
Dr Rieder reviews the options...
08/21/2024
Advances in Inflammatory Bowel Disease Network
Ed Loftus
Video
Edward Loftus, MD, on Upadacitinib in Crohn's Disease
06/06/2024
Dr Loftus recaps his poster presentation on a subanalysis from the upadacitinib phase 3 trials in Crohn's disease examining the effect on anxiety, depression, fatigue, and bowel urgency.
Dr Loftus recaps his poster presentation on a subanalysis from the upadacitinib phase 3 trials in Crohn's disease examining the effect on anxiety, depression, fatigue, and bowel urgency.
Dr Loftus recaps his poster...
06/06/2024
Advances in Inflammatory Bowel Disease Network
Miguel D. Regueiro
Conference Coverage
Miguel Regueiro, MD, on Postoperative Crohn's Disease
05/15/2024
Miguel D. Regueiro, MD
Dr Regueiro recaps his keynote address on the management postoperative Crohn's disease, including new surgical techniques and medications that could help prevent the occurrence of postoperative disease.
Dr Regueiro recaps his keynote address on the management postoperative Crohn's disease, including new surgical techniques and medications that could help prevent the occurrence of postoperative disease.
Dr Regueiro recaps his keynote...
05/15/2024
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Jennifer Seminerio, MD, on Advanced Combination Therapy
06/12/2026
Raymond Cross, MD; Jennifer Seminerio, MD
Drs Cross and Seminerio discuss advanced combination therapy, which involves use of more than one biologic or a biologic and an advanced small molecule, including trial results to date, types of combinations, safety considerations, and which...
Drs Cross and Seminerio discuss advanced combination therapy, which involves use of more than one biologic or a biologic and an advanced small molecule, including trial results to date, types of combinations, safety considerations, and which...
Drs Cross and Seminerio discuss...
06/12/2026
Advances in Inflammatory Bowel Disease Network
Gil Melmed
Conference Coverage
Gil Melmed, MD, on Prehabilitation Among IBD Surgical Patients
06/01/2026
Gil Y. Melmed, MD
Dr Melmed reviews the prehabilitation protocol trialed at Cedars-Sinai among patients with IBD who were preparing for surgery, which showed a definite reduction in complications among the cohort that received multidisciplinary care as well as...
Dr Melmed reviews the prehabilitation protocol trialed at Cedars-Sinai among patients with IBD who were preparing for surgery, which showed a definite reduction in complications among the cohort that received multidisciplinary care as well as...
Dr Melmed reviews the...
06/01/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Jordan Axelrad, MD, on Communicating Risks to Patients With IBD
05/22/2026
Raymond Cross, MD; Jordan Axelrad, MD
Drs Raymond Cross and Jordan Axelrad provide guidance to clinicians about the best ways to put risks—both of uncontrolled IBD and of therapies—into perspective for patients.
Drs Raymond Cross and Jordan Axelrad provide guidance to clinicians about the best ways to put risks—both of uncontrolled IBD and of therapies—into perspective for patients.
Drs Raymond Cross and Jordan...
05/22/2026
Advances in Inflammatory Bowel Disease Network
Bruce Sands
Expert Insights
Bruce Sands, MD, on Results from DUET-CD
05/19/2026
Bruce E. Sands, MD, MS
Dr Sands reviews the results of the DUET-CD study of combination therapy with guselkumab and golimumab in patients with Crohn's disease, which showed a significant increase in efficacy for the combination versus either drug independently.
Dr Sands reviews the results of the DUET-CD study of combination therapy with guselkumab and golimumab in patients with Crohn's disease, which showed a significant increase in efficacy for the combination versus either drug independently.
Dr Sands reviews the results of...
05/19/2026
Advances in Inflammatory Bowel Disease Network
Maria Abreu
Research Insights
Maria Abreu, MD, on the DUET-UC Trial of Combination Therapy
05/19/2026
Maria Abreu, MD
Dr Abreu recaps the results of a late breaking abstract from Digestive Disease Week on the DUET-UC study, which tested whether a combination of two advanced therapies showed an additive or synergistic effect in patients refractory ulcerative...
Dr Abreu recaps the results of a late breaking abstract from Digestive Disease Week on the DUET-UC study, which tested whether a combination of two advanced therapies showed an additive or synergistic effect in patients refractory ulcerative...
Dr Abreu recaps the results of a...
05/19/2026
Advances in Inflammatory Bowel Disease Network
Miguel Regueiro MD
Research Review
Miguel Regueiro, MD, on Therapies for Perianal Crohn's Disease
05/13/2026
Miguel D. Regueiro, MD
Dr Regueiro reviews his presentation from Digestive Disease Week on the treatment of perianal Crohn's disease, including advances in medical therapies and surgical approaches. 
Dr Regueiro reviews his presentation from Digestive Disease Week on the treatment of perianal Crohn's disease, including advances in medical therapies and surgical approaches. 
Dr Regueiro reviews his...
05/13/2026
Advances in Inflammatory Bowel Disease Network
Stephen Hanauer
Conference Coverage
Stephen Hanauer, MD, on Themes in IBD at DDW
05/07/2026
Stephen B. Hanauer, MD
Dr Hanauer reviews the key themes that were discussed in sessions on inflammatory bowel diseases at Digestive Diseases Week 2026, including prevention, early treatment, and combination therapy.
Dr Hanauer reviews the key themes that were discussed in sessions on inflammatory bowel diseases at Digestive Diseases Week 2026, including prevention, early treatment, and combination therapy.
Dr Hanauer reviews the key...
05/07/2026
Advances in Inflammatory Bowel Disease Network
Jean-Frederic Colombel
Expert Insights
Jean-Frederic Colombel, MD, on Disease Clearance With Mirikizumab in Ulcerative Colitis
05/06/2026
Jean-Frederic Colombel
Dr Colombel discusses his presentation at DDW 2026 on a post-doc analysis of the long-term outcomes of the LUCENT trial of mirikizumab, which showed that the IL-23p19 inhibitor achieved and maintained disease clearance for up to 4 years among...
Dr Colombel discusses his presentation at DDW 2026 on a post-doc analysis of the long-term outcomes of the LUCENT trial of mirikizumab, which showed that the IL-23p19 inhibitor achieved and maintained disease clearance for up to 4 years among...
Dr Colombel discusses his...
05/06/2026
Advances in Inflammatory Bowel Disease Network
Ed Barnes
Conference Coverage
Edward Barnes, MD on the VIVID Trials of Mirikizumab in Bio-Exposed Patients With Crohn's Disease
05/06/2026
Edward L. Barnes, MD
Dr Barnes reviewed his presentation of results from the VIVID 1 and VIVID 2 trials of mirkizumab in patients with Crohn's disease with exposure to anti-TNF therapy, which found that 65% of those in endoscopic response at week 52 maintained...
Dr Barnes reviewed his presentation of results from the VIVID 1 and VIVID 2 trials of mirkizumab in patients with Crohn's disease with exposure to anti-TNF therapy, which found that 65% of those in endoscopic response at week 52 maintained...
Dr Barnes reviewed his...
05/06/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Colleen Kelly, MD, on Obesity and IBD
04/20/2026
Raymond Cross, MD; Colleen Kelly, MD
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on...
04/20/2026
Advances in Inflammatory Bowel Disease Network

Latest News

Research Highlights
Upadacitinib Improves Outcomes in Fistulizing Crohn’s Disease
09/04/2025
Rebecca Mashaw
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing Crohn’s disease achieved higher rates of fistula resolution and clinical response with upadacitinib versus placebo.
Patients with fistulizing...
09/04/2025
Advances in Inflammatory Bowel Disease Network
News
Validation of a Simple Ultrasound Score for Crohn’s Disease
08/28/2025
Rebecca Mashaw
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the accuracy and reliability of a simplified ultrasound score for assessing Crohn’s disease activity.
A multicenter study confirms the...
08/28/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Real-World Effectiveness and Safety of Risankizumab in Crohn’s Disease
08/21/2025
Rebecca Mashaw
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates sustained clinical benefit and favorable safety in Crohn’s disease, including among ustekinumab-experienced patients.
Risankizumab demonstrates...
08/21/2025
Advances in Inflammatory Bowel Disease Network
News
Terminal Ileum Resection in Crohn’s Disease Linked to Increased Colorectal Cancer Risk
07/29/2025
Jessica Garlewicz
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to explore the underlying mechanisms and to refine screening strategies based on individualized risk.
Further studies are warranted to...
07/29/2025
Gastroenterology
Research Highlights
Advanced Therapies Show Greater Efficacy in Colonic vs Ileal Crohn’s Disease
07/24/2025
Rebecca Mashaw
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14 randomized clinical trials, Janus kinase inhibitors and other advanced therapies demonstrated significantly higher efficacy in colonic compared to ileal Crohn’s disease.
In a meta-analysis of 14...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Guselkumab Induction and SC Maintenance Shows Efficacy and Safety in Crohn’s Disease
07/24/2025
Rebecca Mashaw
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab significantly surpassed placebo for primary composite endpoints of clinical response at week 12 followed by either clinical remission or endoscopic response at week 48.
In both trials, guselkumab...
07/24/2025
Advances in Inflammatory Bowel Disease Network
News
Stricture-Related Resections Rising in Crohn’s Disease Despite Overall Decline in Surgical Rates
05/29/2025
Jessica Garlewicz
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess longitudinal trends in crohn's disease-related bowel surgeries, particularly for obstruction, following the introduction of infliximab in 1998.
The study aimed to assess...
05/29/2025
Advances in Inflammatory Bowel Disease Network
News
Early Response to Upadacitinib Predicts Long-Term Improvements in Crohn’s Disease
04/03/2025
Jessica Garlewicz
Patients with early response achieved higher rates of clinical remission and reductions in fatigue and impairment.
Patients with early response achieved higher rates of clinical remission and reductions in fatigue and impairment.
Patients with early response...
04/03/2025
Advances in Inflammatory Bowel Disease Network
News
MASLD Linked to Worse Clinical Outcomes in Hospitalized Crohn’s Disease Patients
04/03/2025
Jessica Garlewicz
A new study examined 792,409 hospitalizations for Crohn's disease, of which 26,229 (3.3%) involved patients with coexisting metabolic dysfunction-associated steatotic liver disease.
A new study examined 792,409 hospitalizations for Crohn's disease, of which 26,229 (3.3%) involved patients with coexisting metabolic dysfunction-associated steatotic liver disease.
A new study examined 792,409...
04/03/2025
Gastroenterology
News
VCE-Guided Treat-to-Target Strategy Reduces Flares in Crohn’s Disease Remission
04/01/2025
Jessica Garlewicz
The study highlights the utility of mucosal assessment in driving treatment optimization, even in asymptomatic patients.
The study highlights the utility of mucosal assessment in driving treatment optimization, even in asymptomatic patients.
The study highlights the utility...
04/01/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Combined Ultrasound and Calprotectin at 3 Months Predict Postoperative Recurrence in Crohn’s Disease
05/07/2026
Jessica Garlewicz
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive...
05/07/2026
Advances in Inflammatory Bowel Disease Network
News
Oral Icotrokinra Demonstrates Efficacy in Ulcerative Colitis Regardless of Prior Advanced Therapy Exposure
05/05/2026
Jessica Garlewicz
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Early “Top-Down” Therapy Reduces Long-Term Complications in Crohn’s Disease
05/05/2026
Jessica Garlewicz
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Upper GI Crohn’s Disease Remains Underrecognized, Lacks Standardized Guidance
04/02/2026
Jessica Garlewicz
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of...
04/02/2026
Advances in Inflammatory Bowel Disease Network
Research Summary
Advanced Therapy May Reduce Antibiotic Dependence in Chronic Pouchitis After IPAA
03/18/2026
Jessica Garlewicz
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support...
03/18/2026
Advances in Inflammatory Bowel Disease Network
Research Review
New Meta-Analysis Highlights Burden of MASLD Among IBD Patients
02/03/2026
Rebecca Mashaw
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from...
02/03/2026
Gastroenterology
News
Medicare Will Cover GLP-1s for Obesity Under Deal with Pharma
11/06/2025
Rebecca Mashaw
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said...
11/06/2025
Advances in Inflammatory Bowel Disease Network
FDA alert
FDA Alert
FDA Approves Updated Indication for Upadacitinib in IBD
10/14/2025
Rebecca Mashaw
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for...
10/14/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Concomitant Medications Do Not Alter Efficacy of Advanced Therapies in Ulcerative Colitis, Study Finds
09/18/2025
Jessica Garlewicz
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that...
09/18/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Persistent Prothrombotic State Observed in Patients With ASUC
09/04/2025
Rebecca Mashaw
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with...
09/04/2025
Advances in Inflammatory Bowel Disease Network

Latest Podcasts

IBD Drive time logo
Expert Insights
IBD Drive Time: Jennifer Seminerio, MD, on Advanced Combination Therapy
06/12/2026
Raymond Cross, MD; Jennifer Seminerio, MD
Drs Cross and Seminerio discuss advanced combination therapy, which involves use of more than one biologic or a biologic and an advanced small molecule, including trial results to date, types of combinations, safety considerations, and which...
Drs Cross and Seminerio discuss advanced combination therapy, which involves use of more than one biologic or a biologic and an advanced small molecule, including trial results to date, types of combinations, safety considerations, and which...
Drs Cross and Seminerio discuss...
06/12/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Jordan Axelrad, MD, on Communicating Risks to Patients With IBD
05/22/2026
Raymond Cross, MD; Jordan Axelrad, MD
Drs Raymond Cross and Jordan Axelrad provide guidance to clinicians about the best ways to put risks—both of uncontrolled IBD and of therapies—into perspective for patients.
Drs Raymond Cross and Jordan Axelrad provide guidance to clinicians about the best ways to put risks—both of uncontrolled IBD and of therapies—into perspective for patients.
Drs Raymond Cross and Jordan...
05/22/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Colleen Kelly, MD, on Obesity and IBD
04/20/2026
Raymond Cross, MD; Colleen Kelly, MD
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on...
04/20/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Jared Magee, MD, on Men's Health in IBD
04/07/2026
Raymond Cross, MD; Jared Magee, MD
Drs Raymond Cross and Jared Magee discuss some of the special concerns that affect men with inflammatory bowel disease, from cardiac concerns to sexual dysfunction and assessing for anal cancer.
Drs Raymond Cross and Jared Magee discuss some of the special concerns that affect men with inflammatory bowel disease, from cardiac concerns to sexual dysfunction and assessing for anal cancer.
Drs Raymond Cross and Jared...
04/07/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: The Best of ECCO 2026
03/25/2026
Raymond Cross, MD; Sara Horst, MD; Jordan Axelrad, MD
Host Raymond Cross, MD, is joined by Drs Sara Horst and Jordan Axelrad to review the findings of their picks for the best presentations from the European Crohn's and Colitis Organization meeting held earlier this year.
Host Raymond Cross, MD, is joined by Drs Sara Horst and Jordan Axelrad to review the findings of their picks for the best presentations from the European Crohn's and Colitis Organization meeting held earlier this year.
Host Raymond Cross, MD, is...
03/25/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Shirley Cohen-Mekelburg, MD on Self-Care for IBD Patients
03/17/2026
Shirley Cohen-Mekelburg; Raymond Cross, MD
Host Raymond Cross, MD, calls on Dr Shirley Mekelburg-Cohen to discuss the importance of self-care among patients with IBD, what self-care consists of, and how to help patients learn to partner with their clinicians in controlling their...
Host Raymond Cross, MD, calls on Dr Shirley Mekelburg-Cohen to discuss the importance of self-care among patients with IBD, what self-care consists of, and how to help patients learn to partner with their clinicians in controlling their...
Host Raymond Cross, MD, calls on...
03/17/2026
Advances in Inflammatory Bowel Disease Network
New IBD Logo
Expert Insights
IBD Drive Time: James Lewis, MD, on Dysplasia Surveillance in IBD
02/23/2026
Raymond Cross, MD; James D. Lewis, MD
Dr James Lewis from the University of Pennsylvania and host Dr Raymond Cross discuss the risk of colon cancer among patients with inflammatory bowel disease, the importance of appropriate surveillance, and special considerations for choosing...
Dr James Lewis from the University of Pennsylvania and host Dr Raymond Cross discuss the risk of colon cancer among patients with inflammatory bowel disease, the importance of appropriate surveillance, and special considerations for choosing...
Dr James Lewis from the...
02/23/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Raymond Cross, MD, on Ostomy Complications
01/13/2026
Raymond Cross, MD; Sara Horst, MD
In this episode of IBD Drive Time, Dr Raymond Cross switches seats and acts as the guest with Sara Horst, MD, as host, to discuss the complexities of ostomy complications.
In this episode of IBD Drive Time, Dr Raymond Cross switches seats and acts as the guest with Sara Horst, MD, as host, to discuss the complexities of ostomy complications.
In this episode of IBD Drive...
01/13/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Conference Coverage
IBD Drive Time: The Best of ACG With Dr Sara Horst
12/01/2025
Raymond Cross, MD; Sara Horst, MD
Dr Sara Horst joins IBD Drive Time host Dr Raymond Cross to review their choices for the best presentations from the American College of Gastroenterology annual meeting.
Dr Sara Horst joins IBD Drive Time host Dr Raymond Cross to review their choices for the best presentations from the American College of Gastroenterology annual meeting.
Dr Sara Horst joins IBD Drive...
12/01/2025
Advances in Inflammatory Bowel Disease Network
IBD Drive Time
Podcast
IBD Drive Time: Freddy Caldera, MD, on Vaccines for Patients With IBD
11/03/2025
Raymond Cross, MD; Freddy Caldera, DO
Freddy Caldera, DO, returns to talk to IBD Drive Time host Raymond Cross, MD, about the best current recommendations for patients with IBD in the midst of controversy and confusion.
Freddy Caldera, DO, returns to talk to IBD Drive Time host Raymond Cross, MD, about the best current recommendations for patients with IBD in the midst of controversy and confusion.
Freddy Caldera, DO, returns to...
11/03/2025
Advances in Inflammatory Bowel Disease Network

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