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SIBO and Crohn's Disease

Rebecca Mashaw
04/28/2023

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Research Review
Bowel Urgency Remains an Underrecognized but High-Burden Symptom in Crohn’s Disease
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A key theme of the narrative review is the disconnect between patients and healthcare providers regarding the importance of bowel urgency in Crohn's disease.
A key theme of the narrative review is the disconnect between patients and healthcare providers regarding the importance of bowel urgency in Crohn's disease.
A key theme of the narrative...
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Disease Control, Not Age at Diagnosis, Drives Pregnancy Outcomes in Crohn’s Disease
06/11/2026
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Investigators concluded that proactive disease management and continued use of effective therapies during pregnancy to control disease activity—not disease duration or age at diagnosis—is the primary determinant of neonatal outcomes in...
Investigators concluded that proactive disease management and continued use of effective therapies during pregnancy to control disease activity—not disease duration or age at diagnosis—is the primary determinant of neonatal outcomes in...
Investigators concluded that...
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Biologic Prophylaxis Reduces Postoperative Recurrence in Crohn’s Disease
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The effect of biologic therapy in reducing risks of recurrence following surgery for Crohn’s disease was observed across patient subgroups, suggesting broad benefit regardless of individual risk profile, researchers reported.
The effect of biologic therapy in reducing risks of recurrence following surgery for Crohn’s disease was observed across patient subgroups, suggesting broad benefit regardless of individual risk profile, researchers reported.
The effect of biologic therapy...
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Artificial Sweeteners and Emulsifier Metabolites Linked to Crohn’s Disease Activity
06/11/2026
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In the first human study to demonstrate distinct P-80 metabolism in patients with Crohn's disease, researchers found that "dietary sweeteners and P-80 metabolites showed significant correlations with disease activity.”
In the first human study to demonstrate distinct P-80 metabolism in patients with Crohn's disease, researchers found that "dietary sweeteners and P-80 metabolites showed significant correlations with disease activity.”
In the first human study to...
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Latest News

Research Highlights
Combined Ultrasound and Calprotectin at 3 Months Predict Postoperative Recurrence in Crohn’s Disease
05/07/2026
Jessica Garlewicz
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive predictive value suggest that patients meeting both thresholds are at high risk for early recurrence and may need closer monitoring.
High specificity and positive...
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Oral Icotrokinra Demonstrates Efficacy in Ulcerative Colitis Regardless of Prior Advanced Therapy Exposure
05/05/2026
Jessica Garlewicz
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were...
05/05/2026
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Early “Top-Down” Therapy Reduces Long-Term Complications in Crohn’s Disease
05/05/2026
Jessica Garlewicz
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and...
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Upper GI Crohn’s Disease Remains Underrecognized, Lacks Standardized Guidance
04/02/2026
Jessica Garlewicz
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of...
04/02/2026
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Research Summary
Advanced Therapy May Reduce Antibiotic Dependence in Chronic Pouchitis After IPAA
03/18/2026
Jessica Garlewicz
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support...
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New Meta-Analysis Highlights Burden of MASLD Among IBD Patients
02/03/2026
Rebecca Mashaw
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from...
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Medicare Will Cover GLP-1s for Obesity Under Deal with Pharma
11/06/2025
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Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said...
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FDA alert
FDA Alert
FDA Approves Updated Indication for Upadacitinib in IBD
10/14/2025
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The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for...
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Concomitant Medications Do Not Alter Efficacy of Advanced Therapies in Ulcerative Colitis, Study Finds
09/18/2025
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New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that...
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Persistent Prothrombotic State Observed in Patients With ASUC
09/04/2025
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New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with...
09/04/2025
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