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October 2013 - FRMC

Department
10/23/2013
The FDA approved Xtandi® (enzalutamide) in August 2012 to treat patients with metastatic castration-resistant prostate cancer who previously failed treatment with docetaxel. The oral drug, marketed by Astellas Pharma, Inc. and Medivation,...
The FDA approved Xtandi® (enzalutamide) in August 2012 to treat patients with metastatic castration-resistant prostate cancer who previously failed treatment with docetaxel. The oral drug, marketed by Astellas Pharma, Inc. and Medivation,...
The FDA approved Xtandi®...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
Patients with chronic non-cancer pain maintained reductions in pain for at least 6 months, according to a review of randomized, controlled trials, single-arm, open-label trials, open-label extension trials, and epidemiologic trials.
Patients with chronic non-cancer pain maintained reductions in pain for at least 6 months, according to a review of randomized, controlled trials, single-arm, open-label trials, open-label extension trials, and epidemiologic trials.
Patients with chronic non-cancer...
10/23/2013
First Report Managed Care
Department
10/23/2013
Tim Casey
Patients with chronic non-cancer pain and opioid-induced constipation who took lubiprostone did not have an affect on opioid-induced analgesia.
Patients with chronic non-cancer pain and opioid-induced constipation who took lubiprostone did not have an affect on opioid-induced analgesia.
Patients with chronic non-cancer...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
Peoople with cancer and controlled, persistent pain had statistically significant higher mean unadjusted all-cause pharmacy costs if they had breakthrough pain. 
Peoople with cancer and controlled, persistent pain had statistically significant higher mean unadjusted all-cause pharmacy costs if they had breakthrough pain. 
Peoople with cancer and...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
At the AAPM meeting, healthcare professionals discussed issues related to cancer-related pain during a satellite symposium titled Managing Breakthrough Pain Across the Provider Continuum. 
At the AAPM meeting, healthcare professionals discussed issues related to cancer-related pain during a satellite symposium titled Managing Breakthrough Pain Across the Provider Continuum. 
At the AAPM meeting, healthcare...
10/23/2013
First Report Managed Care
Conference Insider
10/23/2013
Tim Casey
Five years ago, David Fishbain, MD, and co-authors published an article in Pain Medicine that examined issues related to opioids.
Five years ago, David Fishbain, MD, and co-authors published an article in Pain Medicine that examined issues related to opioids.
Five years ago, David Fishbain,...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
To help clinicians treat patients with castrate-resistant prostate cancer, the AUA released guidelines at its annual meeting to decide what options are best for numerous sub-types of the disease. 
To help clinicians treat patients with castrate-resistant prostate cancer, the AUA released guidelines at its annual meeting to decide what options are best for numerous sub-types of the disease. 
To help clinicians treat...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
San Diego—An interim analysis of a prospective, randomized trial found that there was no significant difference in 90-day complications after patients with bladder cancer underwent robotic radical cystectomy with extracorporeal urinary...
San Diego—An interim analysis of a prospective, randomized trial found that there was no significant difference in 90-day complications after patients with bladder cancer underwent robotic radical cystectomy with extracorporeal urinary...
San Diego—An interim analysis of...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
San Diego—After 52 weeks of treatment, patients with type 2 diabetes who received 100 mg or 300 mg of canagliflozin had reductions in hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), body weight and systolic blood pressure, according to...
San Diego—After 52 weeks of treatment, patients with type 2 diabetes who received 100 mg or 300 mg of canagliflozin had reductions in hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), body weight and systolic blood pressure, according to...
San Diego—After 52 weeks of...
10/23/2013
First Report Managed Care
10/23/2013
Tim Casey
San Diego—Patients with type 2 diabetes and hypertension who received 10 mg or 25 mg of empagliflozin once daily for 12 weeks had significant and clinically meaningful reductions in systolic and diastolic blood pressure, according to a phase...
San Diego—Patients with type 2 diabetes and hypertension who received 10 mg or 25 mg of empagliflozin once daily for 12 weeks had significant and clinically meaningful reductions in systolic and diastolic blood pressure, according to a phase...
San Diego—Patients with type 2...
10/23/2013
First Report Managed Care
10/23/2013
Kevin L. Carter
Based on Adult Treatment Panel III guidelines, it is common current practice to suggest annual lipid testing in patients with coronary heart disease (CHD). Those with abnormal lipid levels are suggested to receive intensified treatment. For...
Based on Adult Treatment Panel III guidelines, it is common current practice to suggest annual lipid testing in patients with coronary heart disease (CHD). Those with abnormal lipid levels are suggested to receive intensified treatment. For...
Based on Adult Treatment Panel...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Jill Sederstorm
Population health in the United States has improved, but the improvements have not kept pace with other wealthy nations, according to a new study that assessed the state of United States health from 1990 to 2010. The study measured the burden...
Population health in the United States has improved, but the improvements have not kept pace with other wealthy nations, according to a new study that assessed the state of United States health from 1990 to 2010. The study measured the burden...
Population health in the United...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Tori Socha
One of the primary goals of the Patient Protection and Affordable Care Act (ACA) is to reduce the number of uninsured Americans. To achieve this, the act provides for affordable options for coverage including Medicaid and Health Insurance...
One of the primary goals of the Patient Protection and Affordable Care Act (ACA) is to reduce the number of uninsured Americans. To achieve this, the act provides for affordable options for coverage including Medicaid and Health Insurance...
One of the primary goals of the...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Jill Sederstorm
Integrated delivery systems (lDSs) have been shown to improve quality and lower costs in ambulatory care settings.
Integrated delivery systems (lDSs) have been shown to improve quality and lower costs in ambulatory care settings.
Integrated delivery systems...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
Percutaneous coronary intervention (PCI) is an effective treatment for patients with acute ST-segment elevation myocardial infarction (STEMI). PCI restores blood flow to the coronary artery that is deemed to be causing the myocardial...
Percutaneous coronary intervention (PCI) is an effective treatment for patients with acute ST-segment elevation myocardial infarction (STEMI). PCI restores blood flow to the coronary artery that is deemed to be causing the myocardial...
Percutaneous coronary...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Tori Socha
P2Y12 receptor antagonists are effective in patients with non–ST-segment elevation (NSTE) acute coronary syndromes. A loading dose of clopidogrel is required in patients undergoing percutaneous coronary intervention (PCI); however,...
P2Y12 receptor antagonists are effective in patients with non–ST-segment elevation (NSTE) acute coronary syndromes. A loading dose of clopidogrel is required in patients undergoing percutaneous coronary intervention (PCI); however,...
P2Y12 receptor antagonists are...
10/23/2013
First Report Managed Care
10/23/2013
Mary Beth Nierengarten
Results of a phase 3, randomized, open-label trial demonstrate the noninferiority in progression-free survival of pazopanib compared with sunitinib in patients with metastatic renal-cell carcinoma.
Results of a phase 3, randomized, open-label trial demonstrate the noninferiority in progression-free survival of pazopanib compared with sunitinib in patients with metastatic renal-cell carcinoma.
Results of a phase 3,...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
Hypertension, a major contributor to cardiovascular disease, affects 29% of the adult population in the United States (n=65 million). Effective therapies to control hypertension have been available for >50 years; however, from 2001 to...
Hypertension, a major contributor to cardiovascular disease, affects 29% of the adult population in the United States (n=65 million). Effective therapies to control hypertension have been available for >50 years; however, from 2001 to...
Hypertension, a major...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Kevin L. Carter
Vedolizumab, a humanized monoclonal antibody, selectively blocks gut lymphocyte trafficking without interfering with trafficking to the central nervous system.
Vedolizumab, a humanized monoclonal antibody, selectively blocks gut lymphocyte trafficking without interfering with trafficking to the central nervous system.
Vedolizumab, a humanized...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
The vast majority of patients with degenerative mitral regurgitation have symptoms improved and normal life expectancy restored with surgical intervention. In patients without American College of Cardiology (ACC)/American Heart Association...
The vast majority of patients with degenerative mitral regurgitation have symptoms improved and normal life expectancy restored with surgical intervention. In patients without American College of Cardiology (ACC)/American Heart Association...
The vast majority of patients...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
It has been well documented that overweight or obese patients with type 2 diabetes benefit from weight loss, with numerous short-term studies demonstrating such benefits as improved glycemic control, reduction of cardiovascular disease risk...
It has been well documented that overweight or obese patients with type 2 diabetes benefit from weight loss, with numerous short-term studies demonstrating such benefits as improved glycemic control, reduction of cardiovascular disease risk...
It has been well documented that...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
Patients with advanced prostate cancer are often treated with androgen deprivation therapy (ADT), a therapy that is also increasingly being used in patients with less severe disease. Studies have demonstrated that ADT provides beneficial...
Patients with advanced prostate cancer are often treated with androgen deprivation therapy (ADT), a therapy that is also increasingly being used in patients with less severe disease. Studies have demonstrated that ADT provides beneficial...
Patients with advanced prostate...
10/23/2013
First Report Managed Care
10/23/2013
Mary Mihalovic
In men with castration-resistant prostate cancer and bone metastases, the use of the targeted alpha emitter radium-223 dichloride showed enough improvement in overall survival to warrant the trial’s early discontinuation.
In men with castration-resistant prostate cancer and bone metastases, the use of the targeted alpha emitter radium-223 dichloride showed enough improvement in overall survival to warrant the trial’s early discontinuation.
In men with castration-resistant...
10/23/2013
First Report Managed Care
10/23/2013
Kevin L. Carter
There has been increased interest in developing tumor immunity as a treatment strategy for several types of cancer. Immune checkpoint blockade is one approach that has induced regressions in cancer. Ipilimumab, a fully human, IgG1 monoclonal...
There has been increased interest in developing tumor immunity as a treatment strategy for several types of cancer. Immune checkpoint blockade is one approach that has induced regressions in cancer. Ipilimumab, a fully human, IgG1 monoclonal...
There has been increased...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Eileen Koutnik-Fotopoulos
A fixed-dose regimen of apixaban, an oral factor Xa inhibitor, to treat venous thromboembolism (VTE) demonstrated noninferiority to conventional therapy with enoxaparin and warfarin, according to findings from the AMPLIFY (Apixaban for the...
A fixed-dose regimen of apixaban, an oral factor Xa inhibitor, to treat venous thromboembolism (VTE) demonstrated noninferiority to conventional therapy with enoxaparin and warfarin, according to findings from the AMPLIFY (Apixaban for the...
A fixed-dose regimen of...
10/23/2013
First Report Managed Care
10/23/2013
Tori Socha
Among Medicare beneficiaries, falls account for approximately 10% of emergency department visits and 6% of hospitalizations.
Among Medicare beneficiaries, falls account for approximately 10% of emergency department visits and 6% of hospitalizations.
Among Medicare beneficiaries,...
10/23/2013
First Report Managed Care
10/23/2013
Mary Beth Nierengarten
A recent trial shows that combining clopidogrel and aspirin is superior to aspirin alone for reducing the risk of stroke among patients with TIA.
A recent trial shows that combining clopidogrel and aspirin is superior to aspirin alone for reducing the risk of stroke among patients with TIA.
A recent trial shows that...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Tori Socha
Over the past 20 years, the use of computed tomography (CT) in pediatrics has been increasing. In 2001, 5% to 11% of the 85 million CT scans performed in the United States were on children. The use of CT has improved diagnostic capabilities,...
Over the past 20 years, the use of computed tomography (CT) in pediatrics has been increasing. In 2001, 5% to 11% of the 85 million CT scans performed in the United States were on children. The use of CT has improved diagnostic capabilities,...
Over the past 20 years, the use...
10/23/2013
First Report Managed Care
10/23/2013
Eileen Koutnik-Fotopoulos
The introduction of biologic tumor necrosis factor inhibitors has improved the treatment of early rheumatoid arthritis (RA), but at a significant cost. These medications have been shown to lead to superior radiological outcomes compared with...
The introduction of biologic tumor necrosis factor inhibitors has improved the treatment of early rheumatoid arthritis (RA), but at a significant cost. These medications have been shown to lead to superior radiological outcomes compared with...
The introduction of biologic...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Eileen Koutnik-Fotopoulos
A new report, Medicare: Action Needed to Address Higher Use of Anatomic Pathology Services by Providers Who Self-Refer, from the Government Accountability Office (GAO) found a dramatic increase in self-referred anatomic pathology services...
A new report, Medicare: Action Needed to Address Higher Use of Anatomic Pathology Services by Providers Who Self-Refer, from the Government Accountability Office (GAO) found a dramatic increase in self-referred anatomic pathology services...
A new report, Medicare: Action...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Tim Casey
Across the United States, reports have revealed the increasing epidemic of people abusing, misusing, and dying from opioids and other prescription pain medications. The trend has caused government officials, pharmaceutical companies, and...
Across the United States, reports have revealed the increasing epidemic of people abusing, misusing, and dying from opioids and other prescription pain medications. The trend has caused government officials, pharmaceutical companies, and...
Across the United States,...
10/23/2013
First Report Managed Care
News Connection
10/23/2013
Tim Casey
A few years ago, executives at Pepsi Bottling Ventures noticed many of the company’s employees were not visiting doctors on a regular basis. A large percentage of the workers drive trucks and deliver products to 22 bottling and distribution...
A few years ago, executives at Pepsi Bottling Ventures noticed many of the company’s employees were not visiting doctors on a regular basis. A large percentage of the workers drive trucks and deliver products to 22 bottling and distribution...
A few years ago, executives at...
10/23/2013
First Report Managed Care