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July 2012 - FRMC

07/22/2013
Tim Casey
  Chicago—Patients who took tamoxifen for 10 years had a reduced disease recurrence and breast cancer mortality compared with a group receiving the drug for 5 years, according to a randomized, phase 3 trial that began >20 years ago. The...
  Chicago—Patients who took tamoxifen for 10 years had a reduced disease recurrence and breast cancer mortality compared with a group receiving the drug for 5 years, according to a randomized, phase 3 trial that began >20 years ago. The...
  Chicago—Patients who took...
07/22/2013
First Report Managed Care
07/23/2012
Kevin L. Carter
Studies of animal models have found that proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, has a role in the post-translational regulation of LDL-receptor activity. PCSK9, which is synthesized primarily in the...
Studies of animal models have found that proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, has a role in the post-translational regulation of LDL-receptor activity. PCSK9, which is synthesized primarily in the...
Studies of animal models have...
07/23/2012
First Report Managed Care
News
07/23/2012
Kevin L. Carter
A series of somatic mutations that affect the progression and development of acute myeloid leukemia (AML) has recently been discovered. The prognostic relevance of cytogenetic abnormalities has led to the widespread adoption of risk...
A series of somatic mutations that affect the progression and development of acute myeloid leukemia (AML) has recently been discovered. The prognostic relevance of cytogenetic abnormalities has led to the widespread adoption of risk...
A series of somatic mutations...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—After 30 months, patients with Philadelphia chromosome-positive chronic phase chronic myeloid leukemia who took bosutinib had superior efficacy and safety results compared with those who received imatinib, according to updated...
Chicago—After 30 months, patients with Philadelphia chromosome-positive chronic phase chronic myeloid leukemia who took bosutinib had superior efficacy and safety results compared with those who received imatinib, according to updated...
Chicago—After 30 months,...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—A phase 3, international, randomized trial of patients with hormone-sensitive metastatic prostate cancer found that overall survival was inferior in those who had intermittent androgen deprivation therapy compared with those who...
Chicago—A phase 3, international, randomized trial of patients with hormone-sensitive metastatic prostate cancer found that overall survival was inferior in those who had intermittent androgen deprivation therapy compared with those who...
Chicago—A phase 3,...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—An analysis of an ongoing phase 2 study found that patients with nonmetastatic, castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA) reacted well to and managed toxicities when taking orteronel, an...
Chicago—An analysis of an ongoing phase 2 study found that patients with nonmetastatic, castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA) reacted well to and managed toxicities when taking orteronel, an...
Chicago—An analysis of an...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—The first phase 3 study to evaluate trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer found that the investigational antibody drug conjugate had superior efficacy and safety compared with an...
Chicago—The first phase 3 study to evaluate trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer found that the investigational antibody drug conjugate had superior efficacy and safety compared with an...
Chicago—The first phase 3 study...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—A phase 3 study found that nab-paclitaxel and ixabepilone were not superior to standard treatment (paclitaxel) in patients with chemotherapy-naïve metastatic breast cancer who also received bevacizumab. Hope S. Rugo, MD, professor of...
Chicago—A phase 3 study found that nab-paclitaxel and ixabepilone were not superior to standard treatment (paclitaxel) in patients with chemotherapy-naïve metastatic breast cancer who also received bevacizumab. Hope S. Rugo, MD, professor of...
Chicago—A phase 3 study found...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Chicago—Patients with advanced stage non–small cell lung cancer (NSCLC) who took the investigational oral agent afatinib had a significantly longer progression-free survival compared with those who received a standard combination chemotherapy...
Chicago—Patients with advanced stage non–small cell lung cancer (NSCLC) who took the investigational oral agent afatinib had a significantly longer progression-free survival compared with those who received a standard combination chemotherapy...
Chicago—Patients with advanced...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Orlando—When cancer patients undergo chemotherapy treatments, they face numerous challenges, among them nausea and vomiting. Physicians and nurses sometimes underestimate how many patients will have these side effects, according to Charles...
Orlando—When cancer patients undergo chemotherapy treatments, they face numerous challenges, among them nausea and vomiting. Physicians and nurses sometimes underestimate how many patients will have these side effects, according to Charles...
Orlando—When cancer patients...
07/23/2012
First Report Managed Care
Conference Insider
07/23/2012
Tim Casey
Orlando—Patients with acute coronary syndromes have several options when it comes to antiplatelet therapies, including aspirin, clopidogrel, prasugrel, and glycoprotein IIb/IIIa inhibitors such as abciximab, eptifibatide, and tirofiban. The...
Orlando—Patients with acute coronary syndromes have several options when it comes to antiplatelet therapies, including aspirin, clopidogrel, prasugrel, and glycoprotein IIb/IIIa inhibitors such as abciximab, eptifibatide, and tirofiban. The...
Orlando—Patients with acute...
07/23/2012
First Report Managed Care
07/23/2012
Jill Sederstorm
Healthcare-related spending continues to grow each year, making it a challenge for policymakers to find ways to ensure those costs are met, according to a new report from The Henry J. Kaiser Family Foundation. The report, titled Healthcare...
Healthcare-related spending continues to grow each year, making it a challenge for policymakers to find ways to ensure those costs are met, according to a new report from The Henry J. Kaiser Family Foundation. The report, titled Healthcare...
Healthcare-related spending...
07/23/2012
First Report Managed Care
07/23/2012
Jill Sederstorm
A robust healthcare reform initiative in the state of Massachusetts has significantly reduced the number of uninsured residents in the state and improved patient access to healthcare services, but there are still challenges that remain. These...
A robust healthcare reform initiative in the state of Massachusetts has significantly reduced the number of uninsured residents in the state and improved patient access to healthcare services, but there are still challenges that remain. These...
A robust healthcare reform...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
The centerpiece of the Medicare Modernization Act of 2003 was the Part D prescription drug benefit. The cost of the program has been approximately 30% lower than projected by the Congressional Budget Office (CBO) during the Congressional...
The centerpiece of the Medicare Modernization Act of 2003 was the Part D prescription drug benefit. The cost of the program has been approximately 30% lower than projected by the Congressional Budget Office (CBO) during the Congressional...
The centerpiece of the Medicare...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
As states look forward to FY 2013, economic conditions have, on the whole, shown improvement.
As states look forward to FY 2013, economic conditions have, on the whole, shown improvement.
As states look forward to FY...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
Recent data indicate that 16.2% of pregnant teens and 7.4% of pregnant women 18 to 25 years of age use illicit drugs.
Recent data indicate that 16.2% of pregnant teens and 7.4% of pregnant women 18 to 25 years of age use illicit drugs.
Recent data indicate that 16.2%...
07/23/2012
First Report Managed Care
07/23/2012
Jill Sederstorm
A study of youth with type 2 diabetes found that combination treatment with metformin and rosiglitazone was superior to metformin alone in providing durable glycemic control. The results of the TODAY (Treatment Options for Type 2 Diabetes in...
A study of youth with type 2 diabetes found that combination treatment with metformin and rosiglitazone was superior to metformin alone in providing durable glycemic control. The results of the TODAY (Treatment Options for Type 2 Diabetes in...
A study of youth with type 2...
07/23/2012
First Report Managed Care
07/23/2012
Mary Beth Nierengarten
Results of a retrospective population-based cohort study [JAMA. 2012;307(17):1827-1837] show that older women with breast cancer treated with brachytherapy compared with whole-breast irradiation (WBI) have worse outcomes in terms of less...
Results of a retrospective population-based cohort study [JAMA. 2012;307(17):1827-1837] show that older women with breast cancer treated with brachytherapy compared with whole-breast irradiation (WBI) have worse outcomes in terms of less...
Results of a retrospective...
07/23/2012
First Report Managed Care
07/23/2012
Jill Sederstorm
A randomized study of patients with chronic ischemic heart failure revealed that patients who received transendocardial injections of autologous bone marrow mononuclear cells (BMCs) did not demonstrate improved left ventricular end-systolic...
A randomized study of patients with chronic ischemic heart failure revealed that patients who received transendocardial injections of autologous bone marrow mononuclear cells (BMCs) did not demonstrate improved left ventricular end-systolic...
A randomized study of patients...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
Obesity is a serious condition that is associated with numerous comorbid conditions, including heart disease, bone and joint problems, diabetes, and elevated cholesterol levels. The 2009 Medical Expenditure Panel Survey (MEPS) includes data...
Obesity is a serious condition that is associated with numerous comorbid conditions, including heart disease, bone and joint problems, diabetes, and elevated cholesterol levels. The 2009 Medical Expenditure Panel Survey (MEPS) includes data...
Obesity is a serious condition...
07/23/2012
First Report Managed Care
News
07/23/2012
Mary Mihalovic
Laquinimod, an oral quinolone-3-carboxamide, was shown to slow the progression of disability and reduce rates of relapse in patients with relapsing-remitting multiple sclerosis (RRMS), according to results of a recent phase 3 study [N Engl J...
Laquinimod, an oral quinolone-3-carboxamide, was shown to slow the progression of disability and reduce rates of relapse in patients with relapsing-remitting multiple sclerosis (RRMS), according to results of a recent phase 3 study [N Engl J...
Laquinimod, an oral...
07/23/2012
First Report Managed Care
07/23/2012
Kevin L. Carter
According to the Department of Veterans Affairs, PTSD is the most prevalent mental health disorder among veterans of these conflicts who use VA healthcare benefits.
According to the Department of Veterans Affairs, PTSD is the most prevalent mental health disorder among veterans of these conflicts who use VA healthcare benefits.
According to the Department of...
07/23/2012
Veterans Health Today
07/23/2012
Jill Sederstorm
Transcatheter aortic-valve replacement (TAVR) was found to reduce rates of death and hospitalization in patients with severe aortic stenosis who were not suitable candidates for surgery after 2 years of follow-up when compared with patients...
Transcatheter aortic-valve replacement (TAVR) was found to reduce rates of death and hospitalization in patients with severe aortic stenosis who were not suitable candidates for surgery after 2 years of follow-up when compared with patients...
Transcatheter aortic-valve...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
Containing medication costs by shifting costs to patients is a strategy being increasingly utilized used by private health insurance plans. Studies have shown that when patients bear a greater proportion of medication costs, medication...
Containing medication costs by shifting costs to patients is a strategy being increasingly utilized used by private health insurance plans. Studies have shown that when patients bear a greater proportion of medication costs, medication...
Containing medication costs by...
07/23/2012
First Report Managed Care
07/23/2012
Tori Socha
For patients with extensive coronary artery disease, mortality can be reduced through coronary-artery bypass grafting (CABG), a procedure generally performed using cardiopulmonary bypass (on-pump). Use of the on-pump approach results in...
For patients with extensive coronary artery disease, mortality can be reduced through coronary-artery bypass grafting (CABG), a procedure generally performed using cardiopulmonary bypass (on-pump). Use of the on-pump approach results in...
For patients with extensive...
07/23/2012
First Report Managed Care
07/23/2012
Kevin L. Carter
Although thrombolytic treatment with alteplase, a recombinant tissue plasminogen activator, is the accepted therapy for ischemic stroke, alteplase has been proven to be far from ideal. Tenecteplase, a genetically engineered mutant tissue...
Although thrombolytic treatment with alteplase, a recombinant tissue plasminogen activator, is the accepted therapy for ischemic stroke, alteplase has been proven to be far from ideal. Tenecteplase, a genetically engineered mutant tissue...
Although thrombolytic treatment...
07/23/2012
First Report Managed Care
07/23/2012
Kristina Woodworth
An analysis of data from the National Health and Nutrition Examination Survey (NHANES) has concluded that smoking, blood pressure, blood glucose level, diet, and physical activity are all closely linked with all-cause, cardiovascular disease...
An analysis of data from the National Health and Nutrition Examination Survey (NHANES) has concluded that smoking, blood pressure, blood glucose level, diet, and physical activity are all closely linked with all-cause, cardiovascular disease...
An analysis of data from the...
07/23/2012
First Report Managed Care
07/23/2012
Kevin L. Carter
Although epinephrine is often used in cardiopulmonary resuscitation for out-of-hospital cardiac arrest, the effectiveness of use before hospital arrival is unknown.
Although epinephrine is often used in cardiopulmonary resuscitation for out-of-hospital cardiac arrest, the effectiveness of use before hospital arrival is unknown.
Although epinephrine is often...
07/23/2012
First Report Managed Care
07/23/2012
Eileen Koutnik-Fotopoulos
During a 6-year period, utilization of anesthesia services for gastroenterology procedures increased significantly, particularly in low-risk patients who may have been candidates for less expensive intravenous sedation [JAMA....
During a 6-year period, utilization of anesthesia services for gastroenterology procedures increased significantly, particularly in low-risk patients who may have been candidates for less expensive intravenous sedation [JAMA....
During a 6-year period,...
07/23/2012
First Report Managed Care
Conference Insider
07/23/2012
Mary Mihalovic
The use of flexible sigmoidoscopy as a screening tool significantly reduced the overall mortality associated with colorectal cancer by 26% and its incidence by 21%, according to results of a recent study [N Engl J Med. 2012;...
The use of flexible sigmoidoscopy as a screening tool significantly reduced the overall mortality associated with colorectal cancer by 26% and its incidence by 21%, according to results of a recent study [N Engl J Med. 2012;...
The use of flexible...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
Like her colleagues throughout the world, Margaret Hamburg, MD, has been dealing with issues that she could have never foreseen when she became the FDA’s commissioner in May 2009. Science continues to advance rapidly, making it difficult to...
Like her colleagues throughout the world, Margaret Hamburg, MD, has been dealing with issues that she could have never foreseen when she became the FDA’s commissioner in May 2009. Science continues to advance rapidly, making it difficult to...
Like her colleagues throughout...
07/23/2012
First Report Managed Care
07/23/2012
Tim Casey
At 10:22 am EDT on June 28, 866,000 people logged onto SCOTUSblog, a website devoted to providing up-to-the minute coverage of Supreme Court decisions. Minutes earlier, the Supreme Court had upheld the constitutionality of the Patient...
At 10:22 am EDT on June 28, 866,000 people logged onto SCOTUSblog, a website devoted to providing up-to-the minute coverage of Supreme Court decisions. Minutes earlier, the Supreme Court had upheld the constitutionality of the Patient...
At 10:22 am EDT on June 28,...
07/23/2012
First Report Managed Care