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January 2013 - FRMC

Adjustments to Inhaled Corticosteroids in Asthma
01/22/2013
Kristina Woodworth
A study in adults with mild-to-moderate persistent asthma controlled with low-dose inhaled corticosteroid therapy has demonstrated that adjustments in therapy based on biomarkers or symptoms were no better than standard physician...
A study in adults with mild-to-moderate persistent asthma controlled with low-dose inhaled corticosteroid therapy has demonstrated that adjustments in therapy based on biomarkers or symptoms were no better than standard physician...
A study in adults with...
01/22/2013
First Report Managed Care
News Connection
Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors
01/22/2013
Kevin L. Carter
Over the years, sources of grafts in allogeneic hematopoietic stem-cell transplantation have evolved from bone marrow to filgrastim-stimulated peripheral blood, which has a much higher content of blood progenitor cells. Several large,...
Over the years, sources of grafts in allogeneic hematopoietic stem-cell transplantation have evolved from bone marrow to filgrastim-stimulated peripheral blood, which has a much higher content of blood progenitor cells. Several large,...
Over the years, sources of...
01/22/2013
First Report Managed Care
Pomalidomide in Multiple Myeloma Patients
01/22/2013
Tim Casey
Atlanta—Patients with multiple myeloma who had primary refractory or relapsed and refractory disease had a significant improvement in progression-free and overall survival if they took pomalidomide plus low-dose dexamethasone compared with a...
Atlanta—Patients with multiple myeloma who had primary refractory or relapsed and refractory disease had a significant improvement in progression-free and overall survival if they took pomalidomide plus low-dose dexamethasone compared with a...
Atlanta—Patients with multiple...
01/22/2013
First Report Managed Care
Bendamustine and Rituximab to Treat Mantle Cell Lymphoma
01/22/2013
Tim Casey
Atlanta—A phase 2, single-arm, multicenter study found that patients with mantle cell lymphoma who had received up to 3 prior courses of chemotherapy had an overall response rate of 82% to the combination treatment of bendamustine plus...
Atlanta—A phase 2, single-arm, multicenter study found that patients with mantle cell lymphoma who had received up to 3 prior courses of chemotherapy had an overall response rate of 82% to the combination treatment of bendamustine plus...
Atlanta—A phase 2, single-arm,...
01/22/2013
First Report Managed Care
Lenalidomide for Mantle Cell Lymphoma
01/22/2013
Tim Casey
Atlanta—Patients with mantle cell lymphoma who took lenalidomide had a 35% overall response rate to the drug and median progression-free survival of 8.8 months, according to a subset analysis of a phase 2, single-arm, open-label,...
Atlanta—Patients with mantle cell lymphoma who took lenalidomide had a 35% overall response rate to the drug and median progression-free survival of 8.8 months, according to a subset analysis of a phase 2, single-arm, open-label,...
Atlanta—Patients with mantle...
01/22/2013
First Report Managed Care
Ruxolitinib and Erythropoiesis-Stimulating Agents for Myelofibrosis
01/22/2013
Tim Casey
Atlanta—A posthoc analysis of a phase 3 study found that patients with myelofibrosis who were receiving erythropoiesis-stimulating agents (ESAs) tolerated the concomitant use of ruxolitinib, a potent janus kinase 1 and 2 inhibitor. The...
Atlanta—A posthoc analysis of a phase 3 study found that patients with myelofibrosis who were receiving erythropoiesis-stimulating agents (ESAs) tolerated the concomitant use of ruxolitinib, a potent janus kinase 1 and 2 inhibitor. The...
Atlanta—A posthoc analysis of a...
01/22/2013
First Report Managed Care
Dabigatran Etexilate and Knee or Hip Replacement Surgery
01/22/2013
Tim Casey
A study found that dabigatran etexilate was effective and well tolerated in patients undergoing total knee or hip replacement surgery.
A study found that dabigatran etexilate was effective and well tolerated in patients undergoing total knee or hip replacement surgery.
A study found that dabigatran...
01/22/2013
First Report Managed Care
AMG 145 Lowers LDL-C in Statin-Intolerant Patients
01/22/2013
Tim Casey
Los Angeles—Patients with high cholesterol who cannot tolerate statins achieved reductions in low-density lipoprotein cholesterol (LDL-C) after taking AMG 145, an investigational drug, according to a global, phase 2, randomized, double-blind,...
Los Angeles—Patients with high cholesterol who cannot tolerate statins achieved reductions in low-density lipoprotein cholesterol (LDL-C) after taking AMG 145, an investigational drug, according to a global, phase 2, randomized, double-blind,...
Los Angeles—Patients with high...
01/22/2013
First Report Managed Care
Daily Intake of Multivitamin Does Not Reduce Risk of Cardiovascular Disease
01/22/2013
Tim Casey
Los Angeles—Male physicians who took a multivitamin every day for more than a decade had similar rates of major cardiovascular events, total myocardial infarction, and total stroke compared with a group that took a placebo, according to a...
Los Angeles—Male physicians who took a multivitamin every day for more than a decade had similar rates of major cardiovascular events, total myocardial infarction, and total stroke compared with a group that took a placebo, according to a...
Los Angeles—Male physicians who...
01/22/2013
First Report Managed Care
Conference Insider
Costs Associated with Acute Coronary Syndrome
01/22/2013
Tim Casey
Los Angeles—A retrospective database analysis of >37,000 claims from employees and their dependents found that patients with acute coronary syndrome (ACS) had high short-term and long-term disability and related costs that are higher or...
Los Angeles—A retrospective database analysis of >37,000 claims from employees and their dependents found that patients with acute coronary syndrome (ACS) had high short-term and long-term disability and related costs that are higher or...
Los Angeles—A retrospective...
01/22/2013
First Report Managed Care
Serelaxin Effective in Patients with Acute Heart Failure
01/22/2013
Tim Casey
Los Angeles—Patients with acute heart failure who took serelaxin intravenously for 48 hours had an improvement in dyspnea relief, in-hospital signs and symptoms of acute heart failure, in-hospital worsening of heart failure, and 180-day...
Los Angeles—Patients with acute heart failure who took serelaxin intravenously for 48 hours had an improvement in dyspnea relief, in-hospital signs and symptoms of acute heart failure, in-hospital worsening of heart failure, and 180-day...
Los Angeles—Patients with acute...
01/22/2013
First Report Managed Care
Higher Costs for Hospitals without Onsite Cardiac Surgery
01/22/2013
Tim Casey
Los Angeles—Nine months after undergoing an angioplasty procedure, patients who received percutaneous coronary intervention (PCI) at sites with onsite cardiac surgery had greater resource use, more hospital admissions, longer lengths of...
Los Angeles—Nine months after undergoing an angioplasty procedure, patients who received percutaneous coronary intervention (PCI) at sites with onsite cardiac surgery had greater resource use, more hospital admissions, longer lengths of...
Los Angeles—Nine months after...
01/22/2013
First Report Managed Care
Nationwide Kaiser Survey on Medicaid
01/22/2013
Tori Socha
Due to the enactment of the Patient Protection and Affordable Care Act (ACA), states are currently preparing for changes in Medicaid programs. In the original bill, the ACA would expand Medicaid eligibility to include eligibility for all...
Due to the enactment of the Patient Protection and Affordable Care Act (ACA), states are currently preparing for changes in Medicaid programs. In the original bill, the ACA would expand Medicaid eligibility to include eligibility for all...
Due to the enactment of the...
01/22/2013
First Report Managed Care
Recommended Preventive Services Covered by Medicaid
01/22/2013
Tori Socha
The 62 million Americans who are Medicaid beneficiaries tend to have lower incomes and greater health needs compared with those who have private health insurance. Reducing the risk of developing chronic conditions relies on preventive...
The 62 million Americans who are Medicaid beneficiaries tend to have lower incomes and greater health needs compared with those who have private health insurance. Reducing the risk of developing chronic conditions relies on preventive...
The 62 million Americans who are...
01/22/2013
First Report Managed Care
Variation in Healthcare Spending: Regional and Local
01/22/2013
Tori Socha
There is wide geographic variation in healthcare spending.
There is wide geographic variation in healthcare spending.
There is wide geographic...
01/22/2013
First Report Managed Care
Zoledronic Acid for Men with Osteoporosis
01/22/2013
Tori Socha
Osteoporosis is associated with morbidity and mortality in men; worldwide, among individuals >50 years of age, approximately 40% of all osteoporotic fractures occur in men, and mortality following osteoporotic fracture is higher in men...
Osteoporosis is associated with morbidity and mortality in men; worldwide, among individuals >50 years of age, approximately 40% of all osteoporotic fractures occur in men, and mortality following osteoporotic fracture is higher in men...
Osteoporosis is associated with...
01/22/2013
First Report Managed Care
Androgen Deprivation for Rising PSA Level
01/22/2013
Tori Socha
Following the discovery in 1941 that prostate cancer is dependent on androgen, the mainstay treatment for metastatic disease has been androgen deprivation. Since then, indications for androgen deprivation have been expanded to include...
Following the discovery in 1941 that prostate cancer is dependent on androgen, the mainstay treatment for metastatic disease has been androgen deprivation. Since then, indications for androgen deprivation have been expanded to include...
Following the discovery in 1941...
01/22/2013
First Report Managed Care
High-Sensitivity Cardiac Troponin T and Acute MI Diagnosis
01/22/2013
Tori Socha
Approximately 10% of all emergency department (ED) consultations concern patients with symptoms suggestive of acute myocardial infarction (AMI). The primary method of diagnosis of AMI involves utilization of electrocardiography (ECG) and...
Approximately 10% of all emergency department (ED) consultations concern patients with symptoms suggestive of acute myocardial infarction (AMI). The primary method of diagnosis of AMI involves utilization of electrocardiography (ECG) and...
Approximately 10% of all...
01/22/2013
First Report Managed Care
Aspirin to Prevent Recurrent Thromboembolism
01/22/2013
Tori Socha
Anticoagulant therapy is commonly recommended for patients who have had an initial episode of unprovoked venous thromboembolism. Once that therapy is discontinued, patients are at high risk for recurrence.
Anticoagulant therapy is commonly recommended for patients who have had an initial episode of unprovoked venous thromboembolism. Once that therapy is discontinued, patients are at high risk for recurrence.
Anticoagulant therapy is...
01/22/2013
First Report Managed Care
Ustekinumab Induction as Therapy for Crohn’s Disease
01/22/2013
Tori Socha
Crohn’s disease is a chronic inflammatory disease of the bowel. One third of patients with Crohn’s disease do not respond to initial treatment with tumor necrosis factor (TNF) antagonists; another one third have a transient response and...
Crohn’s disease is a chronic inflammatory disease of the bowel. One third of patients with Crohn’s disease do not respond to initial treatment with tumor necrosis factor (TNF) antagonists; another one third have a transient response and...
Crohn’s disease is a chronic...
01/22/2013
First Report Managed Care
News Connection
Dalcetrapib for Patients with a Recent Acute Coronary Syndrome
01/22/2013
Tori Socha
Observational studies have shown an inverse association between levels of high-density lipoprotein (HDL) cholesterol and incident events of coronary heart disease. The association persists in the majority of post hoc analyses and...
Observational studies have shown an inverse association between levels of high-density lipoprotein (HDL) cholesterol and incident events of coronary heart disease. The association persists in the majority of post hoc analyses and...
Observational studies have shown...
01/22/2013
First Report Managed Care
Patterns of Admission to the ICU in the VA Health System
01/22/2013
Tori Socha
The costs of critical care in the United States account for nearly 1% of the gross domestic product and nearly 15% of all hospital costs. There are wide variations in the use of critical care resources and, according to researchers, “better...
The costs of critical care in the United States account for nearly 1% of the gross domestic product and nearly 15% of all hospital costs. There are wide variations in the use of critical care resources and, according to researchers, “better...
The costs of critical care in...
01/22/2013
First Report Managed Care
News Connection
Discontinuation of Risperidone and Risk of Relapse in Alzheimer’s Disease
01/22/2013
Tori Socha
Patients with Alzheimer’s disease (AD) often exhibit symptoms of psychosis or agitation. These symptoms are associated with patient distress, and increased caregiver burden, cognitive decline, risk of institutionalization, and healthcare...
Patients with Alzheimer’s disease (AD) often exhibit symptoms of psychosis or agitation. These symptoms are associated with patient distress, and increased caregiver burden, cognitive decline, risk of institutionalization, and healthcare...
Patients with Alzheimer’s...
01/22/2013
First Report Managed Care
News Connection
Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease
01/22/2013
Kevin L. Carter
The prevalence of both atrial fibrillation and chronic kidney disease increases with age. The prevalence of atrial fibrillation is 2.3% among persons 40 years of age or older and 5.9% among those 65 years of age or older, and the prevalence...
The prevalence of both atrial fibrillation and chronic kidney disease increases with age. The prevalence of atrial fibrillation is 2.3% among persons 40 years of age or older and 5.9% among those 65 years of age or older, and the prevalence...
The prevalence of both atrial...
01/22/2013
First Report Managed Care
News Connection
Medicaid Expansion and Federal Spending
01/22/2013
Jill Sederstorm
States who choose to expand Medicaid eligibility under the Patient Protection and Affordability Care Act (ACA) will likely see large increases in coverage and federal spending, while seeing only small increases in state spending, according to...
States who choose to expand Medicaid eligibility under the Patient Protection and Affordability Care Act (ACA) will likely see large increases in coverage and federal spending, while seeing only small increases in state spending, according to...
States who choose to expand...
01/22/2013
First Report Managed Care
Uncertainty about ACA Fades
01/22/2013
Tim Casey
At the beginning of 2012, the future of the Patient Protection and Affordable Care Act (ACA) seemed uncertain. More than a dozen states had sued to have the healthcare reform law overturned and Republican presidential candidates vowed to...
At the beginning of 2012, the future of the Patient Protection and Affordable Care Act (ACA) seemed uncertain. More than a dozen states had sued to have the healthcare reform law overturned and Republican presidential candidates vowed to...
At the beginning of 2012, the...
01/22/2013
First Report Managed Care
States Prepare for Health Insurance Exchanges
01/22/2013
Tim Casey
During December, Kevin Counihan visited 7 cities in Connecticut, hosting sessions open to the public focused on explaining the state’s upcoming health insurance exchange. He delivered a speech and fielded questions in towns that have a large...
During December, Kevin Counihan visited 7 cities in Connecticut, hosting sessions open to the public focused on explaining the state’s upcoming health insurance exchange. He delivered a speech and fielded questions in towns that have a large...
During December, Kevin Counihan...
01/22/2013
First Report Managed Care

Behind the Bill

Behind the Bill
The Senate’s $3 Trillion Deal. Tax Relief Now, Medicaid Coverage Loss Later?
07/02/2025
Katie Hayes, MJ
The Senate has done it. After weeks of behind-the-scenes wrangling and last-minute amendments, lawmakers have passed a sprawling tax-and-spending megabill that makes good on a long-standing Republican goal: making the 2017 Trump tax cuts...
The Senate has done it. After weeks of behind-the-scenes wrangling and last-minute amendments, lawmakers have passed a sprawling tax-and-spending megabill that makes good on a long-standing Republican goal: making the 2017 Trump tax cuts...
The Senate has done it. After...
07/02/2025
First Report Managed Care
Behind the Bill
When a Cap Isn’t Just a Cap: How a Provider Tax Proposal Could Reshape Medicaid Financing
06/25/2025
Katie Hayes, MJ
In Washington, the most consequential policies are often buried in the fine print. One such detail in the Senate Finance Committee’s latest tax and spending proposal would gradually cap provider taxes—a core funding tool states use to pull in...
In Washington, the most consequential policies are often buried in the fine print. One such detail in the Senate Finance Committee’s latest tax and spending proposal would gradually cap provider taxes—a core funding tool states use to pull in...
In Washington, the most...
06/25/2025
First Report Managed Care
Behind the Bill
Rewriting the Safety Net? Inside the Senate’s Changes to Medicaid and the ACA
06/18/2025
Katie Hayes, MJ
Over the past few weeks, I’ve been following the progress of the One Big Beautiful Bill Act (OBBBA), which started in the House with sweeping tax reforms and some eye-catching health care proposals. Now, the Senate has released its (highly...
Over the past few weeks, I’ve been following the progress of the One Big Beautiful Bill Act (OBBBA), which started in the House with sweeping tax reforms and some eye-catching health care proposals. Now, the Senate has released its (highly...
Over the past few weeks, I’ve...
06/18/2025
First Report Managed Care
Behind the Bill
How States Might Respond to the One Big Beautiful Bill Act
06/11/2025
Katie Hayes, MJ
With the One Big Beautiful Bill Act (OBBBA) still in the hands of the Senate, much of the national conversation has centered on what this legislation would do to federal coverage programs. But regardless of how the federal process unfolds,...
With the One Big Beautiful Bill Act (OBBBA) still in the hands of the Senate, much of the national conversation has centered on what this legislation would do to federal coverage programs. But regardless of how the federal process unfolds,...
With the One Big Beautiful Bill...
06/11/2025
First Report Managed Care
Behind the Bill
Is the Affordable Care Act on the Chopping Block? What the One Big Beautiful Bill Act Tells Us.
06/04/2025
Katie Hayes, MJ
It’s been weeks of headline-grabbing debate over Medicaid work requirements, and the “One Big Beautiful Bill Act” remains in the Senate as they deliberate over several health care provisions. While the Medicaid provisions sparked most of the...
It’s been weeks of headline-grabbing debate over Medicaid work requirements, and the “One Big Beautiful Bill Act” remains in the Senate as they deliberate over several health care provisions. While the Medicaid provisions sparked most of the...
It’s been weeks of...
06/04/2025
First Report Managed Care
Behind the Bill
From House to Senate: The Journey of Cutting Medicaid
05/28/2025
Katie Hayes, MJ
Last week, the House of Representatives narrowly passed the One Big Beautiful Bill Act (HR 1, 119th Congress) by a single vote, sending the sweeping tax and spending reconciliation package, backed by President Trump, to the Senate. With its...
Last week, the House of Representatives narrowly passed the One Big Beautiful Bill Act (HR 1, 119th Congress) by a single vote, sending the sweeping tax and spending reconciliation package, backed by President Trump, to the Senate. With its...
Last week, the House of...
05/28/2025
First Report Managed Care
Behind the Bill
Eligibility, Paperwork, and Penalties: The Not-So-Hidden Costs of Medicaid ‘Reform’
05/21/2025
Katie Hayes, MJ
It’s been another eventful week in health policy—a phrase that’s quickly becoming routine. This time, House Republicans advanced a sweeping budget reconciliation bill, designed to implement elements of the March budget resolution, with a...
It’s been another eventful week in health policy—a phrase that’s quickly becoming routine. This time, House Republicans advanced a sweeping budget reconciliation bill, designed to implement elements of the March budget resolution, with a...
It’s been another eventful week...
05/21/2025
First Report Managed Care
Behind the Bill
A Busy Week in Drug Pricing Policy: Aligning US Drug Prices With Global Standards?
05/14/2025
Katie Hayes, MJ
It’s been a busy few days for drug pricing policy. While I’d love to dig into the details of both President Trump’s latest executive order and the newest Republican bill that would cut Medicaid spending, we don’t have the time—and this isn’t...
It’s been a busy few days for drug pricing policy. While I’d love to dig into the details of both President Trump’s latest executive order and the newest Republican bill that would cut Medicaid spending, we don’t have the time—and this isn’t...
It’s been a busy few days for...
05/14/2025
First Report Managed Care
BEHIND THE BILL
When Agencies Lose Power: How 3 Seismic Shifts are Transforming Pharmaceutical Regulation
05/07/2025
Katie Hayes, MJ
In the span of just 9 months, the landscape of administrative law has undergone a transformation so profound that pharmaceutical executives, health care providers, and patients alike are struggling to navigate the new terrain. The Supreme...
In the span of just 9 months, the landscape of administrative law has undergone a transformation so profound that pharmaceutical executives, health care providers, and patients alike are struggling to navigate the new terrain. The Supreme...
In the span of just 9 months,...
05/07/2025
First Report Managed Care
Behind the Bill
The Medicare Paradox, Part 3: Strategic Trade Doesn’t Have to be a Zero-Sum Game
05/07/2025
Katie Hayes, MJ
Over the past 2 weeks, I’ve examined the growing friction between the Section 232 pharmaceutical tariff investigations and the Medicare drug pricing reforms authorized by the Inflation Reduction Act (IRA). These 2 policy agendas—industrial...
Over the past 2 weeks, I’ve examined the growing friction between the Section 232 pharmaceutical tariff investigations and the Medicare drug pricing reforms authorized by the Inflation Reduction Act (IRA). These 2 policy agendas—industrial...
Over the past 2 weeks, I’ve...
05/07/2025
First Report Managed Care

Trending Articles

News
Comparative Effectiveness for Bronchodilator Responsiveness Testing
02/09/2024
Emry Lloyd
A new study compares the efficacy of salbutamol administration via a nebulizer vs a metered-dose inhaler with a spacer for bronchodilator responsiveness testing.
A new study compares the efficacy of salbutamol administration via a nebulizer vs a metered-dose inhaler with a spacer for bronchodilator responsiveness testing.
A new study compares the...
02/09/2024
First Report Managed Care
News
Trial to Test CAR T-Cell Therapy for Refractory Progressive MS
03/18/2024
Jolynn Tumolo
An autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate recently received clearance from the US Food and Drug Administration (FDA) as an investigational new drug for the treatment of patients with refractory...
An autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate recently received clearance from the US Food and Drug Administration (FDA) as an investigational new drug for the treatment of patients with refractory...
An autologous, fully human CD19...
03/18/2024
First Report Managed Care
Conference Coverage
PBM Legislation: Navigating Congressional Delays and Encouraging Progress
04/17/2024
Hannah Musick
Explore the world of federal pharmacy benefit manager (PBM) legislation and its potential impact on stakeholders in this in-depth analysis presented by Ross Margulies, JD, MPH, Partner and Co-Chair Healthcare and Life Sciences Coverage &...
Explore the world of federal pharmacy benefit manager (PBM) legislation and its potential impact on stakeholders in this in-depth analysis presented by Ross Margulies, JD, MPH, Partner and Co-Chair Healthcare and Life Sciences Coverage &...
Explore the world of federal...
04/17/2024
First Report Managed Care
Conference Coverage
The Impact of Fatigue on Prospective Memory in Persons With MS
05/23/2024
Hannah Musick
High fatigue levels in persons with multiple sclerosis (MS) are significantly associated with subjective impairment in prospective memory, particularly in tasks such as forgetting the date and missing appointments.
High fatigue levels in persons with multiple sclerosis (MS) are significantly associated with subjective impairment in prospective memory, particularly in tasks such as forgetting the date and missing appointments.
High fatigue levels in persons...
05/23/2024
First Report Managed Care
Interview
Enhancing Patient Services: Payer and Provider Considerations
06/28/2024
Patient services emerged as a central topic at AXS24, with many stakeholders emphasizing the need for consistency and accessibility in patient support. They also highlighted the importance of addressing both financial and emotional support...
Patient services emerged as a central topic at AXS24, with many stakeholders emphasizing the need for consistency and accessibility in patient support. They also highlighted the importance of addressing both financial and emotional support...
Patient services emerged as a...
06/28/2024
First Report Managed Care

January 2013 Volume 10 Issue 1

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