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August 2012 - FRMC

08/14/2013
Tori Socha
Strategies suggested to curb increasing healthcare costs in the United States often focus on physicians, calling for reductions in waste and increased conservative stewardship of resources. Noting the importance of physicians’ perspectives on...
Strategies suggested to curb increasing healthcare costs in the United States often focus on physicians, calling for reductions in waste and increased conservative stewardship of resources. Noting the importance of physicians’ perspectives on...
Strategies suggested to curb...
08/14/2013
First Report Managed Care
08/16/2012
Kevin L. Carter
Until recently, there was no systemic therapy shown to improve overall survival among patients with metastatic melanoma, and only modest improvements were observed with interferon as an adjuvant drug. Ipilimumab, a monoclonal antibody...
Until recently, there was no systemic therapy shown to improve overall survival among patients with metastatic melanoma, and only modest improvements were observed with interferon as an adjuvant drug. Ipilimumab, a monoclonal antibody...
Until recently, there was no...
08/16/2012
First Report Managed Care
08/16/2012
Kevin L. Carter
The 5-year survival rate for adrenocortical carcinoma, a rare cancer with a poor prognosis, is <15% among patients with metastatic disease. Mitotane is the only drug approved for the treatment of adrenocortical carcinoma and is used both...
The 5-year survival rate for adrenocortical carcinoma, a rare cancer with a poor prognosis, is <15% among patients with metastatic disease. Mitotane is the only drug approved for the treatment of adrenocortical carcinoma and is used both...
The 5-year survival rate for...
08/16/2012
First Report Managed Care
08/16/2012
Kevin L. Carter
Although rapid whole-genome sequencing has been successfully used as a research tool with discriminatory power in outbreaks, it is also potentially useful for its possible clinical utility in a diagnostic setting. A compelling target is...
Although rapid whole-genome sequencing has been successfully used as a research tool with discriminatory power in outbreaks, it is also potentially useful for its possible clinical utility in a diagnostic setting. A compelling target is...
Although rapid whole-genome...
08/16/2012
First Report Managed Care
08/16/2012
Kevin L. Carter
The administration of radioiodine (131I) has traditionally been part of therapy to patients with thyroid cancer after thyroidectomy; however, it is unclear whether this administration provides any benefit after a complete surgical resection....
The administration of radioiodine (131I) has traditionally been part of therapy to patients with thyroid cancer after thyroidectomy; however, it is unclear whether this administration provides any benefit after a complete surgical resection....
The administration of...
08/16/2012
First Report Managed Care
08/16/2012
Kevin L. Carter
A major feature of Alzheimer disease (AD) is the deposition of brain amyloid-β (Aβ) peptide. IgG antibodies directed to Aβ naturally occur in the elderly, and their serum and cerebrospinal fluid levels may be significantly altered in the...
A major feature of Alzheimer disease (AD) is the deposition of brain amyloid-β (Aβ) peptide. IgG antibodies directed to Aβ naturally occur in the elderly, and their serum and cerebrospinal fluid levels may be significantly altered in the...
A major feature of Alzheimer...
08/16/2012
First Report Managed Care
08/16/2012
Kevin L. Carter
Thyroid cancer is the most common endocrine cancer, with >48,000 new cases occurring each year in the United States. Most cases are differentiated thyroid cancer, which is associated with a high 10-year survival rate of 90% to 95%. Many...
Thyroid cancer is the most common endocrine cancer, with >48,000 new cases occurring each year in the United States. Most cases are differentiated thyroid cancer, which is associated with a high 10-year survival rate of 90% to 95%. Many...
Thyroid cancer is the most...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Boston—Researchers found an association between adults of normal weight sleeping <6 hours per night and an increased risk of stroke symptoms, according to an analysis of 5666 people who were part of a large study that has tracked patients...
Boston—Researchers found an association between adults of normal weight sleeping <6 hours per night and an increased risk of stroke symptoms, according to an analysis of 5666 people who were part of a large study that has tracked patients...
Boston—Researchers found an...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Boston—According to a post hoc analysis of a double-blind, placebo-controlled cross-over study, patients who took 1.75 mg and 3.5 mg of zolpidem tartrate sublingual tablets had a significantly shorter time to sleep compared with those who...
Boston—According to a post hoc analysis of a double-blind, placebo-controlled cross-over study, patients who took 1.75 mg and 3.5 mg of zolpidem tartrate sublingual tablets had a significantly shorter time to sleep compared with those who...
Boston—According to a post hoc...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Philadelphia—A subanalysis of a major randomized blood pressure trial found that patients who are centrally obese and have type 2 diabetes do not benefit in terms of cardiovascular disease risk when they are treated aggressively to lower...
Philadelphia—A subanalysis of a major randomized blood pressure trial found that patients who are centrally obese and have type 2 diabetes do not benefit in terms of cardiovascular disease risk when they are treated aggressively to lower...
Philadelphia—A subanalysis of a...
08/16/2012
First Report Managed Care
08/16/2012
Eileen Koutnik-Fotopoulos
Philadelphia—Because a majority of diabetes patients are treated in the primary care setting, this has been a focus for diabetes improvement efforts. The patient-centered medical home (PCMH) model has gained national attention as an...
Philadelphia—Because a majority of diabetes patients are treated in the primary care setting, this has been a focus for diabetes improvement efforts. The patient-centered medical home (PCMH) model has gained national attention as an...
Philadelphia—Because a majority...
08/16/2012
First Report Managed Care
08/16/2012
Eileen Koutnik-Fotopoulos
Philadelphia—As the prevalence of diabetes continues to expand, the need for evidence-based management is becoming increasingly crucial. A study identified several clinical aspects of management of type 2 diabetes that warrant more education...
Philadelphia—As the prevalence of diabetes continues to expand, the need for evidence-based management is becoming increasingly crucial. A study identified several clinical aspects of management of type 2 diabetes that warrant more education...
Philadelphia—As the prevalence...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Philadelphia—A multicenter, cross-sectional, observational study found that clinicians had a poor record of diagnosing chronic kidney disease (CKD) in patients with type 2 diabetes. Prior to visiting a primary care clinic, only 12.1% of the...
Philadelphia—A multicenter, cross-sectional, observational study found that clinicians had a poor record of diagnosing chronic kidney disease (CKD) in patients with type 2 diabetes. Prior to visiting a primary care clinic, only 12.1% of the...
Philadelphia—A multicenter,...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Philadelphia—Managing patients with type 2 diabetes remains a major challenge, particularly when it comes to medication adherence, according to findings from an online, cross-sectional survey of patients and healthcare professionals. The...
Philadelphia—Managing patients with type 2 diabetes remains a major challenge, particularly when it comes to medication adherence, according to findings from an online, cross-sectional survey of patients and healthcare professionals. The...
Philadelphia—Managing patients...
08/16/2012
First Report Managed Care
08/16/2012
Tim Casey
Philadelphia—After >6 years of follow-up, a large, international, randomized trial found that daily injections of insulin glargine in patients with type 2 diabetes, or with a high risk of the disease, had a neutral effect on cancers,...
Philadelphia—After >6 years of follow-up, a large, international, randomized trial found that daily injections of insulin glargine in patients with type 2 diabetes, or with a high risk of the disease, had a neutral effect on cancers,...
Philadelphia—After >6 years...
08/16/2012
First Report Managed Care
08/15/2012
Tori Socha
Some individuals in the United States may be eligible to be enrolled simultaneously in 2 federally funded managed care systems: (1) the Medicare Advantage (MA) program, which is administered by the Centers for Medicare & Medicaid Services;...
Some individuals in the United States may be eligible to be enrolled simultaneously in 2 federally funded managed care systems: (1) the Medicare Advantage (MA) program, which is administered by the Centers for Medicare & Medicaid Services;...
Some individuals in the United...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
The model of care known as the patient-centered medical home (PCMH) is characterized by comprehensive primary care, improvement in quality of care, care management, and improved access to care in a patient-centered environment. Early studies...
The model of care known as the patient-centered medical home (PCMH) is characterized by comprehensive primary care, improvement in quality of care, care management, and improved access to care in a patient-centered environment. Early studies...
The model of care known as the...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
FDA resources dedicated to reviewing applications for drugs for humans and enduring efficacy and safety were augmented in 1992 with the passage of the Prescription Drug User Fee Act (PDUFA). To support the infrastructure required for review...
FDA resources dedicated to reviewing applications for drugs for humans and enduring efficacy and safety were augmented in 1992 with the passage of the Prescription Drug User Fee Act (PDUFA). To support the infrastructure required for review...
FDA resources dedicated to...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
The Patient Protection and Affordable Care Act (ACA) was designed to expand health insurance coverage, enhance access to primary care, and reduce potentially preventable visits to hospital emergency departments (EDs).
The Patient Protection and Affordable Care Act (ACA) was designed to expand health insurance coverage, enhance access to primary care, and reduce potentially preventable visits to hospital emergency departments (EDs).
The Patient Protection and...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
The American Recovery and Reinvestment Act of 2009 included a provision known as the Health Information Technology for Economic and Clinical Health (HITECH) Act. The HITECH Act provides funds for hospitals and clinicians to create and utilize...
The American Recovery and Reinvestment Act of 2009 included a provision known as the Health Information Technology for Economic and Clinical Health (HITECH) Act. The HITECH Act provides funds for hospitals and clinicians to create and utilize...
The American Recovery and...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Patients with multiple risk factors for cardiovascular disease, including hypertension, dyslipidemia, obesity, diabetes, and a family history of ischemic heart disease, are at moderate to high risk of cardiovascular events. For adults with...
Patients with multiple risk factors for cardiovascular disease, including hypertension, dyslipidemia, obesity, diabetes, and a family history of ischemic heart disease, are at moderate to high risk of cardiovascular events. For adults with...
Patients with multiple risk...
08/15/2012
First Report Managed Care
08/15/2012
Mary Beth Nierengarten
Results of a systematic review and meta-analysis [Arch Intern Med. 2012;172(10):761-769] did not find evidence showing that intensive glycemic control reduces the risk for significant clinical renal outcomes despite finding that it reduces...
Results of a systematic review and meta-analysis [Arch Intern Med. 2012;172(10):761-769] did not find evidence showing that intensive glycemic control reduces the risk for significant clinical renal outcomes despite finding that it reduces...
Results of a systematic review...
08/15/2012
First Report Managed Care
08/15/2012
Jill Sederstorm
Inpatient hospital costs are on the rise due primarily to a change in the intensity of services for patients, according to a new statistical brief released by the Healthcare Cost and Utilization Project (HCUP).
Inpatient hospital costs are on the rise due primarily to a change in the intensity of services for patients, according to a new statistical brief released by the Healthcare Cost and Utilization Project (HCUP).
Inpatient hospital costs are on...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Patients with spinal cord injury (SCI) or multiple sclerosis (MS) often experience neurogenic detrusor overactivity (NDO), which can lead to urodynamically measured increased bladder storage pressures and urinary incontinence (UI). Patients...
Patients with spinal cord injury (SCI) or multiple sclerosis (MS) often experience neurogenic detrusor overactivity (NDO), which can lead to urodynamically measured increased bladder storage pressures and urinary incontinence (UI). Patients...
Patients with spinal cord injury...
08/15/2012
First Report Managed Care
08/15/2012
Kristina Woodworth
The use of dual-chamber implantable cardioverter-defibrillators (ICDs) to prevent sudden death in patients without an indication for permanent pacing varies widely by region and hospital, according to the results of a cross-sectional study....
The use of dual-chamber implantable cardioverter-defibrillators (ICDs) to prevent sudden death in patients without an indication for permanent pacing varies widely by region and hospital, according to the results of a cross-sectional study....
The use of dual-chamber...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Patients with chronic obstructive pulmonary disease (COPD) often experience dyspnea on exertion (DOE), a difficult-to-control symptom. COPD is characterized by irreversible airflow limitation and, by 2020, is expected to be the third leading...
Patients with chronic obstructive pulmonary disease (COPD) often experience dyspnea on exertion (DOE), a difficult-to-control symptom. COPD is characterized by irreversible airflow limitation and, by 2020, is expected to be the third leading...
Patients with chronic...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Patients with osteoporosis benefit from treatment with bisphosphonates; the medications used to increase bone density and reduce the risk of vertebral and proximal femur fractures. However, according to researchers, the drugs have a...
Patients with osteoporosis benefit from treatment with bisphosphonates; the medications used to increase bone density and reduce the risk of vertebral and proximal femur fractures. However, according to researchers, the drugs have a...
Patients with osteoporosis...
08/15/2012
First Report Managed Care
08/15/2012
Jill Sederstorm
A new prospective study examining the relationship between postoperative troponin levels and mortality for noncardiac surgery patients found that there was a significant association between peak postoperative fourth-generation troponin T...
A new prospective study examining the relationship between postoperative troponin levels and mortality for noncardiac surgery patients found that there was a significant association between peak postoperative fourth-generation troponin T...
A new prospective study...
08/15/2012
First Report Managed Care
08/15/2012
Eileen Koutnik-Fotopoulos
Using a low-intensity physician staffing model (optional consultation with the intensivist) and Hhaving an intensivist working overnight were associated with decreased risk-adjusted in-hospital mortality among intensive care unit (ICU)...
Using a low-intensity physician staffing model (optional consultation with the intensivist) and Hhaving an intensivist working overnight were associated with decreased risk-adjusted in-hospital mortality among intensive care unit (ICU)...
Using a low-intensity physician...
08/15/2012
First Report Managed Care
08/15/2012
Mary Mihalovic
The risk of beginning prescription pain relievers for extramedical purposes peaks before the final year of high school, around the age of 16, and not during the college years as is commonly believed, according to results of a recent study...
The risk of beginning prescription pain relievers for extramedical purposes peaks before the final year of high school, around the age of 16, and not during the college years as is commonly believed, according to results of a recent study...
The risk of beginning...
08/15/2012
First Report Managed Care
08/15/2012
Mary Mihalovic
The use of warfarin for stroke prophylaxis in patients with nonvalvular atrial fibrillation (AF) was associated with a rate of stroke or systemic embolism of 1.66% per year, according to results of a recent meta-analysis [Arch Intern Med....
The use of warfarin for stroke prophylaxis in patients with nonvalvular atrial fibrillation (AF) was associated with a rate of stroke or systemic embolism of 1.66% per year, according to results of a recent meta-analysis [Arch Intern Med....
The use of warfarin for stroke...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Erythromycin and clarithromycin, broad-spectrum macrolide antibiotics, have been shown to increase the risk of serious ventricular arrhythmias and are associated with an increased risk of sudden cardiac death. Azithromycin is closely related...
Erythromycin and clarithromycin, broad-spectrum macrolide antibiotics, have been shown to increase the risk of serious ventricular arrhythmias and are associated with an increased risk of sudden cardiac death. Azithromycin is closely related...
Erythromycin and clarithromycin,...
08/15/2012
First Report Managed Care
08/15/2012
Eileen Koutnik-Fotopoulos
The Henry J. Kaiser Family Foundation has released a Medicare policy report titled Prescription Drug Procurement and the Federal Budget. Prescription drugs are a key area for potentially significant cost savings, but the May 2012 report by...
The Henry J. Kaiser Family Foundation has released a Medicare policy report titled Prescription Drug Procurement and the Federal Budget. Prescription drugs are a key area for potentially significant cost savings, but the May 2012 report by...
The Henry J. Kaiser Family...
08/15/2012
First Report Managed Care
08/15/2012
Eileen Koutnik-Fotopoulos
For patients 65 to 75 years of age newly diagnosed with multiple myeloma who were ineligible for transplant, treatment with lenalidomide maintenance therapy extended the time before relapse in a recent study [N Engl J Med....
For patients 65 to 75 years of age newly diagnosed with multiple myeloma who were ineligible for transplant, treatment with lenalidomide maintenance therapy extended the time before relapse in a recent study [N Engl J Med....
For patients 65 to 75 years of...
08/15/2012
First Report Managed Care
08/15/2012
Tim Casey
Chicago—Patients with gastrointestinal stromal tumors (GIST) whose disease progressed after taking 2 FDA-approved therapies (imatinib and sunitinib) had a significant increase in progression-free survival when taking regorafenib compared with...
Chicago—Patients with gastrointestinal stromal tumors (GIST) whose disease progressed after taking 2 FDA-approved therapies (imatinib and sunitinib) had a significant increase in progression-free survival when taking regorafenib compared with...
Chicago—Patients with...
08/15/2012
First Report Managed Care
08/15/2012
Tim Casey
Chicago—An interim analysis of a randomized, phase 3 trial of patients with metastatic castration-resistant prostate cancer (mCRPC) who had not received chemotherapy found that those taking abiraterone acetate plus prednisone had a...
Chicago—An interim analysis of a randomized, phase 3 trial of patients with metastatic castration-resistant prostate cancer (mCRPC) who had not received chemotherapy found that those taking abiraterone acetate plus prednisone had a...
Chicago—An interim analysis of a...
08/15/2012
First Report Managed Care
08/15/2012
Eileen Koutnik-Fotopoulos
Preoperative chemoradiotherapy improved survival among patients with resectable esophageal or esophagogastric-junction cancer with acceptable adverse events. The findings were reported in the New England Journal of Medicine...
Preoperative chemoradiotherapy improved survival among patients with resectable esophageal or esophagogastric-junction cancer with acceptable adverse events. The findings were reported in the New England Journal of Medicine...
Preoperative chemoradiotherapy...
08/15/2012
First Report Managed Care
08/15/2012
Kristina Woodworth
A recent study demonstrated no significant difference in time to ischemic stroke, intracerebral hemorrhage, or death from any cause in patients with reduced left ventricular ejection fraction (LVEF) and sinus rhythm who were treated with...
A recent study demonstrated no significant difference in time to ischemic stroke, intracerebral hemorrhage, or death from any cause in patients with reduced left ventricular ejection fraction (LVEF) and sinus rhythm who were treated with...
A recent study demonstrated no...
08/15/2012
First Report Managed Care
08/15/2012
Mary Beth Nierengarten
Results of a pooled patient-level meta-analysis [Arch Intern Med. 2012;172(8):611-621] comparing drug-eluting stents (DES) to bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary...
Results of a pooled patient-level meta-analysis [Arch Intern Med. 2012;172(8):611-621] comparing drug-eluting stents (DES) to bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary...
Results of a pooled...
08/15/2012
First Report Managed Care
08/15/2012
Tori Socha
Among patients with diabetes mellitus (DM), cardiovascular risk factors include high lipid levels and elevated blood pressure (BP). There has been significant improvement in the control of these factors over the past decade, an improvement...
Among patients with diabetes mellitus (DM), cardiovascular risk factors include high lipid levels and elevated blood pressure (BP). There has been significant improvement in the control of these factors over the past decade, an improvement...
Among patients with diabetes...
08/15/2012
First Report Managed Care
08/15/2012
Tim Casey
Since being sworn into office in January 2009, President Barack Obama has made revamping the healthcare industry a priority. Yet, his administration has said there is still a lot of work that needs to be done to reach their goals.
Since being sworn into office in January 2009, President Barack Obama has made revamping the healthcare industry a priority. Yet, his administration has said there is still a lot of work that needs to be done to reach their goals.
Since being sworn into office in...
08/15/2012
First Report Managed Care
08/15/2012
Tim Casey
For the most part, the health insurance industry felt relieved when the Supreme Court upheld the Patient Protection and Affordable Care Act (ACA) on June 28. Companies had been preparing for the law’s implementation for more than 2 years...
For the most part, the health insurance industry felt relieved when the Supreme Court upheld the Patient Protection and Affordable Care Act (ACA) on June 28. Companies had been preparing for the law’s implementation for more than 2 years...
For the most part, the health...
08/15/2012
First Report Managed Care