Miguel Regueiro, MD, on Updates in Post-Operative Crohn's Disease
Dr Regueiro provides updates on the care--and possible prevention of recurrence—of Crohn's disease following surgery, from his presentation at the 2025 AIBD Annual Meeting in Orlando, Florida.
Miguel Regueiro, MD, is professor of medicine and chair of the Digestive Disease Institute at Cleveland Clinic in Cleveland, Ohio.
TRANSCRIPT:
I am Dr. Miguel Regueiro. I'm chief of the Digestive Disease Institute at Cleveland Clinic in Cleveland, Ohio, and I'm at AIBD 2025 at our annual meeting in Orlando, Florida. And today I spoke on postoperative Crohn's disease. And while there are certain aspects of the talk that were not new, there are some new factors related to managing postoperative Crohn's disease.
One in particular has to do with environmental factors and specifically recent data and publications on e-cigarettes and vaping, which we now see to be a risk factor for postoperative recurrence, similar to what we see with cigarette smoking. Another area that we discussed, and this led to a robust discussion on the panel actually, were the ulcerations that can occur at the anastomosis. These have been debated for some time, and there was a bit of a split in opinion between Crohn's disease or whether these are ischemic-like ulcers.
In my opinion, based on some research we're doing, but not yet published these probably represent pathergy, meaning where the anastomosis and the way the patients are actually connected together, staplers, sutures, and the like.
And then finally, we discussed monitoring and some of the new therapies that are now coming out for postoperative Crohn's. Monitoring fecal calprotectin and intestinal ultrasound have become standard of care in a way of monitoring for postoperative Crohn's disease recurrence.
And then finally, medications. The TNF inhibitors are kind of the tried and true, but there are more data on vedolizumab as a postoperative management and prevention of recurrent Crohn's disease. So thank you very much. Coming to you from AIBD 2025.
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