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Hereditary Angioedema Topic Center

Research Review
Elevated Comorbidity Burden and Surgical Interventions in Patients With HAE-C1INH
03/18/2026
Jessica Garlewicz
Results of an analysis highlight the importance of integrating multisystem evaluation into the long-term care of HAE-C1INH patients, and stress the need for early and accurate diagnosis to prevent mismanagement and unnecessary procedures.
Results of an analysis highlight the importance of integrating multisystem evaluation into the long-term care of HAE-C1INH patients, and stress the need for early and accurate diagnosis to prevent mismanagement and unnecessary procedures.
Results of an analysis highlight...
03/18/2026
Allergy & Immunology
Research Review
Injectable On-Demand HAE Treatments Undermine Quality of Life, Study Finds
03/18/2026
Rebecca Mashaw
All participants reported at least one negative impact on HRQoL due to injectable on-demand treatment.
All participants reported at least one negative impact on HRQoL due to injectable on-demand treatment.
All participants reported at...
03/18/2026
Allergy & Immunology
Research Review
Oral Therapies Expand Options for Personalized Management of Hereditary Angioedema
03/18/2026
Jessica Garlewicz
This analysis highlights the emergence of oral agents as a practical alternative to parenteral therapies for both prophylaxis and acute attack management
This analysis highlights the emergence of oral agents as a practical alternative to parenteral therapies for both prophylaxis and acute attack management
This analysis highlights the...
03/18/2026
Allergy & Immunology
Research Highlights
Global Physician Survey Identifies Persistent Gaps in Achieving Treatment Goals for Hereditary Angioedema
03/18/2026
Jessica Garlewicz
The results of a physician survey highlight ongoing barriers to implementing consensus recommendations and underscore the need for broader education and improved access to therapy for HAE.
The results of a physician survey highlight ongoing barriers to implementing consensus recommendations and underscore the need for broader education and improved access to therapy for HAE.
The results of a physician...
03/18/2026
Allergy & Immunology
Research Summary
Berotralstat Associated With Significant Reductions in Healthcare Utilization in HAE With Normal C1-Inhibitor
03/04/2026
Riya Gandhi, MA
A retrospective analysis presented at the AAAAI meeting shows that oral prophylaxis with berotralstat may reduce acute care utilization for HAE-nC1INH in a population historically limited in treatment options.
A retrospective analysis presented at the AAAAI meeting shows that oral prophylaxis with berotralstat may reduce acute care utilization for HAE-nC1INH in a population historically limited in treatment options.
A retrospective analysis...
03/04/2026
Allergy & Immunology
Emerging Therapies
Advances in HAE Therapeutics Highlight Path Toward Personalized, Patient-Centered Care
03/02/2026
Jessica Garlewicz
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management...
03/02/2026
Allergy & Immunology
Allen Kaplan
RESEARCH INSIGHTS
Diagnostic Challenges and Clinical Pitfalls in HAE
03/02/2026
Allen P. Kaplan, MD
Dr Allen Kaplan reviews common diagnostic pitfalls in hereditary angioedema, including misinterpretation of complement testing, confusion with histaminergic angioedema, and challenges in identifying HAE with normal C1 inhibitor.
Dr Allen Kaplan reviews common diagnostic pitfalls in hereditary angioedema, including misinterpretation of complement testing, confusion with histaminergic angioedema, and challenges in identifying HAE with normal C1 inhibitor.
Dr Allen Kaplan reviews common...
03/02/2026
Allergy & Immunology
Quiz
Future Therapies in HAE: What’s Driving Innovation?
03/01/2026
Riya Gandhi, MA
Dive into next-generation treatment strategies in hereditary angioedema in reshaping long-term care.
Dive into next-generation treatment strategies in hereditary angioedema in reshaping long-term care.
Dive into next-generation...
03/01/2026
Allergy & Immunology
Allen Kaplan
CLINICAL INSIGHTS
Differentiating Hereditary Angioedema From Its Mimics
02/09/2026
Allen P. Kaplan, MD
Allen Kaplan, MD, discusses how to distinguish hereditary angioedema from common angioedema mimics, including histaminergic and ACE inhibitor–associated angioedema.
Allen Kaplan, MD, discusses how to distinguish hereditary angioedema from common angioedema mimics, including histaminergic and ACE inhibitor–associated angioedema.
Allen Kaplan, MD, discusses how...
02/09/2026
Allergy & Immunology
Research Summary
Barriers to Normalization Persist for U.S. Patients With Hereditary Angioedema
01/18/2026
Rebecca Mashaw
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight...
01/18/2026
Allergy & Immunology
Research Highlights
Updated International Consensus on HAE-nC1INH Diagnosis and Treatment
01/16/2026
Rebecca Mashaw
The 2025 global consensus represents a major step forward in unifying global expert opinion on HAE-nC1INH diagnosis and care.
The 2025 global consensus represents a major step forward in unifying global expert opinion on HAE-nC1INH diagnosis and care.
The 2025 global consensus...
01/16/2026
Allergy & Immunology

In the News

Emerging Therapies
Advances in HAE Therapeutics Highlight Path Toward Personalized, Patient-Centered Care
03/02/2026
Jessica Garlewicz
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management...
03/02/2026
Allergy & Immunology
Research Summary
Barriers to Normalization Persist for U.S. Patients With Hereditary Angioedema
01/18/2026
Rebecca Mashaw
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight...
01/18/2026
Allergy & Immunology
Research Highlights
Elevated Comorbidity Burden and Surgical Interventions in Patients With HAE-C1INH
12/06/2025
Jessica Garlewicz
Study findings underscore the need for heightened clinical surveillance and early recognition to avoid unnecessary procedures and improve long-term patient outcomes.
Study findings underscore the need for heightened clinical surveillance and early recognition to avoid unnecessary procedures and improve long-term patient outcomes.
Study findings underscore the...
12/06/2025
Allergy & Immunology
Clinical Trials
Deucrictibant Demonstrates Durable Efficacy and Safety in Long-Term Prophylaxis of Hereditary Angioedema
11/13/2025
Jessica Garlewicz
Interim results from the open-label extension of the CHAPTER-1 phase 2 trial support the long-term efficacy and safety of deucrictibant, an oral bradykinin B2 receptor antagonist, for hereditary angioedema prophylaxis
Interim results from the open-label extension of the CHAPTER-1 phase 2 trial support the long-term efficacy and safety of deucrictibant, an oral bradykinin B2 receptor antagonist, for hereditary angioedema prophylaxis
Interim results from the...
11/13/2025
Allergy & Immunology
Research Review
Higher Phytochemical Intake Linked to Improved Pediatric Asthma Outcomes
03/18/2026
Rebecca Mashaw
Among the 150 children with asthma, those with higher Dietary Phytochemical Index intake had significantly better clinical scores and lower levels of inflammation than those in the lowest tertile.
Among the 150 children with asthma, those with higher Dietary Phytochemical Index intake had significantly better clinical scores and lower levels of inflammation than those in the lowest tertile.
Among the 150 children with...
03/18/2026
Allergy & Immunology
Research Summary
Acute Urticaria Incidence Declined During COVID-19
03/18/2026
Jessica Garlewicz
The findings of an analysis underscore the potential role of common viral infections as a trigger for AU and offer insight into changing disease patterns during the COVID-19 pandemic.
The findings of an analysis underscore the potential role of common viral infections as a trigger for AU and offer insight into changing disease patterns during the COVID-19 pandemic.
The findings of an analysis...
03/18/2026
Allergy & Immunology
Emerging Therapies
Advances in HAE Therapeutics Highlight Path Toward Personalized, Patient-Centered Care
03/02/2026
Jessica Garlewicz
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management...
03/02/2026
Allergy & Immunology
FDA Alert
FDA Approves Twice-Yearly Biologic for Severe Eosinophilic Asthma
02/18/2026
Jessica Garlewicz
Exdensur is the first ultra-long-acting biologic for this population, with a dosing schedule of just twice per year.
Exdensur is the first ultra-long-acting biologic for this population, with a dosing schedule of just twice per year.
Exdensur is the first...
02/18/2026
Allergy & Immunology
Research Review
MDD in Asthma Patients Associated With Worse Outcomes in Older Adults
01/29/2026
Rebecca Mashaw
A recent cohort study by highlights how psychological health influences asthma control and healthcare utilization, underscoring a need for integrated care in older populations.
A recent cohort study by highlights how psychological health influences asthma control and healthcare utilization, underscoring a need for integrated care in older populations.
A recent cohort study by...
01/29/2026
Allergy & Immunology
Research Summary
Barriers to Normalization Persist for U.S. Patients With Hereditary Angioedema
01/18/2026
Rebecca Mashaw
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight...
01/18/2026
Allergy & Immunology
Comorbidities
Oscillometry-Based Markers Reveal Airway Dynamics in Asthma–OSA Overlap
12/06/2025
Jessica Garlewicz
While the exact mechanistic interactions remain complex, oscillometric patterns provided insight into changes in respiratory rhythm and resistance related to nocturnal airway collapse and remodeling.
While the exact mechanistic interactions remain complex, oscillometric patterns provided insight into changes in respiratory rhythm and resistance related to nocturnal airway collapse and remodeling.
While the exact mechanistic...
12/06/2025
Allergy & Immunology
Morbidity & Mortality
Mortality From Coexisting Asthma and Cardiovascular Disease Rising
12/06/2025
Jessica Garlewicz
This analysis found significant disparities in mortality across demographic groups.
This analysis found significant disparities in mortality across demographic groups.
This analysis found significant...
12/06/2025
Allergy & Immunology
Research Highlights
Elevated Comorbidity Burden and Surgical Interventions in Patients With HAE-C1INH
12/06/2025
Jessica Garlewicz
Study findings underscore the need for heightened clinical surveillance and early recognition to avoid unnecessary procedures and improve long-term patient outcomes.
Study findings underscore the need for heightened clinical surveillance and early recognition to avoid unnecessary procedures and improve long-term patient outcomes.
Study findings underscore the...
12/06/2025
Allergy & Immunology
News
Blastocystis Colonization Alters Gut Microbiota in Patients With Urticaria
12/06/2025
Jessica Garlewicz
New evidence suggests that blastocystis infection may contribute to immune dysregulation in urticaria through alterations in the intestinal microbiota.
New evidence suggests that blastocystis infection may contribute to immune dysregulation in urticaria through alterations in the intestinal microbiota.
New evidence suggests that...
12/06/2025
Allergy & Immunology

Popular Articles

Patient-Reported Outcomes
Injectable On-Demand HAE Treatments Undermine Quality of Life, Study Finds
12/06/2025
Jessica Garlewicz
This analysis highlights the persistent challenges that impact health-related quality of life (HRQoL) across emotional, social, and practical domains.
This analysis highlights the persistent challenges that impact health-related quality of life (HRQoL) across emotional, social, and practical domains.
This analysis highlights the...
12/06/2025
Allergy & Immunology
RESEARCH INSIGHTS
Thomas Casale, MD, on the Efficacy of Dupilumab for Chronic Spontaneous Urticaria
03/13/2026
Thomas B. Casale, MD
Dr Casale provides an overview of his poster presentation at the American Academy of Allergy, Asthma, and Immunology annual meeting on whether age, gender, BMI, presence of angioedema, or IgE level affected how patients with chronic...
Dr Casale provides an overview of his poster presentation at the American Academy of Allergy, Asthma, and Immunology annual meeting on whether age, gender, BMI, presence of angioedema, or IgE level affected how patients with chronic...
Dr Casale provides an overview...
03/13/2026
Allergy & Immunology
Atopic dermatitis
Quiz
The Overlooked Allergen Missing from Most Patch Test Panels
07/25/2025
Riya Gandhi, MA
Think you’re testing for all the right allergens? Take the quiz to learn which emerging culprit in skincare often flies under the radar.
Think you’re testing for all the right allergens? Take the quiz to learn which emerging culprit in skincare often flies under the radar.
Think you’re testing for all the...
07/25/2025
The Dermatologist
Quiz
Skin Barrier Abnormalities and Immune Triggers in Pediatric AD
03/05/2026
Riya Gandhi, MA
Explore how structural changes in the skin contribute to systemic immune activation in children with atopic dermatitis. This quiz highlights key pathophysiologic drivers relevant to clinical care.
Explore how structural changes in the skin contribute to systemic immune activation in children with atopic dermatitis. This quiz highlights key pathophysiologic drivers relevant to clinical care.
Explore how structural changes...
03/05/2026
Allergy & Immunology
News
Outpatient Study Highlights Effectiveness of Penicillin Allergy Delabeling via Oral Challenge
11/17/2025
Jessica Garlewicz
A retrospective chart review conducted at an outpatient allergy clinic found that oral drug challenges are safe and highly effective for penicillin allergy delabeling.
A retrospective chart review conducted at an outpatient allergy clinic found that oral drug challenges are safe and highly effective for penicillin allergy delabeling.
A retrospective chart review...
11/17/2025
Allergy & Immunology

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