MicroRNA Networks Identified as Central Regulators in Psoriasis Pathogenesis
MicroRNAs (miRNAs) may represent a critical regulatory layer in psoriasis, linking immune activation, keratinocyte dysfunction, and genetic susceptibility, according to a comprehensive review examining emerging molecular insights in the disease. The findings highlight the potential of miRNAs as biomarkers and future therapeutic targets in precision dermatology.
Psoriasis is driven by sustained inflammation and abnormal keratinocyte proliferation. The review outlines how dysregulated miRNAs function as post-transcriptional regulators coordinating immune and epidermal pathways. Proinflammatory miRNAs, including miR-21, miR-31, miR-155, and miR-210, promote Th17 signaling and inflammatory cascades. In contrast, miR-125b, miR-146a, and miR-99a act as anti-inflammatory modulators that help maintain immune balance.
Beyond local skin effects, circulating and extracellular vesicle–associated miRNAs are proposed as noninvasive biomarkers. These molecular signatures may reflect disease severity and therapeutic response, offering potential for longitudinal monitoring. The authors note that “circulating and extracellular vesicle-associated miRNAs are non-invasive biomarkers that reflect disease severity and therapeutic response.”
The review also describes how miRNA networks interact with long non-coding RNAs and circular RNAs within competing endogenous RNA systems. This dynamic crosstalk integrates keratinocyte and immune cell pathways, reinforcing psoriasis as a systems-level inflammatory disorder.
Therapeutic modulation of miRNAs is under investigation. Strategies such as antagomiRs, miRNA mimics, and nanocarrier-based delivery are being explored to restore molecular balance in psoriatic lesions. According to the authors, “miRNAs represent a critical epigenetic layer that bridges molecular pathology and clinical application,” underscoring their translational relevance.
Integration of miRNA profiling with multi-omics data and machine learning is also highlighted as a pathway toward precision diagnostics and patient stratification. These approaches may eventually support individualized treatment selection.
Reference
Singh H, Jha H, Taliyan R. Regulatory roles of microRNAs in epigenetic and immune gene networks in psoriasis. Gene. Published online February 28, 2026. doi:10.1016/j.gene.2026.150081
