A Case Series for Management of Complicated Diabetic Foot Wounds

Introduction: Diabetic foot ulcers (DFUs) are a very common side effect of diabetes and are considered as chronic wounds that impact healthcare systems and patient quality of life. Even more problematic are patients with significant co-morbidities and a history of complica- tions. For many patients, the standard of care is not enough to get their wound closed, necessitating advanced wound care products like human placental membranes. These products are intended as a covering for acute and chronic wounds. We are reporting three cases of DFU patients who received placental allografts using a proprietary processing method (RE-AC). Methods: Case one shows a diabetic patient with a previous 5th partial ray amputation presenting with macerated, undermined ulcers of the foot. RE-AC (AW2) was applied to these wounds every 7 days with the ex- ception of one missed treatment. Case two shows a diabetic patient with Charcot arthropathy. The patient had osteomyelitis of the foot, cellulitis and probing to the bone. RE-AC (AW2) was applied to these wounds ev- ery 7 days. Case three shows a diabetic patient with multiple amputations developed necrosis on the right foot down to the bone. RE-AC (AW2) was applied to these wounds every 7 days. Results: The application of RE-AC proved to be very effective in the treatment of these patients. The patients demonstrated clinical improve- ment with within one to three applications of the skin substitute. Two of the three patients went on to complete closure. Discussion: Even in the most challenging cases, the use of this RE-AC, as a wound covering, offers significant improvement in the timeline to closure, which reduces the risk for limb threatening infection, and allowing the patient to return to a more normal lifestyle. This translates to reduced treatment costs, and optimized resource utilization in a healthcare setting.