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Primary Humoral Immunodeficiency Topic Center

Exclusives

News
06/22/2023
Jolynn Tumolo
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management,...
06/22/2023
Rheumatology & Arthritis
laptop with stethoscope
News
06/08/2023
Jolynn Tumolo
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health...
06/08/2023
Rheumatology & Arthritis
gastrointestinal
News
05/31/2023
Jolynn Tumolo
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of...
05/31/2023
Rheumatology & Arthritis
infection + immunology
News
05/24/2023
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic...
05/24/2023
Rheumatology & Arthritis
News
03/16/2023
Jolynn Tumolo
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most...
03/16/2023
Rheumatology & Arthritis
News
12/11/2022
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common...
12/11/2022
Rheumatology & Arthritis
News
11/29/2022
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial...
11/29/2022
Rheumatology & Arthritis
News
11/03/2022
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether...
11/03/2022
Rheumatology & Arthritis
News
10/27/2022
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence...
10/27/2022
Rheumatology & Arthritis
News
10/27/2022
Patients who are moderately or severely immunocompromised are encouraged to stay up to date with their COVID-19 and influenza vaccination schedules in order to stay healthy this flu season.
Patients who are moderately or severely immunocompromised are encouraged to stay up to date with their COVID-19 and influenza vaccination schedules in order to stay healthy this flu season.
Patients who are moderately or...
10/27/2022
Rheumatology & Arthritis
News
10/26/2022
Patients diagnosed with immune thrombocytopenia were often found to have comorbid thyroid disease.
Patients diagnosed with immune thrombocytopenia were often found to have comorbid thyroid disease.
Patients diagnosed with immune...
10/26/2022
Rheumatology & Arthritis

News

News
06/22/2023
Jolynn Tumolo
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management,...
06/22/2023
Rheumatology & Arthritis
laptop with stethoscope
News
06/08/2023
Jolynn Tumolo
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health...
06/08/2023
Rheumatology & Arthritis
gastrointestinal
News
05/31/2023
Jolynn Tumolo
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of...
05/31/2023
Rheumatology & Arthritis
infection + immunology
News
05/24/2023
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic...
05/24/2023
Rheumatology & Arthritis
News
03/16/2023
Jolynn Tumolo
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most...
03/16/2023
Rheumatology & Arthritis
News
01/24/2023
Patients with immunocompromised systems may suffer from severe manifestations from Mpox, warns the latest update from the U.S. Centers for Disease Control and Prevention.
Patients with immunocompromised systems may suffer from severe manifestations from Mpox, warns the latest update from the U.S. Centers for Disease Control and Prevention.
Patients with immunocompromised...
01/24/2023
Rheumatology & Arthritis
News
12/11/2022
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common...
12/11/2022
Rheumatology & Arthritis
News
11/29/2022
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial...
11/29/2022
Rheumatology & Arthritis
News
11/03/2022
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether...
11/03/2022
Rheumatology & Arthritis
News
10/27/2022
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence...
10/27/2022
Rheumatology & Arthritis
News
09/18/2025
Jessica Garlewicz
For rheumatologists, the findings suggest that digital mental health tools may serve as accessible, scalable adjuncts to traditional care, addressing the unmet psychological needs often seen in this patient population.
For rheumatologists, the findings suggest that digital mental health tools may serve as accessible, scalable adjuncts to traditional care, addressing the unmet psychological needs often seen in this patient population.
For rheumatologists, the...
09/18/2025
Rheumatology & Arthritis
News
09/18/2025
Jessica Garlewicz
Recognizing whether an IMID predates or follows cancer diagnosis may guide clinical decisions regarding immunosuppression, surveillance, and therapy sequencing.
Recognizing whether an IMID predates or follows cancer diagnosis may guide clinical decisions regarding immunosuppression, surveillance, and therapy sequencing.
Recognizing whether an IMID...
09/18/2025
Rheumatology & Arthritis
News
09/18/2025
Jessica Garlewicz
The consensus represents a unified step toward greater precision and recognition of this often misunderstood autoimmune condition.
The consensus represents a unified step toward greater precision and recognition of this often misunderstood autoimmune condition.
The consensus represents a...
09/18/2025
Rheumatology & Arthritis
Research Highlights
09/15/2025
Riya Gandhi, MA
A prospective cohort study finds that poor sleep consistently predicts greater pain-related interference with daily life 6 months later in patients with early RA, suggesting sleep as a potential target for improving long-term pain outcomes.
A prospective cohort study finds that poor sleep consistently predicts greater pain-related interference with daily life 6 months later in patients with early RA, suggesting sleep as a potential target for improving long-term pain outcomes.
A prospective cohort study finds...
09/15/2025
Rheumatology & Arthritis
News
09/15/2025
Riya Gandhi, MA
A longitudinal study reveals that higher perceived stress independently predicts poorer symptom outcomes in RA, highlighting the potential benefit of integrating psychosocial interventions into standard care.
A longitudinal study reveals that higher perceived stress independently predicts poorer symptom outcomes in RA, highlighting the potential benefit of integrating psychosocial interventions into standard care.
A longitudinal study reveals...
09/15/2025
Rheumatology & Arthritis
Research Highlights
09/15/2025
Riya Gandhi, MA
A multidisciplinary lifestyle program combining a whole-food, plant-based diet, exercise, and stress management led to lasting reductions in symptoms of RA and osteoarthritis, with improvements maintained 2 years after the intervention.
A multidisciplinary lifestyle program combining a whole-food, plant-based diet, exercise, and stress management led to lasting reductions in symptoms of RA and osteoarthritis, with improvements maintained 2 years after the intervention.
A multidisciplinary lifestyle...
09/15/2025
Rheumatology & Arthritis
News
09/15/2025
Riya Gandhi, MA
A propensity score–matched cohort study reveals that febuxostat use carries a significantly higher risk of liver enzyme abnormalities than benzbromarone, particularly among patients with pre-existing liver function elevations.
A propensity score–matched cohort study reveals that febuxostat use carries a significantly higher risk of liver enzyme abnormalities than benzbromarone, particularly among patients with pre-existing liver function elevations.
A propensity score–matched...
09/15/2025
Rheumatology & Arthritis
News
09/15/2025
Riya Gandhi, MA
A post hoc analysis of a randomized clinical trial finds no consistent link between plasma colchicine concentrations and flare prevention or adverse effects—challenging the utility of therapeutic drug monitoring in routine gout care.
A post hoc analysis of a randomized clinical trial finds no consistent link between plasma colchicine concentrations and flare prevention or adverse effects—challenging the utility of therapeutic drug monitoring in routine gout care.
A post hoc analysis of a...
09/15/2025
Rheumatology & Arthritis
Research Highlights
09/15/2025
Riya Gandhi, MA
New research identifies social and clinical factors—such as marital status, age, and colchicine use—that may influence whether patients seek outpatient care after visiting the emergency department for a gout flare.
New research identifies social and clinical factors—such as marital status, age, and colchicine use—that may influence whether patients seek outpatient care after visiting the emergency department for a gout flare.
New research identifies social...
09/15/2025
Rheumatology & Arthritis

Interactive Features

Quiz
08/07/2025
Rebecca Mashaw
Do men or women achieve better outcomes with advanced therapies for axial spondyloarthritis? Find out by taking our quick quiz.
Do men or women achieve better outcomes with advanced therapies for axial spondyloarthritis? Find out by taking our quick quiz.
Do men or women achieve better...
08/07/2025
Rheumatology & Arthritis
Quiz
08/07/2025
Rebecca Mashaw
One factor showed a substantial association with mortality among patients with rheumatoid arthritis. Find out what it is with our quiz!
One factor showed a substantial association with mortality among patients with rheumatoid arthritis. Find out what it is with our quiz!
One factor showed a substantial...
08/07/2025
Rheumatology & Arthritis
Quiz
07/21/2025
Rebecca Mashaw
07/21/2025
Rheumatology & Arthritis
Quiz
08/30/2024
Riya Gandhi, MA
Is there any association between nonsteroidal anti-inflammatory drugs (NSAIDs), axial spondyloarthritis (axSpA), and risk of cardiovascular disease (CVD)?a) No, there is no evidence that NSAID use increases the risk of CVD on patients with...
Is there any association between nonsteroidal anti-inflammatory drugs (NSAIDs), axial spondyloarthritis (axSpA), and risk of cardiovascular disease (CVD)?a) No, there is no evidence that NSAID use increases the risk of CVD on patients with...
Is there any association between...
08/30/2024
Rheumatology & Arthritis
Quiz
08/07/2024
Rebecca Mashaw
What demographic characteristics are typical of patients with axial spondyloarthritis? Learn more when you take our quick quiz!
What demographic characteristics are typical of patients with axial spondyloarthritis? Learn more when you take our quick quiz!
What demographic characteristics...
08/07/2024
Rheumatology & Arthritis
Quiz
03/14/2024

Priyam Vora, Associate Editor

Priyam Vora, Associate Editor
Is obesity a risk and severity factor among patients with rheumatic conditions? Or does weight have no bearing on autoimmune disorders? Find out with one quick question!
Is obesity a risk and severity factor among patients with rheumatic conditions? Or does weight have no bearing on autoimmune disorders? Find out with one quick question!
Is obesity a risk and severity...
03/14/2024
Rheumatology & Arthritis
Quiz
02/22/2024
Priyam Vora
Researchers developed the Psoriatic Arthritis Risk Estimation Tool (PRESTO) to predict the 1- and 5-year risk of developing psoriatic arthritis in patients with psoriasis. Take our quiz to test your knowledge on the subject!
Researchers developed the Psoriatic Arthritis Risk Estimation Tool (PRESTO) to predict the 1- and 5-year risk of developing psoriatic arthritis in patients with psoriasis. Take our quiz to test your knowledge on the subject!
Researchers developed the...
02/22/2024
Rheumatology & Arthritis
Quiz
02/06/2024
Priyam Vora
Take a quick quiz to test your knowledge on gout, a form of arthritis typically characterized by severe pain, redness, and tenderness in joints.
Take a quick quiz to test your knowledge on gout, a form of arthritis typically characterized by severe pain, redness, and tenderness in joints.
Take a quick quiz to test your...
02/06/2024
Rheumatology & Arthritis
spinal xray
Quiz
02/01/2024
A retrospective cohort study identified 1426 adults with prevalent ankylosing spondylitis. Do you know the characteristic with the highest odds ratio to fractures among these patients? Take our quiz to test your knowledge!
A retrospective cohort study identified 1426 adults with prevalent ankylosing spondylitis. Do you know the characteristic with the highest odds ratio to fractures among these patients? Take our quiz to test your knowledge!
A retrospective cohort study...
02/01/2024
Rheumatology & Arthritis

Podcasts

Dacre Knight
Podcast
04/30/2025
Dacre Knight, MD
Dacre Knight, MD, from Mayo Clinic-Florida, provides insights into hypermobility disorders, including Ehlers-Danlos Syndrome, and why they are difficult to diagnose and challenging to treat.
Dacre Knight, MD, from Mayo Clinic-Florida, provides insights into hypermobility disorders, including Ehlers-Danlos Syndrome, and why they are difficult to diagnose and challenging to treat.
Dacre Knight, MD, from Mayo...
04/30/2025
Rheumatology & Arthritis
Len Calabrese
Podcast
01/02/2025
Leonard Calabrese, DO
Dr Calabrese discusses the similarities between long COVID, fibromyalgia, and in its most severe form, myalgic encephalomyelitis/chronic fatigue syndrome, and the importance of reassuring patients that their symptoms and conditions are real.
Dr Calabrese discusses the similarities between long COVID, fibromyalgia, and in its most severe form, myalgic encephalomyelitis/chronic fatigue syndrome, and the importance of reassuring patients that their symptoms and conditions are real.
Dr Calabrese discusses the...
01/02/2025
Rheumatology & Arthritis
Misti Paudel
Podcast
08/12/2024
Dr Paudel reviews research she and colleagues conducted to validate the EULAR definition of difficult-to-treat rheumatoid arthritis, and differences among patients with difficult-to-treat RA versus those with controlled disease.
Dr Paudel reviews research she and colleagues conducted to validate the EULAR definition of difficult-to-treat rheumatoid arthritis, and differences among patients with difficult-to-treat RA versus those with controlled disease.
Dr Paudel reviews research she...
08/12/2024
Rheumatology & Arthritis
Vikas Majithia
Podcast
06/20/2024
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck...
06/20/2024
Rheumatology & Arthritis
Podcast
04/08/2024
In this podcast, Drs England and Smith discuss the key recommendations and how to implement exercise, rehabilitation, diet, and additional interventions as part of an integrative management approach for people with rheumatoid arthritis.
In this podcast, Drs England and Smith discuss the key recommendations and how to implement exercise, rehabilitation, diet, and additional interventions as part of an integrative management approach for people with rheumatoid arthritis.
In this podcast, Drs England and...
04/08/2024
Rheumatology & Arthritis
Dr Shari Lipner
Podcast
03/27/2024
Shari Lipner, MD, PhD
In a cross-sectional study of 36 isolated nail psoriasis patients, 7 of them (19%) went on to develop psoriatic arthritis in the following years. Is there more to this connection between isolated nail psoriasis and early detection of PsA? Dr...
In a cross-sectional study of 36 isolated nail psoriasis patients, 7 of them (19%) went on to develop psoriatic arthritis in the following years. Is there more to this connection between isolated nail psoriasis and early detection of PsA? Dr...
In a cross-sectional study of 36...
03/27/2024
Rheumatology & Arthritis
Jeff Sparks
Podcast
03/14/2024
Dr Jeffrey Sparks and research assistant Emily Kowalski from Brigham & Women's Hospital in Boston share their findings from a study of the risk factors found among patient with systemic rheumatic diseases for repeat infections with COVID-19.
Dr Jeffrey Sparks and research assistant Emily Kowalski from Brigham & Women's Hospital in Boston share their findings from a study of the risk factors found among patient with systemic rheumatic diseases for repeat infections with COVID-19.
Dr Jeffrey Sparks and research...
03/14/2024
Rheumatology & Arthritis
Neal Birnbam
Podcast
03/08/2024
Dr Birnbaum comments on how the new rule from the Centers for Medicare & Medicaid Services setting tighter timelines for health insurers to act on requests for authorization for medications and procedures.
Dr Birnbaum comments on how the new rule from the Centers for Medicare & Medicaid Services setting tighter timelines for health insurers to act on requests for authorization for medications and procedures.
Dr Birnbaum comments on how the...
03/08/2024
Rheumatology & Arthritis
Len Calabrese
Podcast
02/29/2024
Dr Leonard Calabrese of the Cleveland Clinic discusses the similarities and differences of fibromyalgia, chronic fatigue syndrome, and long COVID, and why classifying these diseases properly is important to diagnosis and treatment.
Dr Leonard Calabrese of the Cleveland Clinic discusses the similarities and differences of fibromyalgia, chronic fatigue syndrome, and long COVID, and why classifying these diseases properly is important to diagnosis and treatment.
Dr Leonard Calabrese of the...
02/29/2024
Rheumatology & Arthritis
GLN logo
Podcast
01/23/2024
Rita Knotts, MD; Elizabeth Volkmann, MD, MS
In this special podcast Dr Rita Knotts, with the Center for Esophageal Health at NYU-Langone, and Dr Elizabeth Volkmann, founder and codirector of the UCLA Connective Tissue Disease-Related Interstitial Lung Disease, discuss the intersection...
In this special podcast Dr Rita Knotts, with the Center for Esophageal Health at NYU-Langone, and Dr Elizabeth Volkmann, founder and codirector of the UCLA Connective Tissue Disease-Related Interstitial Lung Disease, discuss the intersection...
In this special podcast Dr Rita...
01/23/2024
Rheumatology & Arthritis