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Depression Topic Center

A lab tech handles psilocybin research
FDA Update
04/29/2026
Brionna Mendoza
Following an April 18 executive order, the US Food and Drug Administration (FDA) announced new regulatory actions to accelerate the development of psychedelic-assisted therapy for mental health conditions.
Following an April 18 executive order, the US Food and Drug Administration (FDA) announced new regulatory actions to accelerate the development of psychedelic-assisted therapy for mental health conditions.
Following an April 18 executive...
04/29/2026
Psych Congress Network
A patient receives psychedelic-assisted therapy
News
04/29/2026
Brionna Mendoza
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed...
04/29/2026
Psych Congress Network
a woman sits on a windowsill and looks out the window
Research Summary
03/27/2026
Brionna Mendoza
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical...
03/27/2026
Psych Congress Network
A woman lies on the couch holding an ice pack to her head
News
03/10/2026
Brionna Mendoza
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2...
03/10/2026
Psych Congress Network
Ketogenic diet for depression keto healthy fats
News
02/10/2026
Brionna Mendoza
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial...
02/10/2026
Psych Congress Network
An orange prescription container with generic pills spilling out in front of it
News
02/03/2026
Brionna Mendoza
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study...
02/03/2026
Psych Congress Network
A frustrated man works on a laptop
News
01/23/2026
Maria Mantas
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent...
01/23/2026
Psych Congress Network
a depressed teen adolescent holds head in hands crying upset sad major depression
News
01/20/2026
Brionna Mendoza
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized...
01/20/2026
Psych Congress Network
woman experiencing depression
Research Summary
12/01/2025
Maria Mantas
A systematic review and meta-analysis of 7 clinical trials and 4 published protocol papers found that nitrous oxide (N2O) may offer rapid-acting benefit for the treatment of depression.
A systematic review and meta-analysis of 7 clinical trials and 4 published protocol papers found that nitrous oxide (N2O) may offer rapid-acting benefit for the treatment of depression.
A systematic review and...
12/01/2025
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
11/19/2025
Brionna Mendoza
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
11/19/2025
Psych Congress Network
open and spilled bottle of pills
News
11/03/2025
Maria Mantas
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic...
11/03/2025
Psych Congress Network

News

A patient receives psychedelic-assisted therapy
News
04/29/2026
Brionna Mendoza
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed...
04/29/2026
Psych Congress Network
a woman sits on a windowsill and looks out the window
Research Summary
03/27/2026
Brionna Mendoza
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical...
03/27/2026
Psych Congress Network
A woman lies on the couch holding an ice pack to her head
News
03/10/2026
Brionna Mendoza
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2...
03/10/2026
Psych Congress Network
Ketogenic diet for depression keto healthy fats
News
02/10/2026
Brionna Mendoza
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial...
02/10/2026
Psych Congress Network
An orange prescription container with generic pills spilling out in front of it
News
02/03/2026
Brionna Mendoza
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study...
02/03/2026
Psych Congress Network
A frustrated man works on a laptop
News
01/23/2026
Maria Mantas
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent...
01/23/2026
Psych Congress Network
a depressed teen adolescent holds head in hands crying upset sad major depression
News
01/20/2026
Brionna Mendoza
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized...
01/20/2026
Psych Congress Network
open and spilled bottle of pills
News
11/03/2025
Maria Mantas
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic...
11/03/2025
Psych Congress Network
brain
News
10/03/2025
Maria Mantas
Personalized high-definition transcranial direct current stimulation (HD-tDCS) induced a significantly greater improvement in mood in patients with depression compared to those who underwent sham treatment.
Personalized high-definition transcranial direct current stimulation (HD-tDCS) induced a significantly greater improvement in mood in patients with depression compared to those who underwent sham treatment.
Personalized high-definition...
10/03/2025
Psych Congress Network
child embraces mother
News
09/02/2025
Maria Mantas
Child depression at ages 10 and 11 years during the COVID-19 pandemic was significantly associated with later maternal depression, according to longitudinal study results.
Child depression at ages 10 and 11 years during the COVID-19 pandemic was significantly associated with later maternal depression, according to longitudinal study results.
Child depression at ages 10 and...
09/02/2025
Psych Congress Network
Three illustrated faces, one sad, one neutral, one happy, with a human hand picking up the happy face
News
05/04/2026
Brionna Mendoza
A randomized clinical trial published in JAMA Psychiatry found that oral semaglutide may improve effort-based decision-making in adults with major depressive disorder (MDD).
A randomized clinical trial published in JAMA Psychiatry found that oral semaglutide may improve effort-based decision-making in adults with major depressive disorder (MDD).
A randomized clinical trial...
05/04/2026
Psych Congress Network
A patient receives psychedelic-assisted therapy
News
04/29/2026
Brionna Mendoza
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed...
04/29/2026
Psych Congress Network
a female soldier stands in front of a row of American flags
News
04/22/2026
Maria Mantas
Active navigated transcranial magnetic stimulation (TMS) added to intensive residential treatment was associated with greater reduction of symptoms in patients with combat-related posttraumatic stress disorder (PTSD) than sham TMS.
Active navigated transcranial magnetic stimulation (TMS) added to intensive residential treatment was associated with greater reduction of symptoms in patients with combat-related posttraumatic stress disorder (PTSD) than sham TMS.
Active navigated transcranial...
04/22/2026
Psych Congress Network
A doctor sits at a table holding a pill bottle in one hand while filling out paperwork
News
04/14/2026
Brionna Mendoza
A systematic review published in Frontiers in Psychiatry reports that algorithm-guided treatment (AGT) is generally associated with improved remission rates and more timely treatment modifications compared with treatment as usual (TAU).
A systematic review published in Frontiers in Psychiatry reports that algorithm-guided treatment (AGT) is generally associated with improved remission rates and more timely treatment modifications compared with treatment as usual (TAU).
A systematic review published in...
04/14/2026
Psych Congress Network
a person attempts to pick up a glass of water
News
04/14/2026
Maria Mantas
Neurocrine Biosciences reported new real-world evidence demonstrating higher treatment persistence with valbenazine (Ingrezza) compared with deutetrabenazine (Austedo XR) among adults with tardive dyskinesia (TD).
Neurocrine Biosciences reported new real-world evidence demonstrating higher treatment persistence with valbenazine (Ingrezza) compared with deutetrabenazine (Austedo XR) among adults with tardive dyskinesia (TD).
Neurocrine Biosciences reported...
04/14/2026
Psych Congress Network
A boy's hand holding a pill that says ADHD
News
04/13/2026
A phase 3 open-label extension trial found viloxazine ER to be safe and effective for the long-term treatment of pediatric ADHD.
A phase 3 open-label extension trial found viloxazine ER to be safe and effective for the long-term treatment of pediatric ADHD.
A phase 3 open-label extension...
04/13/2026
Psych Congress Network
A teddy bear against a blue background wearing a mask and stethoscope.
News
04/10/2026
Brionna Mendoza
Attention-deficit/hyperactivity disorder (ADHD) diagnosis rates in people younger than 30 years in British Columbia, Canada, rose steadily from 2003 to 2023 and appeared to accelerate after both DSM-5 implementation and the COVID-19 pandemic.
Attention-deficit/hyperactivity disorder (ADHD) diagnosis rates in people younger than 30 years in British Columbia, Canada, rose steadily from 2003 to 2023 and appeared to accelerate after both DSM-5 implementation and the COVID-19 pandemic.
Attention-deficit/hyperactivity...
04/10/2026
Psych Congress Network
A profile of a person split in half, one half teal and the other purple, with a swirl line over the head
News
04/07/2026
Brionna Mendoza
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is...
04/07/2026
Psych Congress Network
a man with depression looks out a window major depressive disorder
Research Summary
04/01/2026
Brionna Mendoza
A Phase 2b randomized clinical trial found nonsignificant differences in response rate between psilocybin 25 mg, psilocybin 5 mg, and placebo with supporting psychotherapy in treatment-resistant major depressive disorder (MDD).
A Phase 2b randomized clinical trial found nonsignificant differences in response rate between psilocybin 25 mg, psilocybin 5 mg, and placebo with supporting psychotherapy in treatment-resistant major depressive disorder (MDD).
A Phase 2b randomized clinical...
04/01/2026
Psych Congress Network
spilled bottle of white pills
News
04/01/2026
Maria Mantas
Interim results from a phase 2 randomized, double-blind, placebo-controlled trial of tazbentetol demonstrated early signals of efficacy across schizophrenia symptom domains.
Interim results from a phase 2 randomized, double-blind, placebo-controlled trial of tazbentetol demonstrated early signals of efficacy across schizophrenia symptom domains.
Interim results from a phase 2...
04/01/2026
Psych Congress Network

Quizzes

Pop quiz written on a blackboard with white chalk
Quiz
11/19/2025
Brionna Mendoza
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
11/19/2025
Psych Congress Network
sticky note that reads "take the quiz"
Quiz
07/31/2025
Maria Mantas
Do you remember what the medication's guideline suggests?
Do you remember what the medication's guideline suggests?
Do you remember what the...
07/31/2025
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
07/14/2025
Maria Mantas
Do you remember the clinical guideline recommendations?
Do you remember the clinical guideline recommendations?
Do you remember the clinical...
07/14/2025
Psych Congress Network
sticky note that reads "take the quiz"
Quiz
05/23/2025
Maria Mantas
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
05/23/2025
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
12/23/2024
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
12/23/2024
Psych Congress Network
Are men or women more affected by depressive episodes?
Quiz
12/17/2024
Pop quiz!
Pop quiz!
Pop quiz!
12/17/2024
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
03/04/2024
Test your clinical knowledge with this quick quiz!
Test your clinical knowledge with this quick quiz!
Test your clinical knowledge...
03/04/2024
Psych Congress Network
Three illustrated faces, one sad, one neutral, one happy.
Quiz
01/08/2024
Test your psychiatry knowledge with this quiz!
Test your psychiatry knowledge with this quiz!
Test your psychiatry knowledge...
01/08/2024
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
11/20/2023
Can you ace this psychiatry quiz?
Can you ace this psychiatry quiz?
Can you ace this psychiatry quiz?
11/20/2023
Psych Congress Network
Pencils spell out quiz.
Quiz
09/25/2023
Test your psychiatry knowledge with this quick quiz!
Test your psychiatry knowledge with this quick quiz!
Test your psychiatry knowledge...
09/25/2023
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
04/30/2026
Maria Mantas
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between...
04/30/2026
Psych Congress Network
an illustrated laptop screen displaying a quiz
Quiz
04/27/2026
Maria Mantas
Can you recall how the use of pharmacogenomic testing impacted treatment outcomes in major depressive disorder (MDD)?
Can you recall how the use of pharmacogenomic testing impacted treatment outcomes in major depressive disorder (MDD)?
Can you recall how the use of...
04/27/2026
Psych Congress Network
a girl playing a game on a tablet while lying on her stomach
Quiz
04/23/2026
How familiar are you with DTx for the treatment of attention-deficit/hyperactivity disorder? Test your knowledge with this short, multiple-choice quiz.
How familiar are you with DTx for the treatment of attention-deficit/hyperactivity disorder? Test your knowledge with this short, multiple-choice quiz.
How familiar are you with DTx...
04/23/2026
Psych Congress Network
A boy's hand holding a pill that says ADHD
Quiz
04/23/2026
Ready to apply the data? Test your knowledge of viloxazine ER for the long-term treatment of pediatric ADHD.
Ready to apply the data? Test your knowledge of viloxazine ER for the long-term treatment of pediatric ADHD.
Ready to apply the data? Test...
04/23/2026
Psych Congress Network
Brooke Kempf, PMHNP-BC, and Jonathan Meyer, MD
Quiz
04/17/2026
Maria Mantas
Do you remember why anticholinergic agents aren't appropriate treatment options for tardive dyskinesia? Test your knowledge with this quiz!
Do you remember why anticholinergic agents aren't appropriate treatment options for tardive dyskinesia? Test your knowledge with this quiz!
Do you remember why...
04/17/2026
Psych Congress Network
Brooke Kempf, PMHNP-BC, and Jonathan Meyer, MD
Quiz
04/17/2026
Maria Mantas
Do you remember why anticholinergic agents aren't appropriate treatment options for tardive dyskinesia? Test your knowledge with this quiz!
Do you remember why anticholinergic agents aren't appropriate treatment options for tardive dyskinesia? Test your knowledge with this quiz!
Do you remember why...
04/17/2026
Psych Congress Network
Edward Kaftarian, MD
Quiz
03/23/2026
Maria Mantas
Test your knowledge with this faculty insights quiz!
Test your knowledge with this faculty insights quiz!
Test your knowledge with this...
03/23/2026
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
02/26/2026
Maria Mantas
Do you remember what the APA guideline recommends? Test your knowledge with this quiz!
Do you remember what the APA guideline recommends? Test your knowledge with this quiz!
Do you remember what the APA...
02/26/2026
Psych Congress Network
blocks spelling out the word "quiz"
Quiz
02/12/2026
Maria Mantas
Do you remember what the research says? Test your knowledge with this quick quiz!
Do you remember what the research says? Test your knowledge with this quick quiz!
Do you remember what the...
02/12/2026
Psych Congress Network
An illustration of a pencil marking answers on a quiz sheet.
Quiz
02/04/2026
Brionna Mendoza
Test your prescribing and administration knowledge with this quiz!
Test your prescribing and administration knowledge with this quiz!
Test your prescribing and...
02/04/2026
Psych Congress Network