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Bipolar Disorders Topic Center

Food and Drug Administration building
News
FDA Approves Milsaperidone for Bipolar I and Schizophrenia in Adults
02/24/2026
Maria Mantas
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved...
02/24/2026
Psych Congress Network
Two pill bottles tipped over with pills on a table
News
Adolescent SSRI Use Not Causally Linked to Bipolar Disorder Risk, UK Registry Study Finds
01/06/2026
Sarah Fleming
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ...
01/06/2026
Psych Congress Network
artificial intelligence
News
AI-Based Prediction Tool Flags Psychotic and Bipolar Disorder Risk
01/05/2026
Maria Mantas
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an...
01/05/2026
Psych Congress Network
Postpartum mother holding child
News
Postpartum Psychosis Should Be a Distinct Diagnosis, Experts Recommend
11/19/2025
Maria Mantas
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is...
11/19/2025
Psych Congress Network
Covid-19
News
COVID-19 Post-Acute Sequelae More Likely in Patients With Serious Mental Illness
11/03/2025
Jolynn Tumolo
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia,...
11/03/2025
Psych Congress Network
US FDA sign
News
FDA OKs Once Monthly Subcutaneous Risperidone for Bipolar I Disorder
10/20/2025
Brionna Mendoza
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug...
10/20/2025
Psych Congress Network
stethoscope, pills, and a brain
News
Stimulant Treatment for ADHD Associated With Psychosis and BD
09/25/2025
Maria Mantas
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment...
09/25/2025
Psych Congress Network
DNA puzzle
News
Recent Cohort Study Assesses Genetic Relationships Between Psychotic Disorders
07/23/2025
Maria Mantas
From a genetic perspective, delusional disorder, acute psychoses, psychosis otherwise not specified, and schizoaffective disorder do not appear to be subtypes of schizophrenia, bipolar disorder, or major depression.
From a genetic perspective, delusional disorder, acute psychoses, psychosis otherwise not specified, and schizoaffective disorder do not appear to be subtypes of schizophrenia, bipolar disorder, or major depression.
From a genetic perspective,...
07/23/2025
Psych Congress Network
Conference presenter
News
Olanzapine/Samidorphan Demonstrates Favorable Safety Profile in 4-Year Open-Label Study
11/01/2024
Brionna Mendoza
Combination olanzapine/samidorphan (OLZ/SAM) maintained consistent symptom control in patients with schizophrenia or bipolar I disorder and demonstrated a favorable long-term safety profile over 4 years consistent with previous studies.
Combination olanzapine/samidorphan (OLZ/SAM) maintained consistent symptom control in patients with schizophrenia or bipolar I disorder and demonstrated a favorable long-term safety profile over 4 years consistent with previous studies.
Combination...
11/01/2024
Psych Congress Network
Delusion Themes Stay Consistent Across Psychosis Episodes
News
Delusion Themes Stay Consistent Across Psychosis Episodes, Study Finds
08/20/2024
Jolynn Tumolo
Delusion content was similar across episodes of psychosis in patients who relapsed over a 2-year naturalistic course of care, according to a study published in JAMA Psychiatry. 
Delusion content was similar across episodes of psychosis in patients who relapsed over a 2-year naturalistic course of care, according to a study published in JAMA Psychiatry. 
Delusion content was similar...
08/20/2024
Psych Congress Network
fda
News
FDA Approves Iloperidone for Acute Treatment of Bipolar I Disorder
04/08/2024
Meagan Thistle
Ilperidone, already approved for acute schizophrenia treatment, received FDA approval on Friday for acute treatment of manic or mixed episodes associated with bipolar I in adults.
Ilperidone, already approved for acute schizophrenia treatment, received FDA approval on Friday for acute treatment of manic or mixed episodes associated with bipolar I in adults.
Ilperidone, already approved for...
04/08/2024
Psych Congress Network

News

Food and Drug Administration building
News
FDA Approves Milsaperidone for Bipolar I and Schizophrenia in Adults
02/24/2026
Maria Mantas
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved...
02/24/2026
Psych Congress Network
Two pill bottles tipped over with pills on a table
News
Adolescent SSRI Use Not Causally Linked to Bipolar Disorder Risk, UK Registry Study Finds
01/06/2026
Sarah Fleming
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ...
01/06/2026
Psych Congress Network
artificial intelligence
News
AI-Based Prediction Tool Flags Psychotic and Bipolar Disorder Risk
01/05/2026
Maria Mantas
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an...
01/05/2026
Psych Congress Network
Postpartum mother holding child
News
Postpartum Psychosis Should Be a Distinct Diagnosis, Experts Recommend
11/19/2025
Maria Mantas
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is...
11/19/2025
Psych Congress Network
Covid-19
News
COVID-19 Post-Acute Sequelae More Likely in Patients With Serious Mental Illness
11/03/2025
Jolynn Tumolo
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia,...
11/03/2025
Psych Congress Network
US FDA sign
News
FDA OKs Once Monthly Subcutaneous Risperidone for Bipolar I Disorder
10/20/2025
Brionna Mendoza
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug...
10/20/2025
Psych Congress Network
stethoscope, pills, and a brain
News
Stimulant Treatment for ADHD Associated With Psychosis and BD
09/25/2025
Maria Mantas
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment...
09/25/2025
Psych Congress Network
DNA puzzle
News
Recent Cohort Study Assesses Genetic Relationships Between Psychotic Disorders
07/23/2025
Maria Mantas
From a genetic perspective, delusional disorder, acute psychoses, psychosis otherwise not specified, and schizoaffective disorder do not appear to be subtypes of schizophrenia, bipolar disorder, or major depression.
From a genetic perspective, delusional disorder, acute psychoses, psychosis otherwise not specified, and schizoaffective disorder do not appear to be subtypes of schizophrenia, bipolar disorder, or major depression.
From a genetic perspective,...
07/23/2025
Psych Congress Network
Conference presenter
News
Olanzapine/Samidorphan Demonstrates Favorable Safety Profile in 4-Year Open-Label Study
11/01/2024
Brionna Mendoza
Combination olanzapine/samidorphan (OLZ/SAM) maintained consistent symptom control in patients with schizophrenia or bipolar I disorder and demonstrated a favorable long-term safety profile over 4 years consistent with previous studies.
Combination olanzapine/samidorphan (OLZ/SAM) maintained consistent symptom control in patients with schizophrenia or bipolar I disorder and demonstrated a favorable long-term safety profile over 4 years consistent with previous studies.
Combination...
11/01/2024
Psych Congress Network
Delusion Themes Stay Consistent Across Psychosis Episodes
News
Delusion Themes Stay Consistent Across Psychosis Episodes, Study Finds
08/20/2024
Jolynn Tumolo
Delusion content was similar across episodes of psychosis in patients who relapsed over a 2-year naturalistic course of care, according to a study published in JAMA Psychiatry. 
Delusion content was similar across episodes of psychosis in patients who relapsed over a 2-year naturalistic course of care, according to a study published in JAMA Psychiatry. 
Delusion content was similar...
08/20/2024
Psych Congress Network
spilled bottle of white pills
News
Clozapine Shows Superior Response After First Antipsychotic Failure
03/20/2026
Maria Mantas
Clozapine was more effective than olanzapine and amisulpride in first-episode psychosis (FEP) patients with schizophrenia, schizophreniform, or schizoaffective disorder who did not respond to an initial antipsychotic, according to recent...
Clozapine was more effective than olanzapine and amisulpride in first-episode psychosis (FEP) patients with schizophrenia, schizophreniform, or schizoaffective disorder who did not respond to an initial antipsychotic, according to recent...
Clozapine was more effective...
03/20/2026
Psych Congress Network
a person holds a glass of water and pills
News
Antidepressant Use Patterns May Help Personalize MDD Treatment
03/16/2026
Brionna Mendoza
A new cohort study published in JAMA Psychiatry examined whether real-world antidepressant prescription patterns in MDD patients could help identify biologically meaningful subtypes of depression.
A new cohort study published in JAMA Psychiatry examined whether real-world antidepressant prescription patterns in MDD patients could help identify biologically meaningful subtypes of depression.
A new cohort study published in...
03/16/2026
Psych Congress Network
a man running on a beach
News
Review Urges Greater Exercise Integration in Schizophrenia, SMI Care
03/16/2026
Brionna Mendoza
The integration of physical activity into routine psychiatric care could significantly improve outcomes for people with severe mental illness (SMI), including schizophrenia, according to a narrative review published in JAMA Psychiatry.
The integration of physical activity into routine psychiatric care could significantly improve outcomes for people with severe mental illness (SMI), including schizophrenia, according to a narrative review published in JAMA Psychiatry.
The integration of physical...
03/16/2026
Psych Congress Network
a man sits alone by a lake
News
Loneliness Partially Mediates Link Between Anxiety, Depression, and Suicidal Ideation
03/12/2026
Maria Mantas
Loneliness significantly contributes to the relationship between anxiety symptoms, depressive symptoms, and suicidal ideation among US adults, according to recent analysis findings.
Loneliness significantly contributes to the relationship between anxiety symptoms, depressive symptoms, and suicidal ideation among US adults, according to recent analysis findings.
Loneliness significantly...
03/12/2026
Psych Congress Network
A woman lies on the couch holding an ice pack to her head
News
Migraine Nearly Doubles Depression and Anxiety Risk in Cohort Study
03/10/2026
Brionna Mendoza
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2...
03/10/2026
Psych Congress Network
orange pill bottle antidepressant depression major depressive disorder MDD
News
Decision Tool Reduces Antidepressant Dropout in Major Depressive Disorder
03/06/2026
Brionna Mendoza
A clinical decision-support system called PETRUSHKA was found to improve antidepressant continuation in adults with major depressive disorder (MDD). The tool also improved depression and anxiety symptoms.
A clinical decision-support system called PETRUSHKA was found to improve antidepressant continuation in adults with major depressive disorder (MDD). The tool also improved depression and anxiety symptoms.
A clinical decision-support...
03/06/2026
Psych Congress Network
a strand of DNA
News
Copy Number Variant Deletions Linked to Earlier Schizophrenia Onset
03/05/2026
Maria Mantas
Increased copy number variant (CNV) burden, specifically deletions, is associated with earlier age at onset (AAO) of schizophrenia, according to recent research findings.
Increased copy number variant (CNV) burden, specifically deletions, is associated with earlier age at onset (AAO) of schizophrenia, according to recent research findings.
Increased copy number variant...
03/05/2026
Psych Congress Network
an illustration of a man sitting on the ground holding his head with his profile and brain in the background
News
Indirect Costs Drive $366B Schizophrenia Burden in US
02/27/2026
Brionna Mendoza
A comprehensive economic evaluation reported substantial national and state-level societal costs of schizophrenia in the United States for the 2024 calendar year, estimating a total excess societal cost at $366.8 billion.
A comprehensive economic evaluation reported substantial national and state-level societal costs of schizophrenia in the United States for the 2024 calendar year, estimating a total excess societal cost at $366.8 billion.
A comprehensive economic...
02/27/2026
Psych Congress Network
Food and Drug Administration building
News
FDA Approves Milsaperidone for Bipolar I and Schizophrenia in Adults
02/24/2026
Maria Mantas
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved...
02/24/2026
Psych Congress Network
psilocybin-containing mushrooms in a beaker
News
Synthetic Psilocybin Meets Primary Endpoint in Phase 3 Treatment-Resistant Depression Trial
02/19/2026
Maria Mantas
A synthetic form of psilocybin (COMP360) has met the primary endpoint in a second phase 3 trial evaluating its efficacy and safety in patients with treatment-resistant depression (TRD).
A synthetic form of psilocybin (COMP360) has met the primary endpoint in a second phase 3 trial evaluating its efficacy and safety in patients with treatment-resistant depression (TRD).
A synthetic form of psilocybin...
02/19/2026
Psych Congress Network

Quizzes

Death risk increased by how much with a bipolar disorder diagnosis?
Quiz
Death risk increased by how much with a bipolar disorder diagnosis?
02/26/2024
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
02/26/2024
Psych Congress Network
polygenic risk scores
Quiz
Is there an association between hospitalization frequency and polygenic risk score?
10/06/2022
Take the quiz to test your clinical knowledge!
Take the quiz to test your clinical knowledge!
Take the quiz to test your...
10/06/2022
Psych Congress Network
COVID-19 risk.
Quiz
Antipsychotic Use and COVID-19 Risk in Patients with BD and SMI
06/15/2022
How does antipsychotic use affect COVID-19 risk? Take the quiz now to test your knowledge!
How does antipsychotic use affect COVID-19 risk? Take the quiz now to test your knowledge!
How does antipsychotic use...
06/15/2022
Psych Congress Network
Quiz
Challenges for Patients With Bipolar Disorder
01/11/2022
According to a recent survey, which of the following concerns did patients with bipolar-I disorder report?
According to a recent survey, which of the following concerns did patients with bipolar-I disorder report?
According to a recent survey,...
01/11/2022
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
Pharmacologic Intervention in Bulimia Nervosa
02/26/2026
Maria Mantas
Do you remember what the APA guideline recommends? Test your knowledge with this quiz!
Do you remember what the APA guideline recommends? Test your knowledge with this quiz!
Do you remember what the APA...
02/26/2026
Psych Congress Network
blocks spelling out the word "quiz"
Quiz
Screen Time, Brain Structure, and ADHD in Children
02/12/2026
Maria Mantas
Do you remember what the research says? Test your knowledge with this quick quiz!
Do you remember what the research says? Test your knowledge with this quick quiz!
Do you remember what the...
02/12/2026
Psych Congress Network
An illustration of a pencil marking answers on a quiz sheet.
Quiz
Intranasal Esketamine Dosage for Adult MDD
02/04/2026
Brionna Mendoza
Test your prescribing and administration knowledge with this quiz!
Test your prescribing and administration knowledge with this quiz!
Test your prescribing and...
02/04/2026
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
Brain Aging in Schizophrenia
01/22/2026
Maria Mantas
Test your knowledge of recent research with this quick quiz!
Test your knowledge of recent research with this quick quiz!
Test your knowledge of recent...
01/22/2026
Psych Congress Network
An illustration of a pencil marking answers on a quiz sheet
Guidelines Quiz
Medication Monitoring in Patients With BPD
01/20/2026
Brionna Mendoza
Test your knowledge of APA guidelines with this quiz!
Test your knowledge of APA guidelines with this quiz!
Test your knowledge of APA...
01/20/2026
Psych Congress Network
Mark Olfson, MD, MPH
Quiz
Telemental Health Use Patterns
01/16/2026
Maria Mantas
Are you caught up with the latest research on telehealth use patterns?
Are you caught up with the latest research on telehealth use patterns?
Are you caught up with the...
01/16/2026
Psych Congress Network
illustration of a laptop screen displaying a test
Quiz
Stimulants and Psychosis Risk in ADHD
12/22/2025
Maria Mantas
Do you remember the findings from this systematic review?
Do you remember the findings from this systematic review?
Do you remember the findings...
12/22/2025
Psych Congress Network
Joseph Goldberg, MD
Quiz
Diagnosing Mixed Features in Bipolar Disorder
12/03/2025
Joseph F. Goldberg, MD
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
12/03/2025
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
Depression, Inflammation, and Insomnia
11/19/2025
Brionna Mendoza
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
11/19/2025
Psych Congress Network
quiz
Quiz
Early Lead Exposure and Mental Health Outcomes
11/10/2025
Maria Mantas
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
11/10/2025
Psych Congress Network

NEW FROM THE NP INSTITUTE ONLINE LEARNING HUB

andrew and julie
Rapid Refresh
Navigating Bipolar Disorder Treatment: Exploring the Role of Second-Generation Antipsychotics
04/11/2024

Featuring Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN

Featuring Andrew Penn, MS, PMHNP...
Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN, explore the nuanced role of second-generation antipsychotics in bipolar disorder treatment. They discuss the complexities of managing mania and depression phases and...
Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN, explore the nuanced role of second-generation antipsychotics in bipolar disorder treatment. They discuss the complexities of managing mania and depression phases and...
Andrew Penn, MS, PMHNP, and...
04/11/2024
Psych Congress NP Institute
Amber Hoberg
Rapid Refresh
Long-Acting Injectables for Adolescents With Schizophrenia and Schizoaffective Disorder
04/10/2024
Amber Hoberg, MSN, APRN, PMHNP-BC
Amber Hoberg, PMHNP-BC, navigates the complexities of adolescent psychosis treatment, exploring the potential benefits and considerations of LAIs for schizophrenia and schizoaffective disorder, while emphasizing evidence-based practice for...
Amber Hoberg, PMHNP-BC, navigates the complexities of adolescent psychosis treatment, exploring the potential benefits and considerations of LAIs for schizophrenia and schizoaffective disorder, while emphasizing evidence-based practice for...
Amber Hoberg, PMHNP-BC,...
04/10/2024
Psych Congress NP Institute
Hoberg and Matthews
Clinical Pearls
Tolerability Testing in Long-Acting Injectable Prescriptions
04/03/2024
Do clinicians need to test for tolerability before prescribing a long-acting injectable (LAI)? Desiree Matthews, PMHNP-BC, and Amber Hoberg, MSN, APRN, PMHNP-BC, offer their clinical insight.
Do clinicians need to test for tolerability before prescribing a long-acting injectable (LAI)? Desiree Matthews, PMHNP-BC, and Amber Hoberg, MSN, APRN, PMHNP-BC, offer their clinical insight.
Do clinicians need to test for...
04/03/2024
Psych Congress NP Institute

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