Abstracts
3427230
(#63) Safety and Effectiveness of Bupropion for Smoking Cessation During Pregnancy: A Scoping Review
Abstract: Objective: The objective of this scoping review is to understand the safety and effectiveness of Bupropion as a smoking cessation aid during pregnancy.
Introduction: Smoking during pregnancy is associated with significant adverse maternal and fetal outcomes. Many pregnant women who continue smoking beyond their first prenatal visit do so throughout their pregnancy. Pharmacologic interventions such as bupropion may be considered when counseling or NRT is insufficient.
Inclusion criteria: This review will include studies involving pregnant individuals at any gestational age who used nicotine products and were treated with bupropion for smoking cessation, regardless of nicotine product type, dosage, or frequency of use. Studies conducted in any setting with no restrictions on age, parity, comorbid conditions, race/ethnicity, or location.
Methods: This scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) methodology and reported following PRISMA-ScR guidelines. A comprehensive search of MEDLINE (PubMed), Embase, Scopus, Cochrane Library, PsycINFO, and clinical trial registries was performed. A Two tiered screening process was utilized with two independent blinded screeners and a third screener as a tiebreaker.
Results: After the initial search, 600 articles underwent deduplication, and two rounds of screening resulting in 14 included articles. 5 of the included articles were randomized controlled trials, 4 were retrospective cohorts, 4 were prospective cohorts/observational studies, and one was a case study. Overall themes of studies included mixed results of the efficacy of bupropion for smoking cessation, but safety data showed bupropion to not be associated with an increase in maternal or fetal negative outcomes.
Short Description: Scoping review that explores the use of bupropion as a treatment for smoking cessation during pregnancy. It summarizes current evidence on both effectiveness and safety across a range of study designs. Provides an overview of the existing literature and guidance for future research.
Name of Sponsoring Organization(s):
Introduction: Smoking during pregnancy is associated with significant adverse maternal and fetal outcomes. Many pregnant women who continue smoking beyond their first prenatal visit do so throughout their pregnancy. Pharmacologic interventions such as bupropion may be considered when counseling or NRT is insufficient.
Inclusion criteria: This review will include studies involving pregnant individuals at any gestational age who used nicotine products and were treated with bupropion for smoking cessation, regardless of nicotine product type, dosage, or frequency of use. Studies conducted in any setting with no restrictions on age, parity, comorbid conditions, race/ethnicity, or location.
Methods: This scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) methodology and reported following PRISMA-ScR guidelines. A comprehensive search of MEDLINE (PubMed), Embase, Scopus, Cochrane Library, PsycINFO, and clinical trial registries was performed. A Two tiered screening process was utilized with two independent blinded screeners and a third screener as a tiebreaker.
Results: After the initial search, 600 articles underwent deduplication, and two rounds of screening resulting in 14 included articles. 5 of the included articles were randomized controlled trials, 4 were retrospective cohorts, 4 were prospective cohorts/observational studies, and one was a case study. Overall themes of studies included mixed results of the efficacy of bupropion for smoking cessation, but safety data showed bupropion to not be associated with an increase in maternal or fetal negative outcomes.
Short Description: Scoping review that explores the use of bupropion as a treatment for smoking cessation during pregnancy. It summarizes current evidence on both effectiveness and safety across a range of study designs. Provides an overview of the existing literature and guidance for future research.
Name of Sponsoring Organization(s):
