Abstracts
3427180
(#22) Non-Clinical Risk Factors for Depression in Aphasia: Insights from the All of Us Dataset
Abstract: Background: Aphasia, a language disorder most commonly caused by neurological injury, significantly impairs daily functioning and quality of life. Depression affects over 50[AA1.1]% of persons with aphasia (PWA) within the first year, driven by communication barriers, reduced independence, and social isolation. Although clinical contributors to post-aphasia depression are well documented, the role of demographic and social determinants of health (SDOH) remains underexplored in large, diverse cohorts. This study examined demographic and SDOH predictors of depression among PWA in the All of Us Research Program.
Methods: As part of a larger study identifying depression risk factors among PWA, a cross-sectional analysis of 1,815 participants with a documented history of aphasia was conducted. Participants were categorized based on the presence or absence of a documented depression diagnosis[AA2.1]. Multivariable logistic regression estimated odds ratios (ORs) for depression, adjusting for age, biological sex, race, marital status, employment, income, and education.
Results: Among 1,815 participants with aphasia, 153 (8.4%) had a documented depression diagnosis. Younger age and unemployment were significant independent predictors of depression. Each additional year of age was associated with lower odds of depression (OR 0.977, 95% CI 0.961-0.992, p=0.004). Participants not employed for wages had 1.71 times higher odds of depression compared to those employed (OR 1.709, 95% CI 1.015-2.876, p=0.044). Other demographic variables were not statistically significant after adjustment.
Conclusions: Post-aphasia depression disproportionately affects younger individuals and those experiencing unemployment. Targeted mental health screening for younger patients and integration of vocational support into post-aphasia care may improve outcomes.
Short Description: Aphasia is frequently accompanied by depression, yet non-clinical risk factors remain underexplored. This poster presentation explores nonclinical factors of this co-occurance (e.g., demographic, social drivers of health) in a cross-sectional analysis of 1,815 individuals with aphasia from the All of Us dataset. Findings from this preliminary analysis highlight the importance of targeted mental health screening and vocational support in post-aphasia care.
Name of Sponsoring Organization(s): This study used data from the All of Us Research Program's Registered Tier Dataset v8, available to authorized users on the Researcher Workbench. This research was also, in part, funded by the National Institutes of Health (NIH) Agreement No.1OT2OD032581. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the NIH. We gratefully acknowledge All of Us participants for their contributions, without whom this research would not have been possible. We also thank the National Institutes of Health's All of Us Research Program for making available the participant data [and/or samples and/or cohort] examined in this study.
Methods: As part of a larger study identifying depression risk factors among PWA, a cross-sectional analysis of 1,815 participants with a documented history of aphasia was conducted. Participants were categorized based on the presence or absence of a documented depression diagnosis[AA2.1]. Multivariable logistic regression estimated odds ratios (ORs) for depression, adjusting for age, biological sex, race, marital status, employment, income, and education.
Results: Among 1,815 participants with aphasia, 153 (8.4%) had a documented depression diagnosis. Younger age and unemployment were significant independent predictors of depression. Each additional year of age was associated with lower odds of depression (OR 0.977, 95% CI 0.961-0.992, p=0.004). Participants not employed for wages had 1.71 times higher odds of depression compared to those employed (OR 1.709, 95% CI 1.015-2.876, p=0.044). Other demographic variables were not statistically significant after adjustment.
Conclusions: Post-aphasia depression disproportionately affects younger individuals and those experiencing unemployment. Targeted mental health screening for younger patients and integration of vocational support into post-aphasia care may improve outcomes.
Short Description: Aphasia is frequently accompanied by depression, yet non-clinical risk factors remain underexplored. This poster presentation explores nonclinical factors of this co-occurance (e.g., demographic, social drivers of health) in a cross-sectional analysis of 1,815 individuals with aphasia from the All of Us dataset. Findings from this preliminary analysis highlight the importance of targeted mental health screening and vocational support in post-aphasia care.
Name of Sponsoring Organization(s): This study used data from the All of Us Research Program's Registered Tier Dataset v8, available to authorized users on the Researcher Workbench. This research was also, in part, funded by the National Institutes of Health (NIH) Agreement No.1OT2OD032581. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the NIH. We gratefully acknowledge All of Us participants for their contributions, without whom this research would not have been possible. We also thank the National Institutes of Health's All of Us Research Program for making available the participant data [and/or samples and/or cohort] examined in this study.
