Atopic Dermatitis, Food Allergies Show Commonalities
Findings of a recent study revealed that impaired skin barrier function, systemic sensitization, and Th2-driven inflammation are major factors in both food allergies (FA) and atopic dermatitis (AD) in children.
The investigator conducted targeted analysis and synthesis of published research into diagnostic strategies, immunopathology and clinical guidelines. Selection criteria emphasized thematic relevance to the interplay between AD and FA and innovations in therapy.
“Filaggrin deficiency, lipid abnormalities, and altered skin microbiota contribute to cutaneous and systemic immune dysregulation,” author Sonila Borici, PhD, wrote in Acta Paediatrica. “Children with severe AD show a higher prevalence of food sensitization, suggesting a bidirectional link. Sensitization via damaged skin may promote gastrointestinal allergic responses.”
Dr Borici stated that effective diagnosis requires a thorough medical history, use of laboratory markers, and provocation testing, while treatment should aim to restore skin integrity, modulate immune responses, and manage dietary allergens.
“AD and FA share common pathophysiological pathways that warrant coordinated diagnostic and therapeutic strategies,” she concluded. “Understanding their interrelation is essential for developing individualized prevention and treatment plans, especially in pediatric populations vulnerable to allergic progression.”
Resource:
Borici S. Atopic dermatitis and food allergy in children. Acta Paediatric. 2025;114(12): 3096-3107 https://doi.org/10.1111/apa.70283
