Initial Experience with Flowable Porcine Urinary Bladder Matrix in Podiatric Wounds: A Multi-center Case Series

Introduction: Tunneling and undermining continue to complicate podiatric wound management. Cellular, acellular, and matrix-based prod- ucts (CAMPs) are often utilized as a part of standard of care to achieve wound closure in complex podiatric wounds. The porcine-derived urinary bladder matrix (UBM) particulate and sheets have been associated with a pro-remodeling host immune response that supports complex wound closure. Recently, a flowable preparation of the UBM particulate was cleared for use in same indications, including ulcers and surgical wounds with tunneling and undermining. Methods: This multi-center case series captures the initial experiences of two foot and ankle surgeons utilizing flowable porcine UBM in six patients. Pertinent patient demographics, history, wound size, notes on device handling and application, and available early follow-up outcomes ( >/= 90 days), including time to closure were collected Results: All six patients showed clinical improvement following use of flowable UBM device. Four patients attained wound closure following one or two applications within a 12 weeks’ time span. One patient was lost to follow up and another was eight weeks post device application with clinical evidence of healing. A table of summary will be presented to chronicle individual patient journeys Discussion: This early positive experience with the flowable configu- ration of UBM in complex podiatric wounds should serve as a prelude to further research on its utility in these difficult-to-treat chronic ulcers